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Lack of analytical interference of dydrogesterone in progesterone immunoassays.
Eggersmann TK, Wolthuis A, van Amsterdam PH, Griesinger G. Eggersmann TK, et al. Clin Chem Lab Med. 2022 May 11;60(7):1039-1045. doi: 10.1515/cclm-2022-0174. Print 2022 Jun 27. Clin Chem Lab Med. 2022. PMID: 35535412
Herein, we report a systematic in vitro investigation of potential interference of DYD and its active metabolite 20alpha-dihydrodydrogesterone (DHD) in seven widely used, commercially available progesterone assays. ...
Herein, we report a systematic in vitro investigation of potential interference of DYD and its active metabolite 20alpha-dihydrody …
Selectivity and potency of the retroprogesterone dydrogesterone in vitro.
Rižner TL, Brožič P, Doucette C, Turek-Etienne T, Müller-Vieira U, Sonneveld E, van der Burg B, Böcker C, Husen B. Rižner TL, et al. Steroids. 2011 May;76(6):607-15. doi: 10.1016/j.steroids.2011.02.043. Epub 2011 Mar 3. Steroids. 2011. PMID: 21376746
To date, systematic biochemical characterization of this progestin and its active main metabolite, 20alpha-dihydrodydrogesterone, has not been performed in comparison to progesterone. ...Overall, our data show that the anti-androgenic potential of dydrogesterone and …
To date, systematic biochemical characterization of this progestin and its active main metabolite, 20alpha-dihydrodydrogesterone …
Biotechnological production of 20-alpha-dihydrodydrogesterone at pilot scale.
Naumann JM, Zöllner A, Drăgan CA, Messinger J, Adam J, Bureik M. Naumann JM, et al. Appl Biochem Biotechnol. 2011 Sep;165(1):190-203. doi: 10.1007/s12010-011-9243-x. Epub 2011 Apr 15. Appl Biochem Biotechnol. 2011. PMID: 21494755
For progesterone replacement therapy, the synthetic progestogen dydrogesterone is commonly used. In the body, this drug is metabolized to 20alpha-dihydrodydrogesterone (20alpha-DHD), which also shows extensive pharmacological effects and hence could act as a therape …
For progesterone replacement therapy, the synthetic progestogen dydrogesterone is commonly used. In the body, this drug is metabolized to …
Dydrogesterone and 20alpha-dihydrodydrogesterone plasma levels on day of embryo transfer and clinical outcome in an anovulatory programmed frozen-thawed embryo transfer cycle: a prospective cohort study.
Neumann K, Masuch A, Vonthein R, Depenbusch M, Schultze-Mosgau A, Eggersmann TK, Griesinger G. Neumann K, et al. Hum Reprod. 2022 May 30;37(6):1183-1193. doi: 10.1093/humrep/deac045. Hum Reprod. 2022. PMID: 35323905
STUDY QUESTION: What are the plasma concentrations of dydrogesterone (DYD) and its metabolite, 20alpha-dihydrodydrogesterone (DHD), measured on day of embryo transfer (ET) in programmed anovulatory frozen embryo transfer (FET) cycles using 10 mg per os ter-in-die (t …
STUDY QUESTION: What are the plasma concentrations of dydrogesterone (DYD) and its metabolite, 20alpha-dihydrodydrogesterone ( …
Human 20α-hydroxysteroid dehydrogenase (AKR1C1)-dependent biotransformation with recombinant fission yeast Schizosaccharomyces pombe.
Naumann JM, Messinger J, Bureik M. Naumann JM, et al. J Biotechnol. 2010 Oct 1;150(1):161-70. doi: 10.1016/j.jbiotec.2010.08.004. Epub 2010 Aug 19. J Biotechnol. 2010. PMID: 20727920
In this study, we have functionally expressed human AKR1C1 (20alpha-hydroxysteroid dehydrogenase) in the fission yeast Schizosaccharomyces pombe and demonstrate the ability of the resulting yeast strain to efficiently catalyze the reduction of progesterone or dydrogesterone to 20 …
In this study, we have functionally expressed human AKR1C1 (20alpha-hydroxysteroid dehydrogenase) in the fission yeast Schizosaccharomyces p …
Expression of human aldo-keto reductase 1C2 in cell lines of peritoneal endometriosis: potential implications in metabolism of progesterone and dydrogesterone and inhibition by progestins.
Beranič N, Brožič P, Brus B, Sosič I, Gobec S, Lanišnik Rižner T. Beranič N, et al. J Steroid Biochem Mol Biol. 2012 May;130(1-2):16-25. doi: 10.1016/j.jsbmb.2011.12.011. Epub 2012 Jan 8. J Steroid Biochem Mol Biol. 2012. PMID: 22245609
The recombinant enzyme catalyses reduction of progesterone to 20alpha-hydroxyprogesterone with a 10-fold lower catalytic efficiency than the major 20-ketosteroid reductase, AKR1C1. AKR1C2 also metabolises progestin dydrogesterone to its 20alpha-dihydrodydrogesterone …
The recombinant enzyme catalyses reduction of progesterone to 20alpha-hydroxyprogesterone with a 10-fold lower catalytic efficiency than the …
Dydrogesterone metabolism in human liver by aldo-keto reductases and cytochrome P450 enzymes.
Olbrich M, Weigl K, Kahler E, Mihara K. Olbrich M, et al. Xenobiotica. 2016 Oct;46(10):868-74. doi: 10.3109/00498254.2015.1134852. Epub 2016 Jan 21. Xenobiotica. 2016. PMID: 26796435
Dydrogesterone clearance was clearly higher in HLC compared to HLM. The major active metabolite 20alpha-dihydrodydrogesterone (20alpha-DHD) was only produced in HLC. 3. ...
Dydrogesterone clearance was clearly higher in HLC compared to HLM. The major active metabolite 20alpha-dihydrodydrogesterone …