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Quoted phrase not found in phrase index: "Abnormal thymus morphology"
Page 1
ITMIG Classification of Mediastinal Compartments and Multidisciplinary Approach to Mediastinal Masses.
Carter BW, Benveniste MF, Madan R, Godoy MC, de Groot PM, Truong MT, Rosado-de-Christenson ML, Marom EM. Carter BW, et al. Radiographics. 2017 Mar-Apr;37(2):413-436. doi: 10.1148/rg.2017160095. Epub 2017 Jan 27. Radiographics. 2017. PMID: 28129068 Review.
This new definition plays an important role in identification and characterization of mediastinal abnormalities, which, although uncommon and encompassing a wide variety of entities, can often be diagnosed with confidence based on location and imaging features alone. ...In …
This new definition plays an important role in identification and characterization of mediastinal abnormalities, which, although unco …
Pembrolizumab in patients with thymic carcinoma: a single-arm, single-centre, phase 2 study.
Giaccone G, Kim C, Thompson J, McGuire C, Kallakury B, Chahine JJ, Manning M, Mogg R, Blumenschein WM, Tan MT, Subramaniam DS, Liu SV, Kaplan IM, McCutcheon JN. Giaccone G, et al. Lancet Oncol. 2018 Mar;19(3):347-355. doi: 10.1016/S1470-2045(18)30062-7. Epub 2018 Jan 26. Lancet Oncol. 2018. PMID: 29395863 Free PMC article. Clinical Trial.
Key inclusion criteria were an Eastern Cooperative Oncology Group performance status of 0-2, no history of autoimmune disease or other malignancy requiring treatment or laboratory abnormality, and adequate organ function. Patients received 200 mg of pembrolizumab every 3 w …
Key inclusion criteria were an Eastern Cooperative Oncology Group performance status of 0-2, no history of autoimmune disease or other malig …
Autoantibodies against type I IFNs in humans with alternative NF-κB pathway deficiency.
Le Voyer T, Parent AV, Liu X, Cederholm A, Gervais A, Rosain J, Nguyen T, Perez Lorenzo M, Rackaityte E, Rinchai D, Zhang P, Bizien L, Hancioglu G, Ghillani-Dalbin P, Charuel JL, Philippot Q, Gueye MS, Maglorius Renkilaraj MRL, Ogishi M, Soudée C, Migaud M, Rozenberg F, Momenilandi M, Riller Q, Imberti L, Delmonte OM, Müller G, Keller B, Orrego J, Franco Gallego WA, Rubin T, Emiroglu M, Parvaneh N, Eriksson D, Aranda-Guillen M, Berrios DI, Vong L, Katelaris CH, Mustillo P, Raedler J, Bohlen J, Bengi Celik J, Astudillo C, Winter S; NF-κB Consortium; COVID Human Genetic Effort; McLean C, Guffroy A, DeRisi JL, Yu D, Miller C, Feng Y, Guichard A, Béziat V, Bustamante J, Pan-Hammarström Q, Zhang Y, Rosen LB, Holland SM, Bosticardo M, Kenney H, Castagnoli R, Slade CA, Boztuğ K, Mahlaoui N, Latour S, Abraham RS, Lougaris V, Hauck F, Sediva A, Atschekzei F, Sogkas G, Poli MC, Slatter MA, Palterer B, Keller MD, Pinzon-Charry A, Sullivan A, Droney L, Suan D, Wong M, Kane A, Hu H, Ma C, Grombiříková H, Ciznar P, Dalal I, Aladjidi N, Hie M, Lazaro E, Franco J, Keles S, Malphettes M, Pasquet M, Maccari ME, Meinhardt A, Ikinciogullari A, Shahrooei M, Celmeli F, Frosk P, Goodnow CC, Gray PE, Bel… See abstract for full author list ➔ Le Voyer T, et al. Nature. 2023 Nov;623(7988):803-813. doi: 10.1038/s41586-023-06717-x. Epub 2023 Nov 8. Nature. 2023. PMID: 37938781 Free PMC article.
In contrast to patients with APS-1, patients with disorders of NIK, RELB or NF-kappaB2 have very few tissue-specific autoantibodies. However, their thymuses have an abnormal structure, with few AIRE-expressing medullary thymic epithelial cells. ...
In contrast to patients with APS-1, patients with disorders of NIK, RELB or NF-kappaB2 have very few tissue-specific autoantibodies. However …
Obesity-induced thymic involution and cancer risk.
Lagou MK, Karagiannis GS. Lagou MK, et al. Semin Cancer Biol. 2023 Aug;93:3-19. doi: 10.1016/j.semcancer.2023.04.008. Epub 2023 Apr 22. Semin Cancer Biol. 2023. PMID: 37088128 Free article. Review.
A key mechanism underlying such increased cancer risk is the thymus-dependent debilitation of adaptive immunity, which is responsible for orchestrating immunoediting mechanisms and tumor immune surveillance. ...This knowledge could be especially relevant in the context of …
A key mechanism underlying such increased cancer risk is the thymus-dependent debilitation of adaptive immunity, which is responsible …
Primary and secondary defects of the thymus.
Dinges SS, Amini K, Notarangelo LD, Delmonte OM. Dinges SS, et al. Immunol Rev. 2024 Mar;322(1):178-211. doi: 10.1111/imr.13306. Epub 2024 Jan 16. Immunol Rev. 2024. PMID: 38228406 Review.
Severe congenital disorders of thymic development (athymia) can be fatal if left untreated due to infections, and thymic tissue implantation is the only cure. ...The thymus is sensitive to injury elicited from a variety of endogenous and exogenous factors, and its s …
Severe congenital disorders of thymic development (athymia) can be fatal if left untreated due to infections, and thymic tissue impla …
Unraveling molecular networks in thymic epithelial tumors: deciphering the unique signatures.
Zhang X, Zhang P, Cong A, Feng Y, Chi H, Xia Z, Tang H. Zhang X, et al. Front Immunol. 2023 Oct 2;14:1264325. doi: 10.3389/fimmu.2023.1264325. eCollection 2023. Front Immunol. 2023. PMID: 37849766 Free PMC article. Review.
This review delves into the complex molecular networks of TETs, highlighting key aspects such as chromosomal abnormalities, molecular subtypes, aberrant gene mutations and expressions, structural gene rearrangements, and epigenetic changes. ...
This review delves into the complex molecular networks of TETs, highlighting key aspects such as chromosomal abnormalities, molecular …
Current and Future Therapeutic Approaches for Thymic Stromal Cell Defects.
Kreins AY, Bonfanti P, Davies EG. Kreins AY, et al. Front Immunol. 2021 Mar 18;12:655354. doi: 10.3389/fimmu.2021.655354. eCollection 2021. Front Immunol. 2021. PMID: 33815417 Free PMC article. Review.
Inborn errors of thymic stromal cell development and function lead to impaired T-cell development resulting in a susceptibility to opportunistic infections and autoimmunity. In their most severe form, congenital athymia, these disorders are life-threatening if left untreat …
Inborn errors of thymic stromal cell development and function lead to impaired T-cell development resulting in a susceptibility to opportuni …
Persistent Left Superior Vena Cava in Fetuses: An Autopsy Series.
Ramakrishnan D, Chidambarathanu S, Murli L, Micheal J, Jagadeesh S, Suresh I, Seshadri S. Ramakrishnan D, et al. Fetal Pediatr Pathol. 2017 Aug;36(4):304-310. doi: 10.1080/15513815.2017.1324546. Epub 2017 Jun 1. Fetal Pediatr Pathol. 2017. PMID: 28569558
Anomalies of cardiovascular, respiratory, genitourinary and musculoskeletal, hypoplastic thymus and single umbilical artery were significantly higher in the study group. ...
Anomalies of cardiovascular, respiratory, genitourinary and musculoskeletal, hypoplastic thymus and single umbilical artery were sign …
Correlation of first-trimester thymus size with chromosomal anomalies.
Kleemann S, Koch R, Schmitz R, Köster HA, Braun J, Steinhard J, Oelmeier K, Klockenbusch W, Möllers M. Kleemann S, et al. J Perinat Med. 2021 Feb 10;49(5):604-613. doi: 10.1515/jpm-2020-0599. Print 2021 Jun 25. J Perinat Med. 2021. PMID: 33561911
The included cases were subdivided into six groups: (1) trisomy 21, (2) trisomy 18, (3) trisomy 13, (4) Turner syndrome, (5) triploidy and (6) normal controls. Thymus size measurements were adjusted to the week of gestation, which was determined by ultrasound using crown-r …
The included cases were subdivided into six groups: (1) trisomy 21, (2) trisomy 18, (3) trisomy 13, (4) Turner syndrome, (5) triploidy and ( …
207 results