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Quoted phrase not found in phrase index: "Abnormality of Krebs cycle metabolism"
Page 1
Metabolic features of the cell danger response.
Naviaux RK. Naviaux RK. Mitochondrion. 2014 May;16:7-17. doi: 10.1016/j.mito.2013.08.006. Epub 2013 Aug 24. Mitochondrion. 2014. PMID: 23981537 Free article. Review.
The first wave of danger signals consists of the release of metabolic intermediates like ATP and ADP, Krebs cycle intermediates, oxygen, and reactive oxygen species (ROS), and is sustained by purinergic signaling. After the danger has been eliminated or neutr …
The first wave of danger signals consists of the release of metabolic intermediates like ATP and ADP, Krebs cycle inter …
Diabetes and branched-chain amino acids: What is the link?
Bloomgarden Z. Bloomgarden Z. J Diabetes. 2018 May;10(5):350-352. doi: 10.1111/1753-0407.12645. Epub 2018 Feb 13. J Diabetes. 2018. PMID: 29369529
Similarly, higher BCAA levels track with cardiovascular disease. [Figure: see text] The metabolism of BCAA involves two processes: (i) a reversible process catalysed by a branched-chain aminotransferase (BCAT), either cytosolic or mitochondrial, requiring pyridoxal to func …
Similarly, higher BCAA levels track with cardiovascular disease. [Figure: see text] The metabolism of BCAA involves two processes: (i …
Neuroimaging in mitochondrial disorders.
Mascalchi M, Montomoli M, Guerrini R. Mascalchi M, et al. Essays Biochem. 2018 Jul 20;62(3):409-421. doi: 10.1042/EBC20170109. Print 2018 Jul 20. Essays Biochem. 2018. PMID: 30030366 Review.
However, a normal brain MRI is also possible. (1)HMRS has a diagnostic role in patients with suspected mitochondrial encephalopathy, especially in the acute phase, as it can detect within the lesions, but also in normal appearing nervous tissue or in the ventricular cerebrospinal …
However, a normal brain MRI is also possible. (1)HMRS has a diagnostic role in patients with suspected mitochondrial encephalopathy, especia …
Defects of pyruvate metabolism and the Krebs cycle.
De Meirleir L. De Meirleir L. J Child Neurol. 2002 Dec;17 Suppl 3:3S26-33; discussion 3S33-4. J Child Neurol. 2002. PMID: 12597053 Review.
Seizures and metabolic disease are frequently associated, either indirectly as a consequence of the metabolically caused brain dysgenesis or directly by the metabolic derangement. This article describes defects in pyruvate metabolism (pyruvate carboxyl …
Seizures and metabolic disease are frequently associated, either indirectly as a consequence of the metabolically caused brain …
New insights on the pathogenesis of paraganglioma and pheochromocytoma.
Kantorovich V, Pacak K. Kantorovich V, et al. F1000Res. 2018 Sep 20;7:F1000 Faculty Rev-1500. doi: 10.12688/f1000research.14568.1. eCollection 2018. F1000Res. 2018. PMID: 30345003 Free PMC article. Review.
Establishment of the fact that mutations in multiple components of the PHD-VHL-HIF-2alpha pathway associate with pseudohypoxia-driven tumorigenesis allowed us not only to better understand the effect of this phenomenon but also to more deeply appreciate the value of functional …
Establishment of the fact that mutations in multiple components of the PHD-VHL-HIF-2alpha pathway associate with pseudohypoxia-driven tumori …
Renal cell carcinoma: translational aspects of metabolism and therapeutic consequences.
Yang OC, Maxwell PH, Pollard PJ. Yang OC, et al. Kidney Int. 2013 Oct;84(4):667-81. doi: 10.1038/ki.2013.245. Epub 2013 Jul 3. Kidney Int. 2013. PMID: 23823604 Free article. Review.
These observed genetic aberrations correspond to a diverse range of dysplastic metabolic processes, including mutations in genes encoding tricarboxylic acid (TCA) cycle enzymes, defects in hypoxic and antioxidant signaling, and abnormalities in nutrien …
These observed genetic aberrations correspond to a diverse range of dysplastic metabolic processes, including mutations in genes enco …
Energy metabolism: a new target for gastric cancer treatment.
Liu J, Bai X, Zhang M, Wu S, Xiao J, Zeng X, Li Y, Zhang Z. Liu J, et al. Clin Transl Oncol. 2024 Feb;26(2):338-351. doi: 10.1007/s12094-023-03278-3. Epub 2023 Jul 21. Clin Transl Oncol. 2024. PMID: 37477784 Review.
Various molecules exert their effects by acting on enzymes in the glycolytic pathway, integral to glycolysis. Second, mitochondrial abnormalities in the reprogramming of energy metabolism, with consequences for glutamine metabolism, the tricarboxylic acid …
Various molecules exert their effects by acting on enzymes in the glycolytic pathway, integral to glycolysis. Second, mitochondrial abnor …
Loss of Mitochondrial Ca2+ Uniporter Limits Inotropic Reserve and Provides Trigger and Substrate for Arrhythmias in Barth Syndrome Cardiomyopathy.
Bertero E, Nickel A, Kohlhaas M, Hohl M, Sequeira V, Brune C, Schwemmlein J, Abeßer M, Schuh K, Kutschka I, Carlein C, Münker K, Atighetchi S, Müller A, Kazakov A, Kappl R, von der Malsburg K, van der Laan M, Schiuma AF, Böhm M, Laufs U, Hoth M, Rehling P, Kuhn M, Dudek J, von der Malsburg A, Prates Roma L, Maack C. Bertero E, et al. Circulation. 2021 Nov 23;144(21):1694-1713. doi: 10.1161/CIRCULATIONAHA.121.053755. Epub 2021 Oct 14. Circulation. 2021. PMID: 34648376 Free article.
Taz deficiency provoked heart-specific loss of mitochondrial Ca(2+) uniporter protein that prevented Ca(2+)-induced activation of the Krebs cycle during beta-adrenergic stimulation, oxidizing pyridine nucleotides and triggering arrhythmias in cardiac myocytes. ...
Taz deficiency provoked heart-specific loss of mitochondrial Ca(2+) uniporter protein that prevented Ca(2+)-induced activation of the Kre …
Pathophysiology and molecular basis of selected metabolic abnormalities in Huntington's disease.
Krzysztoń-Russjan J. Krzysztoń-Russjan J. Postepy Hig Med Dosw (Online). 2016 Dec 30;70(0):1331-1342. doi: 10.5604/17322693.1227557. Postepy Hig Med Dosw (Online). 2016. PMID: 28100843 Free article. Review.
Impairment of energy processes demonstrated by a decrease of ATP production and increase of oxidative stress markers was determined in- and outside of the CNS in glycolysis, the Krebs cycle and the electron transport chain. A correlation between the increase of ener …
Impairment of energy processes demonstrated by a decrease of ATP production and increase of oxidative stress markers was determined in- and …
Recent Advances in Histopathological and Molecular Diagnosis in Pheochromocytoma and Paraganglioma: Challenges for Predicting Metastasis in Individual Patients.
Yamazaki Y, Gao X, Pecori A, Nakamura Y, Tezuka Y, Omata K, Ono Y, Morimoto R, Satoh F, Sasano H. Yamazaki Y, et al. Front Endocrinol (Lausanne). 2020 Oct 27;11:587769. doi: 10.3389/fendo.2020.587769. eCollection 2020. Front Endocrinol (Lausanne). 2020. PMID: 33193100 Free PMC article. Review.
More than 30%-40% of PHEO/PGL are reported to be associated with hereditary genetic abnormalities involving > 20 genes, including SDHXs, RET, VHL, NF1, TMEM127, MAX, and others. ...In addition, therapeutic strategies specifically targeting such genetic abnormalities …
More than 30%-40% of PHEO/PGL are reported to be associated with hereditary genetic abnormalities involving > 20 genes, including …
66 results