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Quoted phrase not found in phrase index: "Abnormality of the alternative complement pathway"
Page 1
Complement dysregulation in glomerulonephritis.
Kaartinen K, Safa A, Kotha S, Ratti G, Meri S. Kaartinen K, et al. Semin Immunol. 2019 Oct;45:101331. doi: 10.1016/j.smim.2019.101331. Epub 2019 Nov 9. Semin Immunol. 2019. PMID: 31711769 Free article. Review.
A large proportion of the disease manifestations are caused by disturbances in the complement system. They can be due to genetic errors, autoimmunity, microbes or abnormal immunoglobulins, like modified IgA or paraproteins. The common denominator in most of the prob …
A large proportion of the disease manifestations are caused by disturbances in the complement system. They can be due to genetic erro …
A Narrative Review on C3 Glomerulopathy: A Rare Renal Disease.
Schena FP, Esposito P, Rossini M. Schena FP, et al. Int J Mol Sci. 2020 Jan 14;21(2):525. doi: 10.3390/ijms21020525. Int J Mol Sci. 2020. PMID: 31947692 Free PMC article. Review.
The persistent presence of microhematuria with or without light or heavy proteinuria after an infection episode suggests the potential onset of C3 GP. These nephritides are characterized by abnormal activation of the complement alternative pathway, …
The persistent presence of microhematuria with or without light or heavy proteinuria after an infection episode suggests the potential onset …
Update on C3 Glomerulopathy: A Complement-Mediated Disease.
Caravaca-Fontán F, Lucientes L, Cavero T, Praga M. Caravaca-Fontán F, et al. Nephron. 2020;144(6):272-280. doi: 10.1159/000507254. Epub 2020 May 5. Nephron. 2020. PMID: 32369815 Free article. Review.
C3 glomerulopathy (C3G) is a clinicopathologic entity secondary to dysregulation of the alternative complement pathway in plasma and the glomerular microenvironment. ...Thus, a new pathogenic classification based on a cluster analysis of clinical, histologic, …
C3 glomerulopathy (C3G) is a clinicopathologic entity secondary to dysregulation of the alternative complement pathway …
Retinal findings in glomerulonephritis.
Mack HG, Colville DJ, Harraka P, Savige JA, Invernizzi A, Fraser-Bell S. Mack HG, et al. Clin Exp Optom. 2022 Jul;105(5):474-486. doi: 10.1080/08164622.2021.2003691. Epub 2021 Dec 8. Clin Exp Optom. 2022. PMID: 34877922 Review.
The complement system is part of the innate immune system activated by three distinct pathways: classical, lectin and alternative. ...Dense deposit disease is a rare renal disease associated with mutations in Complement factor H and overactivity of the alt …
The complement system is part of the innate immune system activated by three distinct pathways: classical, lectin and alternative …
C3 glomerulopathy.
Servais A, Noël LH, Frémeaux-Bacchi V, Lesavre P. Servais A, et al. Contrib Nephrol. 2013;181:185-93. doi: 10.1159/000348654. Epub 2013 May 8. Contrib Nephrol. 2013. PMID: 23689580 Review.
The most common histological feature in these diseases is the presence of glomerular deposition of C3 within the mesangium and along the glomerular basement membrane (GBM) in the subendothelial area or within the GBM. The key role of complement alternative pathwa …
The most common histological feature in these diseases is the presence of glomerular deposition of C3 within the mesangium and along the glo …
Pregnancy-associated hemolytic uremic syndrome.
Alobaidi S, AlDabbagh A, Alamoudi A, Almowarey M, Akl A. Alobaidi S, et al. Saudi J Kidney Dis Transpl. 2020 Nov-Dec;31(6):1180-1188. doi: 10.4103/1319-2442.308326. Saudi J Kidney Dis Transpl. 2020. PMID: 33565429 Review.
Its mechanism of action is related mainly to the disturbance in the activation of the complement alternative pathway, leading to damage of the microvascular endothelium. ...The absence of causative genetic mutations does not always exclude a diagnosis of aHUS …
Its mechanism of action is related mainly to the disturbance in the activation of the complement alternative pathway, l …
The role of the alternative pathway of complement activation in glomerular diseases.
Łukawska E, Polcyn-Adamczak M, Niemir ZI. Łukawska E, et al. Clin Exp Med. 2018 Aug;18(3):297-318. doi: 10.1007/s10238-018-0491-8. Epub 2018 Feb 15. Clin Exp Med. 2018. PMID: 29450785 Review.
Out of three known pathways of complement activation, the alternative pathway (AP) plays a critical role in host defense by amplifying the complement response, independently of initiation pathway and continuously maintaining low-level activity i …
Out of three known pathways of complement activation, the alternative pathway (AP) plays a critical role in host defens …
C3 Glomerulopathy and Related Disorders in Children: Etiology-Phenotype Correlation and Outcomes.
Wong EKS, Marchbank KJ, Lomax-Browne H, Pappworth IY, Denton H, Cooke K, Ward S, McLoughlin AC, Richardson G, Wilson V, Harris CL, Morgan BP, Hakobyan S, McAlinden P, Gale DP, Maxwell H, Christian M, Malcomson R, Goodship THJ, Marks SD, Pickering MC, Kavanagh D, Cook HT, Johnson SA; MPGN/DDD/C3 Glomerulopathy Rare Disease Group and National Study of MPGN/DDD/C3 Glomerulopathy Investigators. Wong EKS, et al. Clin J Am Soc Nephrol. 2021 Nov;16(11):1639-1651. doi: 10.2215/CJN.00320121. Epub 2021 Sep 22. Clin J Am Soc Nephrol. 2021. PMID: 34551983 Free PMC article.
BACKGROUND AND OBJECTIVES: Membranoproliferative GN and C3 glomerulopathy are rare and overlapping disorders associated with dysregulation of the alternative complement pathway. Specific etiologic data for pediatric membranoproliferative GN/C3 glomerulopathy …
BACKGROUND AND OBJECTIVES: Membranoproliferative GN and C3 glomerulopathy are rare and overlapping disorders associated with dysregulation o …
An overview of lipodystrophy and the role of the complement system.
Corvillo F, Akinci B. Corvillo F, et al. Mol Immunol. 2019 Aug;112:223-232. doi: 10.1016/j.molimm.2019.05.011. Epub 2019 Jun 6. Mol Immunol. 2019. PMID: 31177059 Review.
Another heterogeneous group of ultra-rare diseases in which complement abnormalities have been described are the lipodystrophy syndromes. ...Even so, the mechanism through which the complement system induces adipose tissue abnormalities remains unclear …
Another heterogeneous group of ultra-rare diseases in which complement abnormalities have been described are the lipodystrophy …
Autoimmune abnormalities of the alternative complement pathway in membranoproliferative glomerulonephritis and C3 glomerulopathy.
Noris M, Donadelli R, Remuzzi G. Noris M, et al. Pediatr Nephrol. 2019 Aug;34(8):1311-1323. doi: 10.1007/s00467-018-3989-0. Epub 2018 Jun 9. Pediatr Nephrol. 2019. PMID: 29948306 Review.
Genetic and autoimmune abnormalities causing hyperactivation of the complement alternative pathway have been found as frequently in patients with immune complex-associated MPGN (IC-MPGN) as in those with C3G. ...A few patients, mainly with IC-MPGN, car …
Genetic and autoimmune abnormalities causing hyperactivation of the complement alternative pathway have been fou …
131 results