Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

Filters

My NCBI Filters

Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1955 1
1968 1
1975 3
1976 1
1977 1
1978 1
1997 1
1998 2
1999 2
2002 1
2004 1
2005 1
2011 1
2013 1
2015 1
2017 1
2018 2
2019 3
2020 3
2021 2
2022 1
2023 3
2024 1

Text availability

Article attribute

Article type

Publication date

Search Results

30 results

Results by year

Filters applied: . Clear all
Page 1
The in vitro metabolism of 11beta-hydroxyprogesterone and 11-ketoprogesterone to 11-ketodihydrotestosterone in the backdoor pathway.
van Rooyen D, Gent R, Barnard L, Swart AC. van Rooyen D, et al. J Steroid Biochem Mol Biol. 2018 Apr;178:203-212. doi: 10.1016/j.jsbmb.2017.12.014. Epub 2017 Dec 23. J Steroid Biochem Mol Biol. 2018. PMID: 29277707
Increased circulating 11beta-hydroxyprogesterone (11OHP4), biosynthesised in the human adrenal, is associated with 21-hydroxylase deficiency in congenital adrenal hyperplasia. 17alpha-hydroxyprogesterone levels are also increased, with the steroid's metabolism to di …
Increased circulating 11beta-hydroxyprogesterone (11OHP4), biosynthesised in the human adrenal, is associated with 21-hydroxyl …
Turning the spotlight on the C11-oxy androgens in human fetal development.
du Toit T, Swart AC. du Toit T, et al. J Steroid Biochem Mol Biol. 2021 Sep;212:105946. doi: 10.1016/j.jsbmb.2021.105946. Epub 2021 Jun 22. J Steroid Biochem Mol Biol. 2021. PMID: 34171490 Review.
Compelling questions are whether the C11-oxy C(19) steroids (11beta-hydroxyandrostenedione, 11beta-hydroxytestosterone, 11-ketoandrostenedione and 11-ketotestosterone [11KT]) and the C11-oxy C(21) steroids (11beta-hydroxyprogesterone and 11-ketoprogesterone) are bio …
Compelling questions are whether the C11-oxy C(19) steroids (11beta-hydroxyandrostenedione, 11beta-hydroxytestosterone, 11-ketoandrostenedio …
11α-Hydroxyprogesterone, a potent 11β-hydroxysteroid dehydrogenase inhibitor, is metabolised by steroid-5α-reductase and cytochrome P450 17α-hydroxylase/17,20-lyase to produce C11α-derivatives of 21-deoxycortisol and 11-hydroxyandrostenedione in vitro.
Gent R, du Toit T, Swart AC. Gent R, et al. J Steroid Biochem Mol Biol. 2019 Jul;191:105369. doi: 10.1016/j.jsbmb.2019.04.018. Epub 2019 Apr 27. J Steroid Biochem Mol Biol. 2019. PMID: 31039398
11alpha-Hydroxyprogesterone (11alphaOHP4) and 11beta-hydroxyprogesterone (11betaOHP4) have been reported to be inhibitors of 11beta-hydroxysteroid dehydrogenase (11betaHSD) type 2, together with 11beta-hydroxytestosterone and 11beta-hydroxyandrostenedione, and their …
11alpha-Hydroxyprogesterone (11alphaOHP4) and 11beta-hydroxyprogesterone (11betaOHP4) have been reported to be inhibitors of 1 …
CYP17A1 exhibits 17alphahydroxylase/17,20-lyase activity towards 11beta-hydroxyprogesterone and 11-ketoprogesterone metabolites in the C11-oxy backdoor pathway.
van Rooyen D, Yadav R, Scott EE, Swart AC. van Rooyen D, et al. J Steroid Biochem Mol Biol. 2020 May;199:105614. doi: 10.1016/j.jsbmb.2020.105614. Epub 2020 Jan 30. J Steroid Biochem Mol Biol. 2020. PMID: 32007561
Increased CYP17A1 activity in endocrine disorders and diseases are associated with elevated C(21) and C(19) steroids which include 17alpha-hydroxyprogesterone and androgens, as well as C11-oxy C(21) and C11-oxy C(19) steroids. We previously reported that 11beta-hydroxyp …
Increased CYP17A1 activity in endocrine disorders and diseases are associated with elevated C(21) and C(19) steroids which include 17alpha-h …
Identification and characterization of functional nongenomic progesterone receptors on human sperm membrane.
Luconi M, Bonaccorsi L, Maggi M, Pecchioli P, Krausz C, Forti G, Baldi E. Luconi M, et al. J Clin Endocrinol Metab. 1998 Mar;83(3):877-85. doi: 10.1210/jcem.83.3.4672. J Clin Endocrinol Metab. 1998. PMID: 9506743 Review.
The high affinity site (Kd in the nanomolar range) appears to be specific for P, whereas the low affinity one (Kd in the micromolar range) binds with equal affinity 11beta-hydroxyprogesterone (11betaOHP) and 17alpha-hydroxyprogesterone (17alphaOHP). ...
The high affinity site (Kd in the nanomolar range) appears to be specific for P, whereas the low affinity one (Kd in the micromolar range) b …
Profiles of 21-Carbon Steroids in 21-hydroxylase Deficiency.
Turcu AF, Rege J, Chomic R, Liu J, Nishimoto HK, Else T, Moraitis AG, Palapattu GS, Rainey WE, Auchus RJ. Turcu AF, et al. J Clin Endocrinol Metab. 2015 Jun;100(6):2283-90. doi: 10.1210/jc.2015-1023. Epub 2015 Apr 7. J Clin Endocrinol Metab. 2015. PMID: 25850025 Free PMC article.

RESULTS: Five C21 steroids were significantly higher in 21OHD patients: 17OHP (67-fold; P < .01), 21-deoxycortisol (21dF; 35-fold; P < .01), 16alpha-hydroxyprogesterone (16OHP; 28-fold; P < .01), progesterone (2-fold; P < .01), and 11beta-hydroxyprogesterone

…

RESULTS: Five C21 steroids were significantly higher in 21OHD patients: 17OHP (67-fold; P < .01), 21-deoxycortisol (21dF; 35-fold; P <

…
Ensuring quality in 17OHP mass spectrometry measurement: an international study assessing isomeric steroid interference.
Ho CS, Hoad K, Cooke BR, Andersen T, Graham P, van den Berg SAA, Hartmann MF, Lo CWS, Loh TP, de Rijke YB, van Zelst BD, Wudy SA, Zakaria R, Greaves RF. Ho CS, et al. Clin Chem Lab Med. 2023 Dec 11;62(5):911-918. doi: 10.1515/cclm-2023-0864. Print 2024 Apr 25. Clin Chem Lab Med. 2023. PMID: 38063179 Free article.
These samples included a control (spiked to 15.0 nmol/L 17OHP) and four challenge samples further enriched with equimolar concentrations of 17OHP isomers (11alpha-hydroxyprogesterone, 11beta-hydroxyprogesterone, 16alpha-hydroxyprogesterone or 21-hydroxyprogesterone) …
These samples included a control (spiked to 15.0 nmol/L 17OHP) and four challenge samples further enriched with equimolar concentrations of …
C11-hydroxy and C11-oxo C19 and C21 Steroids: Pre-Receptor Regulation and Interaction with Androgen and Progesterone Steroid Receptors.
Gent R, Van Rooyen D, Atkin SL, Swart AC. Gent R, et al. Int J Mol Sci. 2023 Dec 20;25(1):101. doi: 10.3390/ijms25010101. Int J Mol Sci. 2023. PMID: 38203272 Free PMC article.
Furthermore, 11-ketodihydrotestosterone (11KDHT), 11-ketotestosterone (11KT) and 11beta-hydroxydihydrotestosterone (11OHDHT) were AR agonists, while only progestogens, 11beta-hydroxyprogesterone (11betaOHP4), 11beta-hydroxydihydroprogesterone (11betaOHDHP4), 11alpha …
Furthermore, 11-ketodihydrotestosterone (11KDHT), 11-ketotestosterone (11KT) and 11beta-hydroxydihydrotestosterone (11OHDHT) were AR agonist …
30 results