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Enthalpy-Driven Stabilization of Transthyretin by AG10 Mimics a Naturally Occurring Genetic Variant That Protects from Transthyretin Amyloidosis.
Miller M, Pal A, Albusairi W, Joo H, Pappas B, Haque Tuhin MT, Liang D, Jampala R, Liu F, Khan J, Faaij M, Park M, Chan W, Graef I, Zamboni R, Kumar N, Fox J, Sinha U, Alhamadsheh M. Miller M, et al. J Med Chem. 2018 Sep 13;61(17):7862-7876. doi: 10.1021/acs.jmedchem.8b00817. Epub 2018 Aug 22. J Med Chem. 2018. PMID: 30133284 Free PMC article.
A biomimetic approach for enhancing the in vivo half-life of peptides.
Penchala SC, Miller MR, Pal A, Dong J, Madadi NR, Xie J, Joo H, Tsai J, Batoon P, Samoshin V, Franz A, Cox T, Miles J, Chan WK, Park MS, Alhamadsheh MM. Penchala SC, et al. Nat Chem Biol. 2015 Oct;11(10):793-8. doi: 10.1038/nchembio.1907. Epub 2015 Sep 7. Nat Chem Biol. 2015. PMID: 26344696 Free PMC article.