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Quoted phrase not found in phrase index: "Abnormal serum bile acid concentration"
Page 1
Bile acid synthesis, modulation, and dementia: A metabolomic, transcriptomic, and pharmacoepidemiologic study.
Varma VR, Wang Y, An Y, Varma S, Bilgel M, Doshi J, Legido-Quigley C, Delgado JC, Oommen AM, Roberts JA, Wong DF, Davatzikos C, Resnick SM, Troncoso JC, Pletnikova O, O'Brien R, Hak E, Baak BN, Pfeiffer R, Baloni P, Mohmoudiandehkordi S, Nho K, Kaddurah-Daouk R, Bennett DA, Gadalla SM, Thambisetty M. Varma VR, et al. PLoS Med. 2021 May 27;18(5):e1003615. doi: 10.1371/journal.pmed.1003615. eCollection 2021 May. PLoS Med. 2021. PMID: 34043628 Free PMC article.
We tested whether dysregulation of cholesterol catabolism, through its conversion to primary bile acids (BAs), was associated with dementia pathogenesis. METHODS AND FINDINGS: We used a 3-step study design to examine the role of the primary BAs, cholic acid ( …
We tested whether dysregulation of cholesterol catabolism, through its conversion to primary bile acids (BAs), was associated …
Hyocholic acid species as novel biomarkers for metabolic disorders.
Zheng X, Chen T, Zhao A, Ning Z, Kuang J, Wang S, You Y, Bao Y, Ma X, Yu H, Zhou J, Jiang M, Li M, Wang J, Ma X, Zhou S, Li Y, Ge K, Rajani C, Xie G, Hu C, Guo Y, Lu A, Jia W, Jia W. Zheng X, et al. Nat Commun. 2021 Mar 5;12(1):1487. doi: 10.1038/s41467-021-21744-w. Nat Commun. 2021. PMID: 33674561 Free PMC article.
Hyocholic acid (HCA) is a major bile acid (BA) species in the BA pool of pigs, a species known for its exceptional resistance to spontaneous development of diabetic phenotypes. ...We find in the first cohort (n = 1107) that both obesity and diabetes are assoc …
Hyocholic acid (HCA) is a major bile acid (BA) species in the BA pool of pigs, a species known for its exceptional resi …
Primary biliary cirrhosis.
Talwalkar JA, Lindor KD. Talwalkar JA, et al. Lancet. 2003 Jul 5;362(9377):53-61. doi: 10.1016/S0140-6736(03)13808-1. Lancet. 2003. PMID: 12853201 Review.
This disorder is characterised histologically by chronic non-suppurative destruction of interlobular bile ducts leading to advanced fibrosis, cirrhosis, and liver failure. The precise aetiopathogenesis of primary biliary cirrhosis remains unknown, although dysregulation of …
This disorder is characterised histologically by chronic non-suppurative destruction of interlobular bile ducts leading to advanced f …
Elevated bile acids are associated with left ventricular structural changes in biliary atresia.
Virk MK, Mian MUM, Bashir DA, Wilkes JK, Schlingman T, Flores S, Kennedy C, Lam F, Arikan AA, Nguyen T, Mysore K, Galvan NTN, Coss-Bu J, Karpen SJ, Harpavat S, Desai MS. Virk MK, et al. Hepatol Commun. 2023 Apr 14;7(5):e0109. doi: 10.1097/HC9.0000000000000109. eCollection 2023 May 1. Hepatol Commun. 2023. PMID: 37058680 Free PMC article.
RESULTS: In the cohort, 52% (21/40) of children had abnormal LV geometry; the optimal bile acid concentration to detect this abnormality with 70% sensitivity and 64% specificity was 152 mol/L (C-statistics=0.68). Children with bile aci …
RESULTS: In the cohort, 52% (21/40) of children had abnormal LV geometry; the optimal bile acid concentration to …
Bile acids and progesterone metabolites in intrahepatic cholestasis of pregnancy.
Reyes H, Sjövall J. Reyes H, et al. Ann Med. 2000 Mar;32(2):94-106. doi: 10.3109/07853890009011758. Ann Med. 2000. PMID: 10766400 Free article. Review.
Bile acid synthesis appears to be reduced in patients with ICP, in whom primary conjugated bile acids are retained in blood. The major bile acid in blood and urine of these patients is cholic acid instead of chenodeoxycholic aci …
Bile acid synthesis appears to be reduced in patients with ICP, in whom primary conjugated bile acids are retain …
Serum bile acid patterns in neonatal hepatitis and extrahepatic biliary atresia.
Javitt NB, Keating JP, Grand RJ, Harris RC. Javitt NB, et al. J Pediatr. 1977 May;90(5):736-9. doi: 10.1016/s0022-3476(77)81238-9. J Pediatr. 1977. PMID: 856962
Serum bile acid patterns were determined in 31 infants ranging in age from 4 days to 24 weeks. ...The chenodeoxycholate/cholate ratio was greater than one in 13 infants (87%) with atresia and in 10 infants (66%) with neonatal hepatitis. Except for the tendenc …
Serum bile acid patterns were determined in 31 infants ranging in age from 4 days to 24 weeks. ...The chenodeoxycholate …
Inflammatory marker YKL-40 levels in intrahepatic cholestasis of pregnancy.
Temel Yüksel İ, Aslan Çetin B, Köroğlu N, Aydoğan Mathyk B, Erdem B. Temel Yüksel İ, et al. Gynecol Endocrinol. 2019 Jul;35(7):635-637. doi: 10.1080/09513590.2018.1563889. Epub 2019 Jan 27. Gynecol Endocrinol. 2019. PMID: 30688121
Intrahepatic cholestasis of pregnancy is a diagnosis of exclusion and presents with unexplained pruritus, abnormal liver function tests, and increased serum bile acid levels, particularly in the third trimester of pregnancy. ...The cutoff YKL-40 ser …
Intrahepatic cholestasis of pregnancy is a diagnosis of exclusion and presents with unexplained pruritus, abnormal liver function tes …
Fetal cardiac dysfunction in intrahepatic cholestasis of pregnancy is associated with elevated serum bile acid concentrations.
Vasavan T, Deepak S, Jayawardane IA, Lucchini M, Martin C, Geenes V, Yang J, Lövgren-Sandblom A, Seed PT, Chambers J, Stone S, Kurlak L, Dixon PH, Marschall HU, Gorelik J, Chappell L, Loughna P, Thornton J, Pipkin FB, Hayes-Gill B, Fifer WP, Williamson C. Vasavan T, et al. J Hepatol. 2021 May;74(5):1087-1096. doi: 10.1016/j.jhep.2020.11.038. Epub 2020 Dec 1. J Hepatol. 2021. PMID: 33276032 Free PMC article.
There were no significant correlations between maternal or fetal serum bile acid concentrations and fetal HRV parameters or NT-proBNP concentrations in the UDCA-treated cohort. ...HRV values in UDCA-treated cases did not differ from controls. CO …
There were no significant correlations between maternal or fetal serum bile acid concentrations and fetal HRV pa …
Diagnosis, treatment, and clinical outcomes in 43 cases with cerebrotendinous xanthomatosis.
Duell PB, Salen G, Eichler FS, DeBarber AE, Connor SL, Casaday L, Jayadev S, Kisanuki Y, Lekprasert P, Malloy MJ, Ramdhani RA, Ziajka PE, Quinn JF, Su KG, Geller AS, Diffenderfer MR, Schaefer EJ. Duell PB, et al. J Clin Lipidol. 2018 Sep-Oct;12(5):1169-1178. doi: 10.1016/j.jacl.2018.06.008. Epub 2018 Jun 22. J Clin Lipidol. 2018. PMID: 30017468 Free article.
BACKGROUND: Cerebrotendinous xanthomatosis (CTX) is a rare disorder due to defective sterol 27-hydroxylase causing a lack of chenodeoxycholic acid (CDCA) production and high plasma cholestanol levels. OBJECTIVES: Our objective was to review the diagnosis and treatment resu …
BACKGROUND: Cerebrotendinous xanthomatosis (CTX) is a rare disorder due to defective sterol 27-hydroxylase causing a lack of chenodeoxycholi …
Sulphated and unsulphated bile acids in serum, bile, and urine of patients with cholestasis.
van Berge Henegouwen GP, Brandt KH, Eyssen H, Parmentier G. van Berge Henegouwen GP, et al. Gut. 1976 Nov;17(11):861-9. doi: 10.1136/gut.17.11.861. Gut. 1976. PMID: 1001976 Free PMC article.
In cholestasis, the patterns in all three body fluids differed consistently and strikingly. In serum, cholic acid was the major bile acid and most bile acids (greater than 93%) were unsulphated, whereas, in urine, chenodeoxycholic was the …
In cholestasis, the patterns in all three body fluids differed consistently and strikingly. In serum, cholic acid was the majo …
53 results