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Developmental etiology for neuroanatomical and cognitive deficits in mice overexpressing Galphas, a G-protein subunit genetically linked to schizophrenia.
Mol Psychiatry. 2009 Apr;14(4):398-415, 347. doi: 10.1038/mp.2008.124. Epub 2008 Nov 25.
Mol Psychiatry. 2009.
PMID: 19030002
Free PMC article.
Constitutive activation of Galphas within forebrain neurons causes deficits in sensorimotor gating because of PKA-dependent decreases in cAMP.
Kelly MP, Isiegas C, Cheung YF, Tokarczyk J, Yang X, Esposito MF, Rapoport DA, Fabian SA, Siegel SJ, Wand G, Houslay MD, Kanes SJ, Abel T.
Kelly MP, et al.
Neuropsychopharmacology. 2007 Mar;32(3):577-88. doi: 10.1038/sj.npp.1301099. Epub 2006 May 31.
Neuropsychopharmacology. 2007.
PMID: 16738544
Free PMC article.
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Chronic Galphas signaling in the striatum increases anxiety-related behaviors independent of developmental effects.
Favilla C, Abel T, Kelly MP.
Favilla C, et al.
J Neurosci. 2008 Dec 17;28(51):13952-6. doi: 10.1523/JNEUROSCI.4986-08.2008.
J Neurosci. 2008.
PMID: 19091983
Free PMC article.
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