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Quoted phrase not found in phrase index: "Abnormal lower motor neuron morphology"
Page 1
Regulation of cortical hyperexcitability in amyotrophic lateral sclerosis: focusing on glial mechanisms.
Xie M, Pallegar PN, Parusel S, Nguyen AT, Wu LJ. Xie M, et al. Mol Neurodegener. 2023 Oct 19;18(1):75. doi: 10.1186/s13024-023-00665-w. Mol Neurodegener. 2023. PMID: 37858176 Free PMC article. Review.
Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disorder characterized by the loss of both upper and lower motor neurons, resulting in muscle weakness, atrophy, paralysis, and eventually death. ...Both cell-autonomous (the intrinsic pro …
Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disorder characterized by the loss of both upper and lower …
Brain Magnetic Resonance Imaging (MRI) in Spinal Muscular Atrophy: A Scoping Review.
Mugisha N, Oliveira-Carneiro A, Behlim T, Oskoui M. Mugisha N, et al. J Neuromuscul Dis. 2023;10(4):493-503. doi: 10.3233/JND-221567. J Neuromuscul Dis. 2023. PMID: 37125560 Free PMC article. Review.
BACKGROUND: 5q Spinal Muscular Atrophy (SMA) is a prototypical lower motor neuron disorder. However, the characteristic early motor impairment raises the question on the scope of brain involvement with implications for further investigations on the bra …
BACKGROUND: 5q Spinal Muscular Atrophy (SMA) is a prototypical lower motor neuron disorder. However, the characteristic …
AMFR dysfunction causes autosomal recessive spastic paraplegia in human that is amenable to statin treatment in a preclinical model.
Deng R, Medico-Salsench E, Nikoncuk A, Ramakrishnan R, Lanko K, Kühn NA, van der Linde HC, Lor-Zade S, Albuainain F, Shi Y, Yousefi S, Capo I, van den Herik EM, van Slegtenhorst M, van Minkelen R, Geeven G, Mulder MT, Ruijter GJG, Lütjohann D, Jacobs EH, Houlden H, Pagnamenta AT, Metcalfe K, Jackson A, Banka S, De Simone L, Schwaede A, Kuntz N, Palculict TB, Abbas S, Umair M, AlMuhaizea M, Colak D, AlQudairy H, Alsagob M, Pereira C, Trunzo R, Karageorgou V, Bertoli-Avella AM, Bauer P, Bouman A, Hoefsloot LH, van Ham TJ, Issa M, Zaki MS, Gleeson JG, Willemsen R, Kaya N, Arold ST, Maroofian R, Sanderson LE, Barakat TS. Deng R, et al. Acta Neuropathol. 2023 Aug;146(2):353-368. doi: 10.1007/s00401-023-02579-9. Epub 2023 Apr 29. Acta Neuropathol. 2023. PMID: 37119330 Free PMC article.
Hereditary spastic paraplegias (HSP) are rare, inherited neurodegenerative or neurodevelopmental disorders that mainly present with lower limb spasticity and muscle weakness due to motor neuron dysfunction. ...The absence of AMFR disturbs lipid homeostasis, c …
Hereditary spastic paraplegias (HSP) are rare, inherited neurodegenerative or neurodevelopmental disorders that mainly present with lower …
TDP-43 pathology and functional deficits in wild-type and ALS/FTD mutant cyclin F mouse models.
van Hummel A, Sabale M, Przybyla M, van der Hoven J, Chan G, Feiten AF, Chung RS, Ittner LM, Ke YD. van Hummel A, et al. Neuropathol Appl Neurobiol. 2023 Apr;49(2):e12902. doi: 10.1111/nan.12902. Neuropathol Appl Neurobiol. 2023. PMID: 36951214 Free PMC article.
AIMS: Amyotrophic lateral sclerosis (ALS) is characterised by a progressive loss of upper and lower motor neurons leading to muscle weakness and eventually death. ...CONCLUSIONS: In summary, CCNF expression in mice reproduces clinical presentations of ALS, in …
AIMS: Amyotrophic lateral sclerosis (ALS) is characterised by a progressive loss of upper and lower motor neurons leadi …
Neurological and developmental effects of HIV and AIDS in children and adolescents.
Mitchell W. Mitchell W. Ment Retard Dev Disabil Res Rev. 2001;7(3):211-6. doi: 10.1002/mrdd.1029. Ment Retard Dev Disabil Res Rev. 2001. PMID: 11553937 Review.
Infected infants may manifest early, catastrophic encephalopathy, with loss of brain growth, motor abnormalities, and cognitive dysfunction. Even without evidence of AIDS, infected infants score lower than serorevertors on developmental measures, parti …
Infected infants may manifest early, catastrophic encephalopathy, with loss of brain growth, motor abnormalities, and cognitiv …
The impairment of cholesterol metabolism in Huntington disease.
Leoni V, Caccia C. Leoni V, et al. Biochim Biophys Acta. 2015 Aug;1851(8):1095-105. doi: 10.1016/j.bbalip.2014.12.018. Epub 2015 Jan 14. Biochim Biophys Acta. 2015. PMID: 25596342 Review.
Huntington disease (HD), an autosomal dominant neurodegenerative disorder caused by an abnormal expansion of CAG trinucleotide repeat in the Huntingtin (HTT) gene, is characterized by extensive neurodegeneration of striatum and cortex and severe diffuse atrophy at MRI. ... …
Huntington disease (HD), an autosomal dominant neurodegenerative disorder caused by an abnormal expansion of CAG trinucleotide repeat …
Motor neuron involvement in anti-Ma2-associated paraneoplastic neurological syndrome.
Vogrig A, Joubert B, Maureille A, Thomas L, Bernard E, Streichenberger N, Cotton F, Ducray F, Honnorat J. Vogrig A, et al. J Neurol. 2019 Feb;266(2):398-410. doi: 10.1007/s00415-018-9143-x. Epub 2018 Nov 29. J Neurol. 2019. PMID: 30498914
OBJECTIVE: To present clinical, radiological, and pathological features of a cohort of patients with motor neuron involvement in association with anti-Ma2 antibodies (Ma2-Ab). ...CONCLUSIONS: Motor neuron involvement could complicate Ma2-Ab-associated …
OBJECTIVE: To present clinical, radiological, and pathological features of a cohort of patients with motor neuron involvement …
Lower Motor Neuron Abnormality in Chronic Cervical Spinal Cord Injury: Implications for Nerve Transfer Surgery.
Berger MJ, Robinson L, Krauss EM. Berger MJ, et al. J Neurotrauma. 2022 Feb;39(3-4):259-265. doi: 10.1089/neu.2020.7579. Epub 2021 Apr 1. J Neurotrauma. 2022. PMID: 33626968
Nerve transfer surgery (NT) constitutes an exciting option to improve upper limb functions in chronic spinal cord injury (SCI), but requires intact sublesional lower motor neuron (LMN) health. The purpose of this study was to characterize patterns of LMN a …
Nerve transfer surgery (NT) constitutes an exciting option to improve upper limb functions in chronic spinal cord injury (SCI), but requires …
Stereological and electrophysiological evaluation of autonomic involvement in amyotrophic lateral sclerosis.
Ozturk R, Karlsson P, Hu X, Akdeniz E, Surucu S, Isak B. Ozturk R, et al. Neurophysiol Clin. 2022 Nov;52(6):446-458. doi: 10.1016/j.neucli.2022.08.003. Epub 2022 Sep 23. Neurophysiol Clin. 2022. PMID: 36155704
SSR and resting HRV were repeated in the ALS patient cohort one year later. RESULTS: COMPASS-31 total score, gastrointestinal- and urinary-sub scores were higher in ALS patients than controls (P = 0.004, P = 0.005, and P = 0.049, respectively). ...However, the degen …
SSR and resting HRV were repeated in the ALS patient cohort one year later. RESULTS: COMPASS-31 total score, gastrointestinal- and ur …
Early abnormalities in transgenic mouse models of amyotrophic lateral sclerosis.
Durand J, Amendola J, Bories C, Lamotte d'Incamps B. Durand J, et al. J Physiol Paris. 2006 Mar-May;99(2-3):211-20. doi: 10.1016/j.jphysparis.2005.12.014. Epub 2006 Jan 30. J Physiol Paris. 2006. PMID: 16448809 Review.
We will focus here on the earlier abnormalities observed in superoxide dismutase 1 (SOD1) mutant mice. Several hypotheses have been advanced to explain the selective loss of motor neurons such as apoptosis, neurofilament disorganisation, oxidative stre …
We will focus here on the earlier abnormalities observed in superoxide dismutase 1 (SOD1) mutant mice. Several hypotheses have …
161 results