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Quoted phrase not found in phrase index: "Abnormality of the alternative complement pathway"
Page 1
A Review of Complement Activation in SLE.
Weinstein A, Alexander RV, Zack DJ. Weinstein A, et al. Curr Rheumatol Rep. 2021 Feb 10;23(3):16. doi: 10.1007/s11926-021-00984-1. Curr Rheumatol Rep. 2021. PMID: 33569681 Free PMC article. Review.
This review is aimed at comparing the usefulness of measurement of complement proteins in serum/plasma (C3, C4) to complement activation (split) products in plasma and on circulating blood cells for SLE diagnosis, disease monitoring, and prognosis. ...C4d als …
This review is aimed at comparing the usefulness of measurement of complement proteins in serum/plasma (C3, C4) to complement …
Complement dysregulation in glomerulonephritis.
Kaartinen K, Safa A, Kotha S, Ratti G, Meri S. Kaartinen K, et al. Semin Immunol. 2019 Oct;45:101331. doi: 10.1016/j.smim.2019.101331. Epub 2019 Nov 9. Semin Immunol. 2019. PMID: 31711769 Free article. Review.
A large proportion of the disease manifestations are caused by disturbances in the complement system. They can be due to genetic errors, autoimmunity, microbes or abnormal immunoglobulins, like modified IgA or paraproteins. The common denominator in most of the prob …
A large proportion of the disease manifestations are caused by disturbances in the complement system. They can be due to genetic erro …
Pathogenesis of Atypical Hemolytic Uremic Syndrome.
Yoshida Y, Kato H, Ikeda Y, Nangaku M. Yoshida Y, et al. J Atheroscler Thromb. 2019 Feb 1;26(2):99-110. doi: 10.5551/jat.RV17026. Epub 2018 Nov 2. J Atheroscler Thromb. 2019. PMID: 30393246 Free PMC article. Review.
Atypical hemolytic uremic syndrome (aHUS) is a type of thrombotic microangiopathy (TMA) defined by thrombocytopenia, microangiopathic hemolytic anemia, and renal failure. aHUS is caused by uncontrolled complement activation in the alternative pathway (AP). A …
Atypical hemolytic uremic syndrome (aHUS) is a type of thrombotic microangiopathy (TMA) defined by thrombocytopenia, microangiopathic hemoly …
C3G and Ig-MPGN-treatment standard.
Noris M, Remuzzi G. Noris M, et al. Nephrol Dial Transplant. 2024 Jan 31;39(2):202-214. doi: 10.1093/ndt/gfad182. Nephrol Dial Transplant. 2024. PMID: 37604793 Free PMC article. Review.
Primary C3G and Ig-MPGN share the same prevalence of low serum C3 levels and of abnormalities of the alternative pathway of complement, and patients who present a bioptic pattern of Ig-MPGN at onset may show a C3G pattern in a subsequent biopsy. ...We …
Primary C3G and Ig-MPGN share the same prevalence of low serum C3 levels and of abnormalities of the alternative pathway …
Update on C3 Glomerulopathy: A Complement-Mediated Disease.
Caravaca-Fontán F, Lucientes L, Cavero T, Praga M. Caravaca-Fontán F, et al. Nephron. 2020;144(6):272-280. doi: 10.1159/000507254. Epub 2020 May 5. Nephron. 2020. PMID: 32369815 Free article. Review.
C3 glomerulopathy (C3G) is a clinicopathologic entity secondary to dysregulation of the alternative complement pathway in plasma and the glomerular microenvironment. ...Thus, a new pathogenic classification based on a cluster analysis of clinical, histologic, …
C3 glomerulopathy (C3G) is a clinicopathologic entity secondary to dysregulation of the alternative complement pathway …
Complement activation is a crucial driver of acute kidney injury in rhabdomyolysis.
Boudhabhay I, Poillerat V, Grunenwald A, Torset C, Leon J, Daugan MV, Lucibello F, El Karoui K, Ydee A, Chauvet S, Girardie P, Sacks S, Farrar CA, Garred P, Berthaud R, Le Quintrec M, Rabant M, de Lonlay P, Rambaud C, Gnemmi V, Fremeaux-Bacchi V, Frimat M, Roumenina LT. Boudhabhay I, et al. Kidney Int. 2021 Mar;99(3):581-597. doi: 10.1016/j.kint.2020.09.033. Epub 2020 Nov 1. Kidney Int. 2021. PMID: 33137339 Free article.
Concomitantly, myoglobin-derived heme activated the alternative pathway. Complement deposition and acute kidney injury were attenuated by pre-treatment with the heme scavenger hemopexin. This indicates that complement was activated in a unique double-t …
Concomitantly, myoglobin-derived heme activated the alternative pathway. Complement deposition and acute kidney injury …
C3 glomerulopathy and current dilemmas.
Ito N, Ohashi R, Nagata M. Ito N, et al. Clin Exp Nephrol. 2017 Aug;21(4):541-551. doi: 10.1007/s10157-016-1358-5. Epub 2016 Nov 23. Clin Exp Nephrol. 2017. PMID: 27878657 Free PMC article. Review.
Recent molecular and genetic advances provide information to characterize C3G. Some C3G cases are found with genetic abnormalities in complement regulatory factors, but majority of cases seem to be associated with acquired factors that dysregulate the alternative …
Recent molecular and genetic advances provide information to characterize C3G. Some C3G cases are found with genetic abnormalities in …
C3 Glomerulopathy and Related Disorders in Children: Etiology-Phenotype Correlation and Outcomes.
Wong EKS, Marchbank KJ, Lomax-Browne H, Pappworth IY, Denton H, Cooke K, Ward S, McLoughlin AC, Richardson G, Wilson V, Harris CL, Morgan BP, Hakobyan S, McAlinden P, Gale DP, Maxwell H, Christian M, Malcomson R, Goodship THJ, Marks SD, Pickering MC, Kavanagh D, Cook HT, Johnson SA; MPGN/DDD/C3 Glomerulopathy Rare Disease Group and National Study of MPGN/DDD/C3 Glomerulopathy Investigators. Wong EKS, et al. Clin J Am Soc Nephrol. 2021 Nov;16(11):1639-1651. doi: 10.2215/CJN.00320121. Epub 2021 Sep 22. Clin J Am Soc Nephrol. 2021. PMID: 34551983 Free PMC article.
BACKGROUND AND OBJECTIVES: Membranoproliferative GN and C3 glomerulopathy are rare and overlapping disorders associated with dysregulation of the alternative complement pathway. Specific etiologic data for pediatric membranoproliferative GN/C3 glomerulopathy …
BACKGROUND AND OBJECTIVES: Membranoproliferative GN and C3 glomerulopathy are rare and overlapping disorders associated with dysregulation o …
Atypical hemolytic uremic syndrome.
Loirat C, Frémeaux-Bacchi V. Loirat C, et al. Orphanet J Rare Dis. 2011 Sep 8;6:60. doi: 10.1186/1750-1172-6-60. Orphanet J Rare Dis. 2011. PMID: 21902819 Free PMC article. Review.
Atypical HUS (aHUS) defines non Shiga-toxin-HUS and even if some authors include secondary aHUS due to Streptococcus pneumoniae or other causes, aHUS designates a primary disease due to a disorder in complement alternative pathway regulation. Atypical HUS rep …
Atypical HUS (aHUS) defines non Shiga-toxin-HUS and even if some authors include secondary aHUS due to Streptococcus pneumoniae or other cau …
Extra-renal manifestations of atypical hemolytic uremic syndrome.
Formeck C, Swiatecka-Urban A. Formeck C, et al. Pediatr Nephrol. 2019 Aug;34(8):1337-1348. doi: 10.1007/s00467-018-4039-7. Epub 2018 Aug 14. Pediatr Nephrol. 2019. PMID: 30109445 Free PMC article. Review.
Atypical hemolytic uremic syndrome (aHUS) is a rare and complex disease resulting from abnormal alternative complement activation with a wide range of clinical presentations. ...While some of these extra-renal manifestations occur in the acute phase of aHUS, …
Atypical hemolytic uremic syndrome (aHUS) is a rare and complex disease resulting from abnormal alternative complement …
55 results