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Overexpression of Nitric Oxide Synthase Restores Circulating Angiogenic Cell Function in Patients With Coronary Artery Disease: Implications for Autologous Cell Therapy for Myocardial Infarction.
Chen Q, Varga M, Wang X, Haddad DJ, An S, Medzikovic L, Derakhshandeh R, Kostyushev DS, Zhang Y, Clifford BT, Luu E, Danforth OM, Rafikov R, Gong W, Black SM, Suchkov SV, Fineman JR, Heiss C, Aschbacher K, Yeghiazarians Y, Springer ML. Chen Q, et al. J Am Heart Assoc. 2016 Jan 6;5(1):e002257. doi: 10.1161/JAHA.115.002257. J Am Heart Assoc. 2016. PMID: 26738788 Free PMC article.
Nitric oxide synthase expression and functional response to nitric oxide are both important modulators of circulating angiogenic cell response to angiogenic stimuli.
Heiss C, Schanz A, Amabile N, Jahn S, Chen Q, Wong ML, Rassaf T, Heinen Y, Cortese-Krott M, Grossman W, Yeghiazarians Y, Springer ML. Heiss C, et al. Arterioscler Thromb Vasc Biol. 2010 Nov;30(11):2212-8. doi: 10.1161/ATVBAHA.110.211581. Epub 2010 Aug 12. Arterioscler Thromb Vasc Biol. 2010. PMID: 20705916 Free PMC article.
Injection of bone marrow cell extract into infarcted hearts results in functional improvement comparable to intact cell therapy.
Yeghiazarians Y, Zhang Y, Prasad M, Shih H, Saini SA, Takagawa J, Sievers RE, Wong ML, Kapasi NK, Mirsky R, Koskenvuo J, Minasi P, Ye J, Viswanathan MN, Angeli FS, Boyle AJ, Springer ML, Grossman W. Yeghiazarians Y, et al. Mol Ther. 2009 Jul;17(7):1250-6. doi: 10.1038/mt.2009.85. Epub 2009 Apr 21. Mol Ther. 2009. PMID: 19384293 Free PMC article.
Donor myocardial infarction impairs the therapeutic potential of bone marrow cells by an interleukin-1-mediated inflammatory response.
Wang X, Takagawa J, Lam VC, Haddad DJ, Tobler DL, Mok PY, Zhang Y, Clifford BT, Pinnamaneni K, Saini SA, Su R, Bartel MJ, Sievers RE, Carbone L, Kogan S, Yeghiazarians Y, Hermiston M, Springer ML. Wang X, et al. Sci Transl Med. 2011 Sep 14;3(100):100ra90. doi: 10.1126/scitranslmed.3002814. Sci Transl Med. 2011. PMID: 21918107 Free PMC article.
14 results