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A novel substituted aminoquinoline selectively targets voltage-sensitive sodium channel isoforms and NMDA receptor subtypes and alleviates chronic inflammatory and neuropathic pain.
Tabakoff B, Ren W, Vanderlinden L, Snell LD, Matheson CJ, Wang ZJ, Levinson R, Smothers CT, Woodward JJ, Honse Y, Lovinger D, Rush AM, Sather WA, Gustafson DL, Hoffman PL. Tabakoff B, et al. Eur J Pharmacol. 2016 Aug 5;784:1-14. doi: 10.1016/j.ejphar.2016.05.006. Epub 2016 May 5. Eur J Pharmacol. 2016. PMID: 27158117 Free PMC article.
AIMing towards improved antitumor efficacy.
Weaver MJ, Kearns AK, Stump S, Li C, Gajewski MP, Rider KC, Backos DS, Reigan PR, Beall HD, Natale NR. Weaver MJ, et al. Bioorg Med Chem Lett. 2015 Apr 15;25(8):1765-1770. doi: 10.1016/j.bmcl.2015.02.063. Epub 2015 Mar 3. Bioorg Med Chem Lett. 2015. PMID: 25782743 Free PMC article.