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Quoted phrase not found in phrase index: "ACETOPHENETIDIN SENSITIVITY"
Page 1
Profiling cocaine by ATR-FTIR.
Marcelo MC, Mariotti KC, Ferrão MF, Ortiz RS. Marcelo MC, et al. Forensic Sci Int. 2015 Jan;246:65-71. doi: 10.1016/j.forsciint.2014.11.011. Epub 2014 Nov 22. Forensic Sci Int. 2015. PMID: 25460107
Spectra of standard solid mixtures of cocaine (salt and base), phenacetin, lidocaine and caffeine were used associated with PCA to predict qualitatively the profile of cocaine seizure. ...Accordingly with predicted profile of the salt samples, they were majority adulterate …
Spectra of standard solid mixtures of cocaine (salt and base), phenacetin, lidocaine and caffeine were used associated with PCA to pr …
Neonatal mouse model: review of methods and results.
McClain RM, Keller D, Casciano D, Fu P, MacDonald J, Popp J, Sagartz J. McClain RM, et al. Toxicol Pathol. 2001;29 Suppl:128-37. doi: 10.1080/019262301753178537. Toxicol Pathol. 2001. PMID: 11695548 Review.
In contrast, it is known not to respond to chemicals that act via epigenetic mechanisms, commonly observed in the two-year carcinogenicity studies. As such, the model has a high sensitivity and specificity in its response. Dose selection for the neonatal mode …
In contrast, it is known not to respond to chemicals that act via epigenetic mechanisms, commonly observed in the two-year carcinogenicity s …
Effects of Avitinib on CYP450 Enzyme Activity in vitro and in vivo in Rats.
Shi Y, Meng D, Wang S, Geng P, Xu T, Zhou Q, Zhou Y, Li W, Chen X. Shi Y, et al. Drug Des Devel Ther. 2021 Aug 21;15:3661-3673. doi: 10.2147/DDDT.S323186. eCollection 2021. Drug Des Devel Ther. 2021. PMID: 34456561 Free PMC article.
This study explored the in vivo and in vitro effects of avitinib on cytochrome CYP450 enzymes metabolic activity. METHODS: A rapid and sensitive ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) method was developed and validated for determining …
This study explored the in vivo and in vitro effects of avitinib on cytochrome CYP450 enzymes metabolic activity. METHODS: A rapid and se …
What makes P450s work? Searches for answers with known and new P450s.
Guengerich FP, Parikh A, Yun CH, Kim D, Nakamura K, Notley LM, Gillam EM. Guengerich FP, et al. Drug Metab Rev. 2000 Aug-Nov;32(3-4):267-81. doi: 10.1081/dmr-100102334. Drug Metab Rev. 2000. PMID: 11139129 Review.
Random mutagenesis has been developed as an approach for the study of human cytochrome P450 (P450) enzymes and their structure and function. Sensitive screening methods are critical for the success of this approach. ...With all three P450s, the rate of first electron reduc …
Random mutagenesis has been developed as an approach for the study of human cytochrome P450 (P450) enzymes and their structure and function. …
Simultaneous LC-MS-MS Determination of Lopinavir and Rifabutin in Human Plasma.
Jaiswal S, Sharma A, Shukla M, Lal J. Jaiswal S, et al. J Chromatogr Sci. 2017 Jul 1;55(6):617-624. doi: 10.1093/chromsci/bmx016. J Chromatogr Sci. 2017. PMID: 28334925
Mass spectrometric detection was performed in positive electrospray ionization mode using multiple reaction monitoring (RBT, m/z 847.7 815.4; LPV, m/z 629.6 447.4). Raloxifene and phenacetin were used as internal standards for RBT and LPV, respectively. ...
Mass spectrometric detection was performed in positive electrospray ionization mode using multiple reaction monitoring (RBT, m/z 847.7 815.4 …
Preoperative Phenacetin Metabolism Test in the Prediction of Postoperative Liver Dysfunction of Patients with Hepatocellular Carcinoma.
Pan X, Li X, Cui L, Wang Q. Pan X, et al. Med Sci Monit. 2017 May 29;23:2607-2611. doi: 10.12659/msm.905228. Med Sci Monit. 2017. PMID: 28553832 Free PMC article. Clinical Trial.
The ratio of total plasma paracetamol to phenacetin was collected in patients at 2 h after oral administration of 1.0 g phenacetin, recorded 5 days prior to surgery and on the fifth postoperative day. ...The sensitivity and specificity were 0.65 …
The ratio of total plasma paracetamol to phenacetin was collected in patients at 2 h after oral administration of 1.0 g phenacetin …
Analytical Method Development of Benzisothiazolinone, a Biocide, Using LC-MS/MS and a Pharmacokinetic Application in Rat Biological Matrices.
Jo SJ, Huang Z, Lee CB, Chae SU, Bae SH, Bae SK. Jo SJ, et al. Molecules. 2023 Jan 14;28(2):845. doi: 10.3390/molecules28020845. Molecules. 2023. PMID: 36677902 Free PMC article.
Benzisothiazolinone (BIT), a biocide widely used as a preservative in household cleaning and personal care products, is cytotoxic to lung cells and a known skin allergen in humans, which highlights the importance of assessing its toxicity and pharmacokinetics. In this study, a si …
Benzisothiazolinone (BIT), a biocide widely used as a preservative in household cleaning and personal care products, is cytotoxic to lung ce …
Assessment of a portable quadrupole-based gas chromatography mass spectrometry for seized drug analysis.
Fiorentin TR, Logan BK, Martin DM, Browne T, Rieders EF. Fiorentin TR, et al. Forensic Sci Int. 2020 Aug;313:110342. doi: 10.1016/j.forsciint.2020.110342. Epub 2020 May 20. Forensic Sci Int. 2020. PMID: 32474342
The method was validated for the identification of alprazolam, amphetamine, aminopyrine, benzocaine, caffeine, cocaine, codeine, diltiazem, ephedrine, fentanyl, fenethylline, furanylfentanyl, heroin, hydroxyzine, levamisole, lidocaine, methamphetamine, morphine, noramidopyrine (a …
The method was validated for the identification of alprazolam, amphetamine, aminopyrine, benzocaine, caffeine, cocaine, codeine, diltiazem, …
Reactions of para-substituted nitrosobenzenes with human hemoglobin.
Eyer P, Ascherl M. Eyer P, et al. Biol Chem Hoppe Seyler. 1987 Mar;368(3):285-94. doi: 10.1515/bchm3.1987.368.1.285. Biol Chem Hoppe Seyler. 1987. PMID: 3593541
The binding mode is similar to gaseous ligands and exhibits the same free energy of cooperation and sensitivity to heterotropic effectors like inositol hexaphosphate. To elucidate the electronic influence of para substituents, 4-chloronitrosobenzene, 4-nitrosotoluene and 4 …
The binding mode is similar to gaseous ligands and exhibits the same free energy of cooperation and sensitivity to heterotropic effec …
Differences in cytochrome p450-mediated pharmacokinetics between chinese and caucasian populations predicted by mechanistic physiologically based pharmacokinetic modelling.
Barter ZE, Tucker GT, Rowland-Yeo K. Barter ZE, et al. Clin Pharmacokinet. 2013 Dec;52(12):1085-100. doi: 10.1007/s40262-013-0089-y. Clin Pharmacokinet. 2013. PMID: 23818090
The drugs and the main CYPs involved in their metabolism were phenacetin (CYP1A2), desipramine (CYP2D6), tolbutamide (CYP2C9), omeprazole (CYP2C19), and alprazolam and midazolam (CYP3A). Hydroxy bupropion formation was used as a more sensitive marker of CYP2B6 activ …
The drugs and the main CYPs involved in their metabolism were phenacetin (CYP1A2), desipramine (CYP2D6), tolbutamide (CYP2C9), omepra …
17 results