R01 EB027793/EB/NIBIB NIH HHS/United States[Grants and Funding] - Search Results

Year	Number of Results
2020	3
2021	4
2022	5
2023	7
2024	4

1

Phage-assisted evolution and protein engineering yield compact, efficient prime editors.

Doman JL, Pandey S, Neugebauer ME, An M, Davis JR, Randolph PB, McElroy A, Gao XD, Raguram A, Richter MF, Everette KA, Banskota S, Tian K, Tao YA, Tolar J, Osborn MJ, Liu DR. Doman JL, et al. Cell. 2023 Aug 31;186(18):3983-4002.e26. doi: 10.1016/j.cell.2023.07.039. Cell. 2023. PMID: 37657419 Free PMC article.

2

Phage-assisted continuous and non-continuous evolution.

Miller SM, Wang T, Liu DR. Miller SM, et al. Nat Protoc. 2020 Dec;15(12):4101-4127. doi: 10.1038/s41596-020-00410-3. Epub 2020 Nov 16. Nat Protoc. 2020. PMID: 33199872 Free PMC article.

3

Phage-assisted evolution of botulinum neurotoxin proteases with reprogrammed specificity.

Blum TR, Liu H, Packer MS, Xiong X, Lee PG, Zhang S, Richter M, Minasov G, Satchell KJF, Dong M, Liu DR. Blum TR, et al. Science. 2021 Feb 19;371(6531):803-810. doi: 10.1126/science.abf5972. Science. 2021. PMID: 33602850 Free PMC article.

4

Proteolysis-targeting chimeras with reduced off-targets.

Nguyen TM, Sreekanth V, Deb A, Kokkonda P, Tiwari PK, Donovan KA, Shoba V, Chaudhary SK, Mercer JAM, Lai S, Sadagopan A, Jan M, Fischer ES, Liu DR, Ebert BL, Choudhary A. Nguyen TM, et al. Nat Chem. 2024 Feb;16(2):218-228. doi: 10.1038/s41557-023-01379-8. Epub 2023 Dec 18. Nat Chem. 2024. PMID: 38110475 Free PMC article.

5

CRISPR-free base editors with enhanced activity and expanded targeting scope in mitochondrial and nuclear DNA.

Mok BY, Kotrys AV, Raguram A, Huang TP, Mootha VK, Liu DR. Mok BY, et al. Nat Biotechnol. 2022 Sep;40(9):1378-1387. doi: 10.1038/s41587-022-01256-8. Epub 2022 Apr 4. Nat Biotechnol. 2022. PMID: 35379961 Free PMC article.

6

Continuous evolution of compact protein degradation tags regulated by selective molecular glues.

Mercer JAM, DeCarlo SJ, Roy Burman SS, Sreekanth V, Nelson AT, Hunkeler M, Chen PJ, Donovan KA, Kokkonda P, Tiwari PK, Shoba VM, Deb A, Choudhary A, Fischer ES, Liu DR. Mercer JAM, et al. Science. 2024 Mar 15;383(6688):eadk4422. doi: 10.1126/science.adk4422. Epub 2024 Mar 15. Science. 2024. PMID: 38484051

7

High-throughput continuous evolution of compact Cas9 variants targeting single-nucleotide-pyrimidine PAMs.

Huang TP, Heins ZJ, Miller SM, Wong BG, Balivada PA, Wang T, Khalil AS, Liu DR. Huang TP, et al. Nat Biotechnol. 2023 Jan;41(1):96-107. doi: 10.1038/s41587-022-01410-2. Epub 2022 Sep 8. Nat Biotechnol. 2023. PMID: 36076084 Free PMC article.

8

Evolution of an adenine base editor into a small, efficient cytosine base editor with low off-target activity.

Neugebauer ME, Hsu A, Arbab M, Krasnow NA, McElroy AN, Pandey S, Doman JL, Huang TP, Raguram A, Banskota S, Newby GA, Tolar J, Osborn MJ, Liu DR. Neugebauer ME, et al. Nat Biotechnol. 2023 May;41(5):673-685. doi: 10.1038/s41587-022-01533-6. Epub 2022 Nov 10. Nat Biotechnol. 2023. PMID: 36357719 Free PMC article.

9

Cooperative assembly confers regulatory specificity and long-term genetic circuit stability.

Bragdon MDJ, Patel N, Chuang J, Levien E, Bashor CJ, Khalil AS. Bragdon MDJ, et al. Cell. 2023 Aug 31;186(18):3810-3825.e18. doi: 10.1016/j.cell.2023.07.012. Epub 2023 Aug 7. Cell. 2023. PMID: 37552983 Free article.

10

Compact zinc finger base editors that edit mitochondrial or nuclear DNA in vitro and in vivo.

Willis JCW, Silva-Pinheiro P, Widdup L, Minczuk M, Liu DR. Willis JCW, et al. Nat Commun. 2022 Nov 23;13(1):7204. doi: 10.1038/s41467-022-34784-7. Nat Commun. 2022. PMID: 36418298 Free PMC article.

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