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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1961 1
1963 1
1968 1
1975 3
1976 1
1977 2
1978 1
1997 6
1998 5
1999 12
2000 12
2001 10
2002 4
2003 12
2004 11
2005 14
2006 16
2007 10
2008 8
2009 9
2010 6
2011 10
2012 6
2013 7
2014 10
2015 8
2016 6
2017 5
2018 6
2019 5
2020 7
2021 4
2022 6
2023 10
2024 2

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214 results

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Page 1
SOX17 Deficiency Mediates Pulmonary Hypertension: At the Crossroads of Sex, Metabolism, and Genetics.
Sangam S, Sun X, Schwantes-An TH, Yegambaram M, Lu Q, Shi Y, Cook T, Fisher A, Frump AL, Coleman A, Sun Y, Liang S, Crawford H, Lutz KA, Maun AD, Pauciulo MW, Karnes JH, Chaudhary KR, Stewart DJ, Langlais PR, Jain M, Alotaibi M, Lahm T, Jin Y, Gu H, Tang H, Nichols WC, Black SM, Desai AA. Sangam S, et al. Am J Respir Crit Care Med. 2023 Apr 15;207(8):1055-1069. doi: 10.1164/rccm.202203-0450OC. Am J Respir Crit Care Med. 2023. PMID: 36913491 Free PMC article.
Rat lungs in males displayed higher Sox17 expression versus females, suggesting repression by estrogen signaling. Supporting 16alpha-hydroxyestrone (16alphaOHE; a pathologic estrogen metabolite)-mediated repression of SOX17 promoter activity, Sox17(Tg) mice attenuat …
Rat lungs in males displayed higher Sox17 expression versus females, suggesting repression by estrogen signaling. Supporting 16alpha- …
16alpha-Hydroxyestrone: Mass Spectrometry-Based Methodologies for the Identification of Covalent Adducts Formed with Blood Proteins.
Charneira C, Nunes J, Antunes AMM. Charneira C, et al. Chem Res Toxicol. 2020 Aug 17;33(8):2147-2156. doi: 10.1021/acs.chemrestox.0c00171. Epub 2020 Aug 6. Chem Res Toxicol. 2020. PMID: 32692160
Elevated levels of the estrone metabolite, 16alpha-hydroxyestrone (16alphaOHE1), have been linked with multiple diseases. ...
Elevated levels of the estrone metabolite, 16alpha-hydroxyestrone (16alphaOHE1), have been linked with multiple diseases. ...
Estrogen metabolism and autoimmunity.
Cutolo M, Sulli A, Straub RH. Cutolo M, et al. Autoimmun Rev. 2012 May;11(6-7):A460-4. doi: 10.1016/j.autrev.2011.11.014. Epub 2011 Dec 2. Autoimmun Rev. 2012. PMID: 22155198 Review.
It was shown that RA synovial cells mainly produce the cell proproliferative 16alpha-hydroxyestrone which, in addition to 16alpha-hydroxy-17beta-estradiol, is the downstream estrogen metabolite that interferes with monocyte proliferation. ...
It was shown that RA synovial cells mainly produce the cell proproliferative 16alpha-hydroxyestrone which, in addition to 16al …
The Role of Sex in the Pathophysiology of Pulmonary Hypertension.
Docherty CK, Harvey KY, Mair KM, Griffin S, Denver N, MacLean MR. Docherty CK, et al. Adv Exp Med Biol. 2018;1065:511-528. doi: 10.1007/978-3-319-77932-4_31. Adv Exp Med Biol. 2018. PMID: 30051404 Review.
Recent studies have also suggested that estrogen metabolism may be crucial in the development and progression of PAH with studies indicating that downstream metabolites such as 16alpha-hydroxyestrone are upregulated in several forms of experimental pulmonary hyperte …
Recent studies have also suggested that estrogen metabolism may be crucial in the development and progression of PAH with studies indicating …
Epidemiologic studies of estrogen metabolism and breast cancer.
Ziegler RG, Fuhrman BJ, Moore SC, Matthews CE. Ziegler RG, et al. Steroids. 2015 Jul;99(Pt A):67-75. doi: 10.1016/j.steroids.2015.02.015. Epub 2015 Feb 26. Steroids. 2015. PMID: 25725255 Free PMC article. Review.
Early epidemiologic studies of estrogen metabolism measured only 2-hydroxyestrone and 16alpha-hydroxyestrone and relied on direct enzyme immunoassays without purification steps. ...
Early epidemiologic studies of estrogen metabolism measured only 2-hydroxyestrone and 16alpha-hydroxyestrone and relied on dir …
Glucuronidation of estrone and 16alpha-hydroxyestrone by human UGT enzymes: The key roles of UGT1A10 and UGT2B7.
Kallionpää RA, Järvinen E, Finel M. Kallionpää RA, et al. J Steroid Biochem Mol Biol. 2015 Nov;154:104-11. doi: 10.1016/j.jsbmb.2015.07.013. Epub 2015 Jul 26. J Steroid Biochem Mol Biol. 2015. PMID: 26220143
The glucuronidation of estrone and 16alpha-hydroxyestrone by recombinant human UDP-glucuronosyltransferase enzymes (UGTs) of subfamilies 1A, 2A and 2B was studied. ...Human liver microsomes exhibited high rates of 16alpha-hydroxyestrone-16-glucuronide …
The glucuronidation of estrone and 16alpha-hydroxyestrone by recombinant human UDP-glucuronosyltransferase enzymes (UGTs) of s …
Dietary fiber and serum 16alpha-hydroxyestrone, an estrogen metabolite associated with lower systolic blood pressure.
Patel S, Hawkley LC, Cacioppo JT, Masi CM. Patel S, et al. Nutrition. 2011 Jul-Aug;27(7-8):778-81. doi: 10.1016/j.nut.2010.08.017. Epub 2010 Oct 29. Nutrition. 2011. PMID: 21035306 Free PMC article.
Formation of 16alpha-hydroxyestrone is catalyzed primarily by CYP1A2, a cytochrome P450 enzyme. ...Further research is needed regarding dietary factors that may influence the serum concentration of 16alpha-hydroxyestrone....
Formation of 16alpha-hydroxyestrone is catalyzed primarily by CYP1A2, a cytochrome P450 enzyme. ...Further research is needed …
A randomized, double-blind, placebo-controlled, cross-over trial to evaluate the effect of EstroSense() on 2-hydroxyestrone:16alpha-hydroxyestrone ratio in premenopausal women.
Green T, See J, Schauch M, Reil J, Glover M, Brix J, Gerry A, Li K, Newman M, Gahler RJ, Wood S. Green T, et al. J Complement Integr Med. 2022 Oct 6;20(1):199-206. doi: 10.1515/jcim-2022-0301. eCollection 2023 Mar 1. J Complement Integr Med. 2022. PMID: 36201753 Clinical Trial.
This study was conducted to determine if EstroSense use, compared to placebo, promotes a higher urinary 2-hydroxyestrone:16alpha-hydroxyestrone ratio (2-OHE(1):16alpha-OHE(1)), a biomarker associated with a lowered risk of breast cancer. ...
This study was conducted to determine if EstroSense use, compared to placebo, promotes a higher urinary 2-hydroxyestrone:16alpha-h …
Estrogens and autoimmune diseases.
Cutolo M, Capellino S, Sulli A, Serioli B, Secchi ME, Villaggio B, Straub RH. Cutolo M, et al. Ann N Y Acad Sci. 2006 Nov;1089:538-47. doi: 10.1196/annals.1386.043. Ann N Y Acad Sci. 2006. PMID: 17261796 Review.
In the synovial fluids of RA patients, the increased estrogen concentration is observed in both sexes and is more specifically characterized by the hydroxylated forms, in particular 16alpha-hydroxyestrone, which is a mitogenic and cell proliferative endogenous hormo …
In the synovial fluids of RA patients, the increased estrogen concentration is observed in both sexes and is more specifically characterized …
214 results