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Mechanism of the eukaryotic chaperonin: protein folding in the chamber of secrets.
Trends Cell Biol. 2004 Nov;14(11):598-604. doi: 10.1016/j.tcb.2004.09.015.
Trends Cell Biol. 2004.
PMID: 15519848
Free PMC article.
Review.
Dual action of ATP hydrolysis couples lid closure to substrate release into the group II chaperonin chamber.
Douglas NR, Reissmann S, Zhang J, Chen B, Jakana J, Kumar R, Chiu W, Frydman J.
Douglas NR, et al.
Cell. 2011 Jan 21;144(2):240-52. doi: 10.1016/j.cell.2010.12.017.
Cell. 2011.
PMID: 21241893
Free PMC article.
Item in Clipboard
The chaperonin TRiC controls polyglutamine aggregation and toxicity through subunit-specific interactions.
Tam S, Geller R, Spiess C, Frydman J.
Tam S, et al.
Nat Cell Biol. 2006 Oct;8(10):1155-62. doi: 10.1038/ncb1477. Epub 2006 Sep 17.
Nat Cell Biol. 2006.
PMID: 16980959
Free PMC article.
Item in Clipboard
Mechanism of lid closure in the eukaryotic chaperonin TRiC/CCT.
Booth CR, Meyer AS, Cong Y, Topf M, Sali A, Ludtke SJ, Chiu W, Frydman J.
Booth CR, et al.
Nat Struct Mol Biol. 2008 Jul;15(7):746-53. doi: 10.1038/nsmb.1436. Epub 2008 Jun 8.
Nat Struct Mol Biol. 2008.
PMID: 18536725
Free PMC article.
Item in Clipboard
The chaperonin TRiC blocks a huntingtin sequence element that promotes the conformational switch to aggregation.
Tam S, Spiess C, Auyeung W, Joachimiak L, Chen B, Poirier MA, Frydman J.
Tam S, et al.
Nat Struct Mol Biol. 2009 Dec;16(12):1279-85. doi: 10.1038/nsmb.1700. Epub 2009 Nov 15.
Nat Struct Mol Biol. 2009.
PMID: 19915590
Free PMC article.
Item in Clipboard
Identification of the TRiC/CCT substrate binding sites uncovers the function of subunit diversity in eukaryotic chaperonins.
Spiess C, Miller EJ, McClellan AJ, Frydman J.
Spiess C, et al.
Mol Cell. 2006 Oct 6;24(1):25-37. doi: 10.1016/j.molcel.2006.09.003.
Mol Cell. 2006.
PMID: 17018290
Free PMC article.
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Essential function of the built-in lid in the allosteric regulation of eukaryotic and archaeal chaperonins.
Reissmann S, Parnot C, Booth CR, Chiu W, Frydman J.
Reissmann S, et al.
Nat Struct Mol Biol. 2007 May;14(5):432-40. doi: 10.1038/nsmb1236. Epub 2007 Apr 29.
Nat Struct Mol Biol. 2007.
PMID: 17460696
Free PMC article.
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