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2020 2
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2022 3
2023 2
2024 0

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Page 1
Identification and Characterization of a Novel Indoleamine 2,3-Dioxygenase 1 Protein Degrader for Glioblastoma.
Bollu LR, Bommi PV, Monsen PJ, Zhai L, Lauing KL, Bell A, Kim M, Ladomersky E, Yang X, Platanias LC, Matei DE, Bonini MG, Munshi HG, Hashizume R, Wu JD, Zhang B, James CD, Chen P, Kocherginsky M, Horbinski C, Cameron MD, Grigorescu AA, Yamini B, Lukas RV, Schiltz GE, Wainwright DA. Bollu LR, et al. J Med Chem. 2022 Dec 8;65(23):15642-15662. doi: 10.1021/acs.jmedchem.2c00771. Epub 2022 Nov 21. J Med Chem. 2022. PMID: 36410047 Free PMC article.
SLFN11 negatively regulates non-canonical NFkB signaling to promote glioblastoma progression.
Fischietti M, Eckerdt F, Perez RE, Guillen Magaña JN, Mazewski C, Ho S, Gonzalez C, Streich LD, Beauchamp EM, Heimberger AB, Baran AH, Yue F, James CD, Platanias LC. Fischietti M, et al. Cancer Res Commun. 2022 Sep;2(9):966-978. doi: 10.1158/2767-9764.crc-22-0192. Epub 2022 Sep 13. Cancer Res Commun. 2022. PMID: 36382088 Free PMC article.
Combined PI3Kα-mTOR Targeting of Glioma Stem Cells.
Eckerdt FD, Bell JB, Gonzalez C, Oh MS, Perez RE, Mazewski C, Fischietti M, Goldman S, Nakano I, Platanias LC. Eckerdt FD, et al. Sci Rep. 2020 Dec 14;10(1):21873. doi: 10.1038/s41598-020-78788-z. Sci Rep. 2020. PMID: 33318517 Free PMC article.
Tumor Cell IDO Enhances Immune Suppression and Decreases Survival Independent of Tryptophan Metabolism in Glioblastoma.
Zhai L, Bell A, Ladomersky E, Lauing KL, Bollu L, Nguyen B, Genet M, Kim M, Chen P, Mi X, Wu JD, Schipma MJ, Wray B, Griffiths J, Unwin RD, Clark SJ, Acharya R, Bao R, Horbinski C, Lukas RV, Schiltz GE, Wainwright DA. Zhai L, et al. Clin Cancer Res. 2021 Dec 1;27(23):6514-6528. doi: 10.1158/1078-0432.CCR-21-1392. Epub 2021 Sep 3. Clin Cancer Res. 2021. PMID: 34479957 Free PMC article.
Advanced Age Increases Immunosuppression in the Brain and Decreases Immunotherapeutic Efficacy in Subjects with Glioblastoma.
Ladomersky E, Zhai L, Lauing KL, Bell A, Xu J, Kocherginsky M, Zhang B, Wu JD, Podojil JR, Platanias LC, Mochizuki AY, Prins RM, Kumthekar P, Raizer JJ, Dixit K, Lukas RV, Horbinski C, Wei M, Zhou C, Pawelec G, Campisi J, Grohmann U, Prendergast GC, Munn DH, Wainwright DA. Ladomersky E, et al. Clin Cancer Res. 2020 Oct 1;26(19):5232-5245. doi: 10.1158/1078-0432.CCR-19-3874. Epub 2020 Jun 16. Clin Cancer Res. 2020. PMID: 32546647 Free PMC article.