Genetic variants in COL2A1, COL11A2, and IRF6 contribute risk to nonsyndromic cleft palate.
Nikopensius T, Jagomägi T, Krjutskov K, Tammekivi V, Saag M, Prane I, Piekuse L, Akota I, Barkane B, Krumina A, Ambrozaityte L, Matuleviciene A, Kucinskiene ZA, Lace B, Kucinskas V, Metspalu A.
Nikopensius T, et al.
Birth Defects Res A Clin Mol Teratol. 2010 Sep;88(9):748-56. doi: 10.1002/bdra.20700.
Birth Defects Res A Clin Mol Teratol. 2010.
PMID: 20672350
The strongest associations were found for IRF6 haplotype rs17389541/rs9430018 GT (p = 2.23 10(-4)) and COL2A1 haplotype rs12822608/rs6823 GC (p = 3.68 10(-4)). The strongest epistatic interactions were observed between MSX1 and BMP2, FGF1 and PVRL2, and COL2A1 and FGF2 gen …
The strongest associations were found for IRF6 haplotype rs17389541/rs9430018 GT (p = 2.23 10(-4)) and COL2A1 haplotype rs12822608/rs6823 GC …