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2004 5
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106 results

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Quoted phrase not found in phrase index: "Abnormality of redox activity"
Page 1
Expert consensus document: Mitochondrial function as a therapeutic target in heart failure.
Brown DA, Perry JB, Allen ME, Sabbah HN, Stauffer BL, Shaikh SR, Cleland JG, Colucci WS, Butler J, Voors AA, Anker SD, Pitt B, Pieske B, Filippatos G, Greene SJ, Gheorghiade M. Brown DA, et al. Nat Rev Cardiol. 2017 Apr;14(4):238-250. doi: 10.1038/nrcardio.2016.203. Epub 2016 Dec 22. Nat Rev Cardiol. 2017. PMID: 28004807 Free PMC article. Review.
Despite all the available therapies, the condition carries a very poor prognosis. Existing therapies provide symptomatic and clinical benefit, but do not fully address molecular abnormalities that occur in cardiomyocytes. ...Although the pathophysiology of heart fai …
Despite all the available therapies, the condition carries a very poor prognosis. Existing therapies provide symptomatic and clinical …
Targeting IGF1R signaling enhances the sensitivity of cisplatin by inhibiting proline and arginine metabolism in oesophageal squamous cell carcinoma under hypoxia.
Fang K, Sun M, Leng Z, Chu Y, Zhao Z, Li Z, Zhang Y, Xu A, Zhang Z, Zhang L, Chen T, Xu M. Fang K, et al. J Exp Clin Cancer Res. 2023 Mar 28;42(1):73. doi: 10.1186/s13046-023-02623-2. J Exp Clin Cancer Res. 2023. PMID: 36978187 Free PMC article.
Since oxygen-deprivation frequently lead to metabolic reprogramming, we further learned via metabolomics analysis that abnormal IGF1R pathways promoted the expression of metabolic enzymes ASS1 and PYCR1 by the transcriptional activity of c-MYC. In detail, enhanced e …
Since oxygen-deprivation frequently lead to metabolic reprogramming, we further learned via metabolomics analysis that abnormal IGF1R …
Vitamin neurotoxicity.
Snodgrass SR. Snodgrass SR. Mol Neurobiol. 1992 Spring;6(1):41-73. doi: 10.1007/BF02935566. Mol Neurobiol. 1992. PMID: 1463588 Review.
Vitamin D3 effects on central nervous system (CNS) gene expression are predictable, in addition to the indirect effects owing to its influence on calcium and phosphorus homeostasis. ...Because vitamin A and analogs enter the CNS better than most vitamins, and because retin …
Vitamin D3 effects on central nervous system (CNS) gene expression are predictable, in addition to the indirect effects owing to its …
Cyclin D-CDK4 Disulfide Bond Attenuates Pulmonary Vascular Cell Proliferation.
Knight H, Abis G, Kaur M, Green HLH, Krasemann S, Hartmann K, Lynham S, Clark J, Zhao L, Ruppert C, Weiss A, Schermuly RT, Eaton P, Rudyk O. Knight H, et al. Circ Res. 2023 Dec 8;133(12):966-988. doi: 10.1161/CIRCRESAHA.122.321836. Epub 2023 Nov 13. Circ Res. 2023. PMID: 37955182 Free PMC article.
BACKGROUND: Pulmonary hypertension (PH) is a chronic vascular disease characterized, among other abnormalities, by hyperproliferative smooth muscle cells and a perturbed cellular redox and metabolic balance. ...CONCLUSIONS: A novel disulfide bond in cyclin D-CDK4 ac …
BACKGROUND: Pulmonary hypertension (PH) is a chronic vascular disease characterized, among other abnormalities, by hyperproliferative …
Unravelling the role of NFE2L1 in stress responses and related diseases.
Liu X, Xu C, Xiao W, Yan N. Liu X, et al. Redox Biol. 2023 Sep;65:102819. doi: 10.1016/j.redox.2023.102819. Epub 2023 Jul 14. Redox Biol. 2023. PMID: 37473701 Free PMC article. Review.
The nuclear factor erythroid 2 (NF-E2)-related factor 1 (NFE2L1, also known as Nrf1) is a highly conserved transcription factor that belongs to the CNC-bZIP subfamily. Its significance lies in its control over redox balance, proteasome activity, and organ integrity. …
The nuclear factor erythroid 2 (NF-E2)-related factor 1 (NFE2L1, also known as Nrf1) is a highly conserved transcription factor that belongs …
Importance of oxidative stress in the pathogenesis, diagnosis, and monitoring of patients with neuropsychiatric disorders, a review.
Cecerska-Heryć E, Polikowska A, Serwin N, Roszak M, Grygorcewicz B, Heryć R, Michalczyk A, Dołęgowska B. Cecerska-Heryć E, et al. Neurochem Int. 2022 Feb;153:105269. doi: 10.1016/j.neuint.2021.105269. Epub 2021 Dec 29. Neurochem Int. 2022. PMID: 34971747 Review.
All conditions show increased lipid peroxidation, which appears to be typical of psychiatric disorders because the brain contains large amounts of these types of molecules. In addition, numerous abnormalities in the antioxidant defense are noted, but the results of studies …
All conditions show increased lipid peroxidation, which appears to be typical of psychiatric disorders because the brain contains large amou …
The Tryptophan Pathway Targeting Antioxidant Capacity in the Placenta.
Xu K, Liu G, Fu C. Xu K, et al. Oxid Med Cell Longev. 2018 Jul 22;2018:1054797. doi: 10.1155/2018/1054797. eCollection 2018. Oxid Med Cell Longev. 2018. PMID: 30140360 Free PMC article. Review.
Dysfunction of the placenta can be caused by oxidative stress and can lead to abnormal fetal development. Preventing oxidative stress of the placenta is thus an important measure to ensure positive birth outcomes. ...In this review, we summarize research on the antioxidant …
Dysfunction of the placenta can be caused by oxidative stress and can lead to abnormal fetal development. Preventing oxidative stress …
Targeting Histone Deacetylases in Diseases: Where Are We?
Benedetti R, Conte M, Altucci L. Benedetti R, et al. Antioxid Redox Signal. 2015 Jul 1;23(1):99-126. doi: 10.1089/ars.2013.5776. Epub 2014 Mar 6. Antioxid Redox Signal. 2015. PMID: 24382114 Free PMC article. Review.
Histone acetylation balance obtained through opposing actions of histone deacetylases (HDACs) and histone acetyltransferases is one epigenetic mechanism controlling gene expression and is, thus, associated with disease etiology and progression. Interfering pharmacologically with …
Histone acetylation balance obtained through opposing actions of histone deacetylases (HDACs) and histone acetyltransferases is one epigenet …
Impaired mitochondrial quality control in Rett Syndrome.
Crivellari I, Pecorelli A, Cordone V, Marchi S, Pinton P, Hayek J, Cervellati C, Valacchi G. Crivellari I, et al. Arch Biochem Biophys. 2021 Mar 30;700:108790. doi: 10.1016/j.abb.2021.108790. Epub 2021 Feb 4. Arch Biochem Biophys. 2021. PMID: 33549528
While the genetic basis of RTT is known, the exact pathogenic mechanisms that lead to the broad spectrum of symptoms still remain enigmatic. Alterations in the redox homeostasis have been proposed among the contributing factors to the development and progression of the syn …
While the genetic basis of RTT is known, the exact pathogenic mechanisms that lead to the broad spectrum of symptoms still remain enigmatic. …
Magnetic Resonance Spectroscopy Studies of Brain Energy Metabolism in Schizophrenia: Progression from Prodrome to Chronic Psychosis.
Stein A, Zhu C, Du F, Öngür D. Stein A, et al. Curr Psychiatry Rep. 2023 Nov;25(11):659-669. doi: 10.1007/s11920-023-01457-1. Epub 2023 Oct 9. Curr Psychiatry Rep. 2023. PMID: 37812338 Review.
Our review covers research related to high-energy phosphate metabolism, lactate, intracellular pH, redox ratio, and the antioxidant glutathione. RECENT FINDINGS: Both first-episode and chronic SZ patients display a significant reduction in creatine kinase reaction activ …
Our review covers research related to high-energy phosphate metabolism, lactate, intracellular pH, redox ratio, and the antioxidant g …
106 results