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Quoted phrase not found in phrase index: "Abnormal platelet shape"
Page 1
Disconnect between COX-2 selective inhibition and cardiovascular risk in preclinical models.
Koshman YE, Bielinski AL, Bird BM, Green JR, Kowalkowski KL, Lai-Zhang J, Mahalingaiah PK, Sawicki JW, Talaty NN, Wilsey AS, Zafiratos MT, Van Vleet TR. Koshman YE, et al. J Pharmacol Toxicol Methods. 2023 Mar-Apr;120:107251. doi: 10.1016/j.vascn.2023.107251. Epub 2023 Feb 13. J Pharmacol Toxicol Methods. 2023. PMID: 36792039 Clinical Trial.
Several potential mechanisms of COX-2-mediated myocardial infarctions have been considered including, effects on platelet stickiness/aggregation, vasal tone and blood pressure, and endothelial cell activation. ...Compounds were screened for inhibition of COX-2 vs CO …
Several potential mechanisms of COX-2-mediated myocardial infarctions have been considered including, effects on platelet stickiness/ …
Pathogenesis of hypoxemia.
Chantharaksri U, Tonsuwonnont W, Fucharoen S, Wasi P. Chantharaksri U, et al. Southeast Asian J Trop Med Public Health. 1992;23 Suppl 2:32-5. Southeast Asian J Trop Med Public Health. 1992. PMID: 1298990
Thrombocytosis and morphological changes in shape and size of circulating platelets are commonly found in splenectomized thalassemia patients. Functional abnormalities of the platelets are evidently related to their fragile nature. ...
Thrombocytosis and morphological changes in shape and size of circulating platelets are commonly found in splenectomized thala …
A finite-element model of granular serotonin exocytosis.
Datta A, Haynes CL, Barocas VH. Datta A, et al. Integr Biol (Camb). 2017 Mar 1;9(3):248-256. doi: 10.1039/c6ib00226a. Epub 2017 Feb 7. Integr Biol (Camb). 2017. PMID: 28168257
Serotonin, for example, is involved in the regulation of behavior, cognitive function, and hemostasis. Understanding serotonin release from platelet granules can provide valuable fundamental information about the exocytotic process and help elucidate potential abnormali …
Serotonin, for example, is involved in the regulation of behavior, cognitive function, and hemostasis. Understanding serotonin release from …
Platelet size and shape in hereditary giant platelet syndromes on blood smear and in suspension: evidence for two types of abnormalities.
Milton JG, Hutton RA, Tuddenham EG, Frojmovic MM. Milton JG, et al. J Lab Clin Med. 1985 Sep;106(3):326-35. J Lab Clin Med. 1985. PMID: 4031633
In whole blood platelet shape is normal for HGPS, but in PRP for 10 of 16 patients with HGPS there is a decrease in the proportion of smooth, discoid-shaped platelets (discocytes [D]). ...Our observations point to two distinct abnormalities …
In whole blood platelet shape is normal for HGPS, but in PRP for 10 of 16 patients with HGPS there is a decrease in the …
Serotonin, histamine and platelets in vascular disease with special reference to peripheral vascular disease.
Barradas MA, Mikhailidis DP. Barradas MA, et al. Braz J Med Biol Res. 1992;25(11):1063-76. Braz J Med Biol Res. 1992. PMID: 1342586 Review.
Studies involving patients with peripheral vascular disease (PVD) where abnormalities in platelet function (platelet aggregation and platelet shape change) and in bioamine status (vascular, platelet and plasma bioamine concentrations) are …
Studies involving patients with peripheral vascular disease (PVD) where abnormalities in platelet function (platelet ag …
Platelet count is associated with cardiovascular disease, cancer and mortality: A population-based cohort study.
Vinholt PJ, Hvas AM, Frederiksen H, Bathum L, Jørgensen MK, Nybo M. Vinholt PJ, et al. Thromb Res. 2016 Dec;148:136-142. doi: 10.1016/j.thromres.2016.08.012. Epub 2016 Aug 20. Thromb Res. 2016. PMID: 27586589
While abnormal platelet counts are associated with mortality and morbidity, it is unclear whether it also apply to platelet counts within reference range. ...Cox proportional hazard regression was conducted with adjustment for age, sex, smoking status, haemog …
While abnormal platelet counts are associated with mortality and morbidity, it is unclear whether it also apply to platelet …
Platelet adhesive dynamics. Part I: characterization of platelet hydrodynamic collisions and wall effects.
Mody NA, King MR. Mody NA, et al. Biophys J. 2008 Sep;95(5):2539-55. doi: 10.1529/biophysj.107.127670. Epub 2008 May 30. Biophys J. 2008. PMID: 18515387 Free PMC article.
Abnormally high shear stresses encountered in vivo induce spontaneous activation of blood platelets and formation of aggregates, even in the absence of vascular injury. ...Physical quantities characterizing the adhesion probabilities between colliding plat …
Abnormally high shear stresses encountered in vivo induce spontaneous activation of blood platelets and formation of ag …
GFI1B mutation causes a bleeding disorder with abnormal platelet function.
Stevenson WS, Morel-Kopp MC, Chen Q, Liang HP, Bromhead CJ, Wright S, Turakulov R, Ng AP, Roberts AW, Bahlo M, Ward CM. Stevenson WS, et al. J Thromb Haemost. 2013 Nov;11(11):2039-47. doi: 10.1111/jth.12368. J Thromb Haemost. 2013. PMID: 23927492 Free article.
This mutation alters the transcriptional activity of the protein, resulting in a reduction in platelet alpha-granule content and aberrant expression of key platelet proteins. CONCLUSIONS: GFI1B mutation represents a novel human bleeding disorder, and the described p …
This mutation alters the transcriptional activity of the protein, resulting in a reduction in platelet alpha-granule content and aber …
Functional characterization of a novel GFI1B mutation causing congenital macrothrombocytopenia.
Kitamura K, Okuno Y, Yoshida K, Sanada M, Shiraishi Y, Muramatsu H, Kobayashi R, Furukawa K, Miyano S, Kojima S, Ogawa S, Kunishima S. Kitamura K, et al. J Thromb Haemost. 2016 Jul;14(7):1462-9. doi: 10.1111/jth.13350. Epub 2016 Jun 13. J Thromb Haemost. 2016. PMID: 27122003 Free article.
Two groups have recently identified GFI1B as a novel causative gene for congenital macrothrombocytopenia associated with alpha-granule deficiency. Methods We performed whole exome sequencing and identified a novel GFI1B p.G272fsX274 mutation in a family with macrothrombocy …
Two groups have recently identified GFI1B as a novel causative gene for congenital macrothrombocytopenia associated with alpha-granul …
Childhood arterial ischemic stroke: a review of etiologies, antithrombotic treatments, prognostic factors, and priorities for future research.
Lyle CA, Bernard TJ, Goldenberg NA. Lyle CA, et al. Semin Thromb Hemost. 2011 Oct;37(7):786-93. doi: 10.1055/s-0031-1297169. Epub 2011 Dec 20. Semin Thromb Hemost. 2011. PMID: 22187401 Free PMC article. Review.
In recent years, evidence on prognostic factors has accumulated, helping to inform the future design of prognostically stratified RCTs. In this narrative review, we discuss the current understanding of etiologies, consensus-based treatment recommendations, contempor …
In recent years, evidence on prognostic factors has accumulated, helping to inform the future design of prognostically stratif …
23 results