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Quoted phrase not found in phrase index: "Abnormal sperm axoneme morphology"
Page 1
Axonemal structures reveal mechanoregulatory and disease mechanisms.
Walton T, Gui M, Velkova S, Fassad MR, Hirst RA, Haarman E, O'Callaghan C, Bottier M, Burgoyne T, Mitchison HM, Brown A. Walton T, et al. Nature. 2023 Jun;618(7965):625-633. doi: 10.1038/s41586-023-06140-2. Epub 2023 May 31. Nature. 2023. PMID: 37258679 Free PMC article.
Here we capitalize on recent developments in artificial intelligence-enabled structure prediction and cryo-electron microscopy (cryo-EM) to determine the structure of the 96-nm modular repeats of axonemes from the flagella of the alga Chlamydomonas reinhardtii and h …
Here we capitalize on recent developments in artificial intelligence-enabled structure prediction and cryo-electron microscopy (cryo- …
Bi-allelic variants in DNHD1 cause flagellar axoneme defects and asthenoteratozoospermia in humans and mice.
Tan C, Meng L, Lv M, He X, Sha Y, Tang D, Tan Y, Hu T, He W, Tu C, Nie H, Zhang H, Du J, Lu G, Fan LQ, Cao Y, Lin G, Tan YQ. Tan C, et al. Am J Hum Genet. 2022 Jan 6;109(1):157-171. doi: 10.1016/j.ajhg.2021.11.022. Epub 2021 Dec 20. Am J Hum Genet. 2022. PMID: 34932939 Free PMC article.
Asthenoteratozoospermia, defined as reduced sperm motility and abnormal sperm morphology, is a disorder with considerable genetic heterogeneity. ...In sperm from fertile men, DNHD1 was localized to the entire flagella of the normal sperm; …
Asthenoteratozoospermia, defined as reduced sperm motility and abnormal sperm morphology, is a disorder with con …
Biallelic mutations in CFAP54 cause male infertility with severe MMAF and NOA.
Tian S, Tu C, He X, Meng L, Wang J, Tang S, Gao Y, Liu C, Wu H, Zhou Y, Lv M, Lin G, Jin L, Cao Y, Tang D, Zhang F, Tan YQ. Tian S, et al. J Med Genet. 2023 Aug;60(8):827-834. doi: 10.1136/jmg-2022-108887. Epub 2023 Jan 2. J Med Genet. 2023. PMID: 36593121
All of the identified variants were absent or extremely rare in the public human genome databases and predicted to be damaging by bioinformatic tools. The men harbouring CFAP54 mutations exhibited abnormal sperm morphology, reduced sperm concent …
All of the identified variants were absent or extremely rare in the public human genome databases and predicted to be damaging by bio …
Novel FSIP2 Variants Induce Super-Length Mitochondrial Sheath and Asthenoteratozoospermia in Humans.
Lv M, Tang D, Yu H, Geng H, Zhou Y, Shao Z, Li K, Gao Y, Guo S, Xu C, Tan Q, Liu C, Guo R, Wu H, Duan Z, Zhang J, Wang G, Hua R, Fu F, Wang K, Xu Y, Zhou P, Wei Z, Zhang F, Cao Y, He X. Lv M, et al. Int J Biol Sci. 2023 Jan 1;19(2):393-411. doi: 10.7150/ijbs.76051. eCollection 2023. Int J Biol Sci. 2023. PMID: 36632462 Free PMC article.
Deleterious FSIP2 variations caused severe disassembly of the fibrous sheath and axonemal defects. Intriguingly, spermatozoa in our study manifested "super-length" mitochondrial sheaths, increased levels of the mitochondrial sheath outer membrane protein TOMM20 and …
Deleterious FSIP2 variations caused severe disassembly of the fibrous sheath and axonemal defects. Intriguingly, spermatozoa i …
LRRC46 Accumulates at the Midpiece of Sperm Flagella and Is Essential for Spermiogenesis and Male Fertility in Mouse.
Yin Y, Mu W, Yu X, Wang Z, Xu K, Wu X, Cai Y, Zhang M, Lu G, Chan WY, Ma J, Huang T, Liu H. Yin Y, et al. Int J Mol Sci. 2022 Jul 31;23(15):8525. doi: 10.3390/ijms23158525. Int J Mol Sci. 2022. PMID: 35955660 Free PMC article.
The sperm flagellum is essential for male fertility. Multiple morphological abnormalities of the sperm flagella (MMAF) is a severe form of asthenoteratozoospermia. ...Thus, our study provides insights for understanding developmental processes underlying sp …
The sperm flagellum is essential for male fertility. Multiple morphological abnormalities of the sperm flagella (MMAF) …
An illustration of human sperm morphology and their functional ability among different group of subfertile males.
Sunanda P, Panda B, Dash C, Padhy RN, Routray P. Sunanda P, et al. Andrology. 2018 Sep;6(5):680-689. doi: 10.1111/andr.12500. Epub 2018 Jun 29. Andrology. 2018. PMID: 29959832 Free article.
Student's t-test showed no significant changes in mean values of condensation defects in abnormal semen samples in comparison with the normal group. Condensation defects were observed in normal spermatozoa too, which was negatively associated with the rate of …
Student's t-test showed no significant changes in mean values of condensation defects in abnormal semen samples in comparison with th …
Bi-allelic mutations of DNAH10 cause primary male infertility with asthenoteratozoospermia in humans and mice.
Tu C, Cong J, Zhang Q, He X, Zheng R, Yang X, Gao Y, Wu H, Lv M, Gu Y, Lu S, Liu C, Tian S, Meng L, Wang W, Tan C, Nie H, Li D, Zhang H, Gong F, Hu L, Lu G, Xu W, Lin G, Zhang F, Cao Y, Tan YQ. Tu C, et al. Am J Hum Genet. 2021 Aug 5;108(8):1466-1477. doi: 10.1016/j.ajhg.2021.06.010. Epub 2021 Jul 7. Am J Hum Genet. 2021. PMID: 34237282 Free PMC article.
Multiple morphological abnormalities of the sperm flagella (MMAF)-induced asthenoteratozoospermia is a common cause of male infertility. ...Immunostaining analysis indicated that DNAH10 localized to the entire sperm flagellum of control spermatozoa. In …
Multiple morphological abnormalities of the sperm flagella (MMAF)-induced asthenoteratozoospermia is a common cause of male in …
Clinical and genetic aspects of primary ciliary dyskinesia/Kartagener syndrome.
Leigh MW, Pittman JE, Carson JL, Ferkol TW, Dell SD, Davis SD, Knowles MR, Zariwala MA. Leigh MW, et al. Genet Med. 2009 Jul;11(7):473-87. doi: 10.1097/GIM.0b013e3181a53562. Genet Med. 2009. PMID: 19606528 Free PMC article. Review.
The respiratory manifestations of primary ciliary dyskinesia (chronic bronchitis leading to bronchiectasis, chronic rhino-sinusitis, and chronic otitis media)reflect impaired mucociliary clearance owing to defective axonemal structure. Ciliary ultrastructural analysis in m …
The respiratory manifestations of primary ciliary dyskinesia (chronic bronchitis leading to bronchiectasis, chronic rhino-sinusitis, and chr …
Novel loss-of-function variants in DNAH17 cause multiple morphological abnormalities of the sperm flagella in humans and mice.
Zhang B, Khan I, Liu C, Ma A, Khan A, Zhang Y, Zhang H, Kakakhel MBS, Zhou J, Zhang W, Li Y, Ali A, Jiang X, Murtaza G, Khan R, Zubair M, Yuan L, Khan M, Wang L, Zhang F, Wang X, Ma H, Shi Q. Zhang B, et al. Clin Genet. 2021 Jan;99(1):176-186. doi: 10.1111/cge.13866. Epub 2020 Nov 2. Clin Genet. 2021. PMID: 33070343
Transmission electron microscope analyses revealed completely disorganized axonemal structure as the predominant anomaly and increased frequencies of missings of microtubule doublet(s) 4-7 in sperm flagella of patients. Similar to those found in patients, Dnah17(-/- …
Transmission electron microscope analyses revealed completely disorganized axonemal structure as the predominant anomaly and increase …
Homozygous SPAG6 variants can induce nonsyndromic asthenoteratozoospermia with severe MMAF.
Xu C, Tang D, Shao Z, Geng H, Gao Y, Li K, Tan Q, Wang G, Wang C, Wu H, Li G, Lv M, He X, Cao Y. Xu C, et al. Reprod Biol Endocrinol. 2022 Mar 1;20(1):41. doi: 10.1186/s12958-022-00916-3. Reprod Biol Endocrinol. 2022. PMID: 35232447 Free PMC article.
SPAG6 is a core axonemal component that plays a critical role in the formation of cilia and sperm flagella. ...Scanning and transmission electron microscopy (S/TEM) was performed to observe the ultrastructural defects of the sperm flagella. Western blo …
SPAG6 is a core axonemal component that plays a critical role in the formation of cilia and sperm flagella. ...Scanning and tr …
57 results