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269 results

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Quoted phrase not found in phrase index: "Abnormality of redox activity"
Page 1
Oxidative stress and diabetic retinopathy: Molecular mechanisms, pathogenetic role and therapeutic implications.
Kang Q, Yang C. Kang Q, et al. Redox Biol. 2020 Oct;37:101799. doi: 10.1016/j.redox.2020.101799. Epub 2020 Nov 13. Redox Biol. 2020. PMID: 33248932 Free PMC article. Review.
Oxidative stress can both contribute to and result from the metabolic abnormalities induced by hyperglycemia, mainly including the increased flux of the polyol pathway and hexosamine pathway, the hyper-activation of protein kinase C (PKC) isoforms, and the accumulat …
Oxidative stress can both contribute to and result from the metabolic abnormalities induced by hyperglycemia, mainly including the in …
Ferroptosis Promotes Cyst Growth in Autosomal Dominant Polycystic Kidney Disease Mouse Models.
Zhang X, Li LX, Ding H, Torres VE, Yu C, Li X. Zhang X, et al. J Am Soc Nephrol. 2021 Nov;32(11):2759-2776. doi: 10.1681/ASN.2021040460. J Am Soc Nephrol. 2021. PMID: 34716241 Free PMC article.
The abnormalities also include increased expression of iron importers (TfR1, DMT1) and HO-1, which in turn result in high iron levels, low GSH and GPX4 activity, increased lipid peroxidation, and propensity to ferroptosis. ...A lipid peroxidation product increased i …
The abnormalities also include increased expression of iron importers (TfR1, DMT1) and HO-1, which in turn result in high iron levels …
Excessive oxidative stress in cumulus granulosa cells induced cell senescence contributes to endometriosis-associated infertility.
Lin X, Dai Y, Tong X, Xu W, Huang Q, Jin X, Li C, Zhou F, Zhou H, Lin X, Huang D, Zhang S. Lin X, et al. Redox Biol. 2020 Feb;30:101431. doi: 10.1016/j.redox.2020.101431. Epub 2020 Jan 12. Redox Biol. 2020. PMID: 31972508 Free PMC article.
We aimed to illuminate the etiopathogenesis of endometriosis-associated infertility that involve excessive oxidative stress (OS) induced pathological changes of ovary cumulus granulosa cell (GCs). Senescence-associated beta-galactosidase (SA beta-gal) activity in GCs from …
We aimed to illuminate the etiopathogenesis of endometriosis-associated infertility that involve excessive oxidative stress (OS) induced pat …
Multifunctional Liposomes.
Aryasomayajula B, Salzano G, Torchilin VP. Aryasomayajula B, et al. Methods Mol Biol. 2017;1530:41-61. doi: 10.1007/978-1-4939-6646-2_3. Methods Mol Biol. 2017. PMID: 28150195
Compared to conventional liposomes, stimuli-sensitive nanoplatforms respond to local conditions that are characteristics of the pathological area of interest, allowing the release of active agents at the targeted site. Acidic pH, abnormal levels of enzymes, temperat …
Compared to conventional liposomes, stimuli-sensitive nanoplatforms respond to local conditions that are characteristics of the pathological …
Redox active metals in neurodegenerative diseases.
Acevedo K, Masaldan S, Opazo CM, Bush AI. Acevedo K, et al. J Biol Inorg Chem. 2019 Dec;24(8):1141-1157. doi: 10.1007/s00775-019-01731-9. Epub 2019 Oct 24. J Biol Inorg Chem. 2019. PMID: 31650248 Review.
Copper (Cu) and iron (Fe) are redox active metals essential for the regulation of cellular pathways that are fundamental for brain function, including neurotransmitter synthesis and release, neurotransmission, and protein turnover. ...Here we review the evidence tha …
Copper (Cu) and iron (Fe) are redox active metals essential for the regulation of cellular pathways that are fundamental for b …
The NAD(+) precursor nicotinamide riboside enhances oxidative metabolism and protects against high-fat diet-induced obesity.
Cantó C, Houtkooper RH, Pirinen E, Youn DY, Oosterveer MH, Cen Y, Fernandez-Marcos PJ, Yamamoto H, Andreux PA, Cettour-Rose P, Gademann K, Rinsch C, Schoonjans K, Sauve AA, Auwerx J. Cantó C, et al. Cell Metab. 2012 Jun 6;15(6):838-47. doi: 10.1016/j.cmet.2012.04.022. Cell Metab. 2012. PMID: 22682224 Free PMC article.
As NAD(+) is a rate-limiting cosubstrate for the sirtuin enzymes, its modulation is emerging as a valuable tool to regulate sirtuin function and, consequently, oxidative metabolism. In line with this premise, decreased activity of PARP-1 or CD38-both NAD(+) consumers-incre …
As NAD(+) is a rate-limiting cosubstrate for the sirtuin enzymes, its modulation is emerging as a valuable tool to regulate sirtuin function …
Melatonin and Respiratory Diseases: A Review.
Habtemariam S, Daglia M, Sureda A, Selamoglu Z, Gulhan MF, Nabavi SM. Habtemariam S, et al. Curr Top Med Chem. 2017;17(4):467-488. doi: 10.2174/1568026616666160824120338. Curr Top Med Chem. 2017. PMID: 27558675 Review.
Melatonin is an indoleamine with potent multifunctional biological and pharmacological effects, both receptor dependent and receptor-independent effects, including antioxidant, anticancer, antitumor, anti-inflammatory, anti-aging, anti-diabetic, antiviral, neuroprotective acti …
Melatonin is an indoleamine with potent multifunctional biological and pharmacological effects, both receptor dependent and receptor-indepen …
Targeting IGF1R signaling enhances the sensitivity of cisplatin by inhibiting proline and arginine metabolism in oesophageal squamous cell carcinoma under hypoxia.
Fang K, Sun M, Leng Z, Chu Y, Zhao Z, Li Z, Zhang Y, Xu A, Zhang Z, Zhang L, Chen T, Xu M. Fang K, et al. J Exp Clin Cancer Res. 2023 Mar 28;42(1):73. doi: 10.1186/s13046-023-02623-2. J Exp Clin Cancer Res. 2023. PMID: 36978187 Free PMC article.
Since oxygen-deprivation frequently lead to metabolic reprogramming, we further learned via metabolomics analysis that abnormal IGF1R pathways promoted the expression of metabolic enzymes ASS1 and PYCR1 by the transcriptional activity of c-MYC. In detail, enhanced e …
Since oxygen-deprivation frequently lead to metabolic reprogramming, we further learned via metabolomics analysis that abnormal IGF1R …
Vitamin neurotoxicity.
Snodgrass SR. Snodgrass SR. Mol Neurobiol. 1992 Spring;6(1):41-73. doi: 10.1007/BF02935566. Mol Neurobiol. 1992. PMID: 1463588 Review.
Because vitamin A and analogs enter the CNS better than most vitamins, and because retinoids have many effects on enzyme activity and gene expression, Vitamin A neurotoxicity is more likely than that of most, perhaps all other vitamins. ...
Because vitamin A and analogs enter the CNS better than most vitamins, and because retinoids have many effects on enzyme activity and …
Phytochemical activators of Nrf2: a review of therapeutic strategies in diabetes.
Qin S, Chen Z, Wen Y, Yi Y, Lv C, Zeng C, Chen L, Shi M. Qin S, et al. Acta Biochim Biophys Sin (Shanghai). 2022 Dec 25;55(1):11-22. doi: 10.3724/abbs.2022192. Acta Biochim Biophys Sin (Shanghai). 2022. PMID: 36647719 Free PMC article. Review.
Insulin resistance (IR) is fundamental to the development of type 2 diabetes (T2D), and altered mitochondrial function and abnormal lipid distribution are closely associated with IR or T2D. Excess oxidative stress-induced mitochondrial damage leads to an imbalance in re …
Insulin resistance (IR) is fundamental to the development of type 2 diabetes (T2D), and altered mitochondrial function and abnormal l …
269 results