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Quoted phrase not found in phrase index: "Abnormal microglia morphology"
Page 1
SPECT and PET imaging in Alzheimer's disease.
Valotassiou V, Malamitsi J, Papatriantafyllou J, Dardiotis E, Tsougos I, Psimadas D, Alexiou S, Hadjigeorgiou G, Georgoulias P. Valotassiou V, et al. Ann Nucl Med. 2018 Nov;32(9):583-593. doi: 10.1007/s12149-018-1292-6. Epub 2018 Aug 20. Ann Nucl Med. 2018. PMID: 30128693 Review.
Beta-amyloid (Abeta) deposition and neurofibrillary tangles (NFTs) of abnormal hyperphosphorylated tau protein are the pathological hallmarks of the disease, accompanied by other pathological processes such as microglia activation. ...Intense efforts in radiopharmac …
Beta-amyloid (Abeta) deposition and neurofibrillary tangles (NFTs) of abnormal hyperphosphorylated tau protein are the pathological h …
Microglial activation and tau propagate jointly across Braak stages.
Pascoal TA, Benedet AL, Ashton NJ, Kang MS, Therriault J, Chamoun M, Savard M, Lussier FZ, Tissot C, Karikari TK, Ottoy J, Mathotaarachchi S, Stevenson J, Massarweh G, Schöll M, de Leon MJ, Soucy JP, Edison P, Blennow K, Zetterberg H, Gauthier S, Rosa-Neto P. Pascoal TA, et al. Nat Med. 2021 Sep;27(9):1592-1599. doi: 10.1038/s41591-021-01456-w. Epub 2021 Aug 26. Nat Med. 2021. PMID: 34446931
Regression analysis revealed that the longitudinal tau propagation pathways depended on the baseline microglia network rather than the tau network circuits. The co-occurrence of Abeta, tau and microglia abnormalities was the strongest predictor of cogn …
Regression analysis revealed that the longitudinal tau propagation pathways depended on the baseline microglia network rather than th …
Metabolic Reprogramming of Microglia in Sepsis-Associated Encephalopathy: Insights from Neuroinflammation.
Gao S, Jiang Y, Chen Z, Zhao X, Gu J, Wu H, Liao Y, Sun H, Wang J, Chen W. Gao S, et al. Curr Neuropharmacol. 2023;21(9):1992-2005. doi: 10.2174/1570159X21666221216162606. Curr Neuropharmacol. 2023. PMID: 36529923 Free PMC article. Review.
It is a relatively common complication of sepsis associated with poor patient prognosis and mortality. The pathogenesis of SAE involves neuroinflammatory responses, neurotransmitter dysfunction, blood-brain barrier (BBB) disruption, abnormal blood flow regulation, e …
It is a relatively common complication of sepsis associated with poor patient prognosis and mortality. The pathogenesis of SAE involv …
Mild Hypoxia Accelerates Cerebral Cavernous Malformation Disease Through CX3CR1-CX3CL1 Signaling.
Frias-Anaya E, Gallego-Gutierrez H, Gongol B, Weinsheimer S, Lai CC, Orecchioni M, Sriram A, Bui CM, Nelsen B, Hale P, Pham A, Shenkar R, DeBiasse D, Lightle R, Girard R, Li Y, Srinath A, Daneman R, Nudleman E, Sun H, Guma M, Dubrac A, Mesarwi OA, Ley K, Kim H, Awad IA, Ginsberg MH, Lopez-Ramirez MA. Frias-Anaya E, et al. Arterioscler Thromb Vasc Biol. 2024 Jun;44(6):1246-1264. doi: 10.1161/ATVBAHA.123.320367. Epub 2024 Apr 25. Arterioscler Thromb Vasc Biol. 2024. PMID: 38660801
In particular, this pathway regulates the recruitment and activation of microglia and other immune cells in CCM lesions, which leads to lesion growth and thrombosis. ...These results establish CX3CR1 as a genetic marker for patient stratification and a potential predict …
In particular, this pathway regulates the recruitment and activation of microglia and other immune cells in CCM lesions, which leads …
Microglia-Mediated Neurovascular Unit Dysfunction in Alzheimer's Disease.
Huang W, Xia Q, Zheng F, Zhao X, Ge F, Xiao J, Liu Z, Shen Y, Ye K, Wang D, Li Y. Huang W, et al. J Alzheimers Dis. 2023;94(s1):S335-S354. doi: 10.3233/JAD-221064. J Alzheimers Dis. 2023. PMID: 36683511 Free PMC article. Review.
Therefore, we review the mechanisms of microglia-mediated NVU dysfunction in AD. Furthermore, existing therapeutic advancements aimed at restoring the function of microglia and the NVU in AD are discussed. Finally, we predict the role of pericytes in micro …
Therefore, we review the mechanisms of microglia-mediated NVU dysfunction in AD. Furthermore, existing therapeutic advancements aimed …
Investigating microglia-brain tumor cell interactions in vivo in the larval zebrafish brain.
Astell KR, Sieger D. Astell KR, et al. Methods Cell Biol. 2017;138:593-626. doi: 10.1016/bs.mcb.2016.10.001. Epub 2016 Oct 31. Methods Cell Biol. 2017. PMID: 28129859 Review.
Glioblastoma tumors are highly resistant to multimodal therapies and there is significant patient mortality within the first two years after prognosis. At present clinical treatments are palliative, not curative. Glioblastomas contain a high number of microglia and …
Glioblastoma tumors are highly resistant to multimodal therapies and there is significant patient mortality within the first two years after …
Glial pathology in bipolar disorder: potential therapeutic implications.
Dong XH, Zhen XC. Dong XH, et al. CNS Neurosci Ther. 2015 May;21(5):393-7. doi: 10.1111/cns.12390. Epub 2015 Mar 9. CNS Neurosci Ther. 2015. PMID: 25753128 Free PMC article. Review.
Postmortem studies have repeatedly demonstrated the alterations in glial cells and its functions in patients with BD. The activated microglia and inflammatory cytokines are proposed to be the potential biomarkers that may help to predict disease exacerbation in BD. …
Postmortem studies have repeatedly demonstrated the alterations in glial cells and its functions in patients with BD. The activated micro …
Bilateral Rasmussen encephalitis.
Guan Y, Luan G, Zhou J, Liu X. Guan Y, et al. Epilepsy Behav. 2011 Feb;20(2):398-403. doi: 10.1016/j.yebeh.2010.12.004. Epub 2011 Jan 8. Epilepsy Behav. 2011. PMID: 21216675
The pathology of the left frontoparietal lobe biopsy of the abnormal MRI signal showed typical neuronal loss, abundant lymphocytic infiltration into the perivascular space, and numerous microglial nodules. Bipolar electrocoagulation on functional cortexes, which failed to …
The pathology of the left frontoparietal lobe biopsy of the abnormal MRI signal showed typical neuronal loss, abundant lymphocytic in …
Visualising microglial activation in vivo.
Banati RB. Banati RB. Glia. 2002 Nov;40(2):206-217. doi: 10.1002/glia.10144. Glia. 2002. PMID: 12379908 Review.
In health, microglia reside as quiescent guardian cells ubiquitously, but isolated without any cell-cell contacts amongst themselves, throughout the normal CNS. In disease, however, they act as swift "sensors" for pathological events, including subtle ones without any obvi …
In health, microglia reside as quiescent guardian cells ubiquitously, but isolated without any cell-cell contacts amongst themselves, …
Microglial activation and progressive brain changes in schizophrenia.
Laskaris LE, Di Biase MA, Everall I, Chana G, Christopoulos A, Skafidas E, Cropley VL, Pantelis C. Laskaris LE, et al. Br J Pharmacol. 2016 Feb;173(4):666-80. doi: 10.1111/bph.13364. Epub 2016 Jan 8. Br J Pharmacol. 2016. PMID: 26455353 Free PMC article. Review.
Schizophrenia is a debilitating disorder that typically begins in adolescence and is characterized by perceptual abnormalities, delusions, cognitive and behavioural disturbances and functional impairments. ...Schizophrenia is associated with structural brain abnormaliti …
Schizophrenia is a debilitating disorder that typically begins in adolescence and is characterized by perceptual abnormalities, delus …
73 results