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GLYX-13, an NMDA receptor glycine site functional partial agonist enhances cognition and produces antidepressant effects without the psychotomimetic side effects of NMDA receptor antagonists.
Moskal JR, Burch R, Burgdorf JS, Kroes RA, Stanton PK, Disterhoft JF, Leander JD. Moskal JR, et al. Expert Opin Investig Drugs. 2014 Feb;23(2):243-54. doi: 10.1517/13543784.2014.852536. Epub 2013 Nov 20. Expert Opin Investig Drugs. 2014. PMID: 24251380 Free PMC article. Review.
Rapastinel (GLYX-13) has therapeutic potential for the treatment of post-traumatic stress disorder: Characterization of a NMDA receptor-mediated metaplasticity process in the medial prefrontal cortex of rats.
Burgdorf J, Kroes RA, Zhang XL, Gross AL, Schmidt M, Weiss C, Disterhoft JF, Burch RM, Stanton PK, Moskal JR. Burgdorf J, et al. Behav Brain Res. 2015 Nov 1;294:177-85. doi: 10.1016/j.bbr.2015.07.039. Epub 2015 Jul 22. Behav Brain Res. 2015. PMID: 26210936 Free PMC article.
Insulin-Like Growth Factor I Produces an Antidepressant-Like Effect and Elicits N-Methyl-D-Aspartate Receptor Independent Long-Term Potentiation of Synaptic Transmission in Medial Prefrontal Cortex and Hippocampus.
Burgdorf J, Zhang XL, Colechio EM, Ghoreishi-Haack N, Gross A, Kroes RA, Stanton PK, Moskal JR. Burgdorf J, et al. Int J Neuropsychopharmacol. 2015 Sep 15;19(2):pyv101. doi: 10.1093/ijnp/pyv101. Int J Neuropsychopharmacol. 2015. PMID: 26374350 Free PMC article.
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