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Page 1
Topographic precision in sensory and motor corticostriatal projections varies across cell type and cortical area.
Hooks BM, Papale AE, Paletzki RF, Feroze MW, Eastwood BS, Couey JJ, Winnubst J, Chandrashekar J, Gerfen CR. Hooks BM, et al. Nat Commun. 2018 Sep 3;9(1):3549. doi: 10.1038/s41467-018-05780-7. Nat Commun. 2018. PMID: 30177709 Free PMC article.
The striatum shows general topographic organization and regional differences in behavioral functions. How corticostriatal topography differs across cortical areas and cell types to support these distinct functions is unclear. ...
The striatum shows general topographic organization and regional differences in behavioral functions. How corticostriatal topography …
In vivo human brain expression of histone deacetylases in bipolar disorder.
Tseng CJ, Gilbert TM, Catanese MC, Hightower BG, Peters AT, Parmar AJ, Kim M, Wang C, Roffman JL, Brown HE, Perlis RH, Zürcher NR, Hooker JM. Tseng CJ, et al. Transl Psychiatry. 2020 Jul 8;10(1):224. doi: 10.1038/s41398-020-00911-5. Transl Psychiatry. 2020. PMID: 32641695 Free PMC article.
We assessed uptake in the dorsolateral prefrontal cortex (DLPFC) to compare previous findings of lower uptake in the DLPFC in schizophrenia and found no group differences in BD. Exploratory whole-brain voxelwise analysis showed lower [(11)C]Martinostat uptake in the bilate …
We assessed uptake in the dorsolateral prefrontal cortex (DLPFC) to compare previous findings of lower uptake in the DLPFC in schizophrenia …
Novel polygenic risk score as a translational tool linking depression-related changes in the corticolimbic transcriptome with neural face processing and anhedonic symptoms.
Mareckova K, Hawco C, Dos Santos FC, Bakht A, Calarco N, Miles AE, Voineskos AN, Sibille E, Hariri AR, Nikolova YS. Mareckova K, et al. Transl Psychiatry. 2020 Nov 24;10(1):410. doi: 10.1038/s41398-020-01093-w. Transl Psychiatry. 2020. PMID: 33235204 Free PMC article.
To more directly bridge these lines of work, we generated a novel transcriptome-based polygenic risk score (T-PRS), capturing subtle shifts toward depression-like gene expression patterns in key CLC regions, and mapped this T-PRS onto brain function and related depr …
To more directly bridge these lines of work, we generated a novel transcriptome-based polygenic risk score (T-PRS), capturing subtle shifts …
Correction: JHU-083 selectively blocks glutaminase activity in brain CD11b(+) cells and prevents depression-associated behaviors induced by chronic social defeat stress.
Zhu X, Nedelcovych MT, Thomas AG, Hasegawa Y, Moreno-Megui A, Coomer W, Vohra V, Saito A, Perez G, Wu Y, Alt J, Prchalova E, Tenora L, Majer P, Rais R, Rojas C, Slusher BS, Kamiya A. Zhu X, et al. Neuropsychopharmacology. 2019 May;44(6):1178. doi: 10.1038/s41386-019-0354-3. Epub 2019 Mar 13. Neuropsychopharmacology. 2019. PMID: 30862949 Free PMC article.