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1982 1
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163 results

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Quoted phrase not found in phrase index: "Absence of peroxisomes"
Page 1
Diabetic Cardiomyopathy: An Update of Mechanisms Contributing to This Clinical Entity.
Jia G, Hill MA, Sowers JR. Jia G, et al. Circ Res. 2018 Feb 16;122(4):624-638. doi: 10.1161/CIRCRESAHA.117.311586. Circ Res. 2018. PMID: 29449364 Free PMC article. Review.
In people with diabetes mellitus, the presence of myocardial dysfunction in the absence of overt clinical coronary artery disease, valvular disease, and other conventional cardiovascular risk factors, such as hypertension and dyslipidemia, has led to the descriptive termin …
In people with diabetes mellitus, the presence of myocardial dysfunction in the absence of overt clinical coronary artery disease, va …
Fibrosis in fat: From other diseases to Crohn's disease.
Xiong S, Tan J, Wang Y, He J, Hu F, Wu X, Liu Z, Lin S, Li X, Chen Z, Mao R. Xiong S, et al. Front Immunol. 2022 Aug 25;13:935275. doi: 10.3389/fimmu.2022.935275. eCollection 2022. Front Immunol. 2022. PMID: 36091035 Free PMC article. Review.
More specifically, we illustrated the role of various cells (adipocyte progenitors, macrophages, mast cells, and group 1 innate lymphoid cells) and molecules (including hypoxia-inducible factor 1-alpha, transforming growth factor-beta, platelet-derived growth factor, and perox …
More specifically, we illustrated the role of various cells (adipocyte progenitors, macrophages, mast cells, and group 1 innate lymphoid cel …
Evolution of peroxisomes illustrates symbiogenesis.
Speijer D. Speijer D. Bioessays. 2017 Sep;39(9). doi: 10.1002/bies.201700050. Epub 2017 Aug 7. Bioessays. 2017. PMID: 28782202 Review.
Recently, the group of McBride reported a stunning observation regarding peroxisome biogenesis: newly born peroxisomes are hybrids of mitochondrial and ER-derived pre-peroxisomes. ...Studies performed with the yeast Saccharomyces cerevisiae had convincingly s …
Recently, the group of McBride reported a stunning observation regarding peroxisome biogenesis: newly born peroxisomes are hyb …
Evolution of adrenoleukodystrophy model systems.
Montoro R, Heine VM, Kemp S, Engelen M. Montoro R, et al. J Inherit Metab Dis. 2021 May;44(3):544-553. doi: 10.1002/jimd.12357. Epub 2021 Jan 7. J Inherit Metab Dis. 2021. PMID: 33373044 Free PMC article. Review.
The disease is caused by mutations in the ABCD1 gene resulting in a defect in peroxisomal degradation of very long-chain fatty acids and their accumulation in plasma and tissues. ...In adulthood, 80% of women with ALD also develop myelopathy, but adrenal insufficiency or c …
The disease is caused by mutations in the ABCD1 gene resulting in a defect in peroxisomal degradation of very long-chain fatty acids …
Lysosome-Dependent LXR and PPARδ Activation Upon Efferocytosis in Human Macrophages.
Mota AC, Dominguez M, Weigert A, Snodgrass RG, Namgaladze D, Brüne B. Mota AC, et al. Front Immunol. 2021 May 7;12:637778. doi: 10.3389/fimmu.2021.637778. eCollection 2021. Front Immunol. 2021. PMID: 34025647 Free PMC article.
While engulfing apoptotic cells, phagocytes activate transcription factors, such as peroxisome proliferator-activated receptors (PPAR) or liver X receptors (LXR) that orchestrate metabolic, phagocytic, and inflammatory responses towards the ingested material. ...
While engulfing apoptotic cells, phagocytes activate transcription factors, such as peroxisome proliferator-activated receptors (PPAR …
PPAR Beta/Delta and the Hallmarks of Cancer.
Wagner N, Wagner KD. Wagner N, et al. Cells. 2020 May 4;9(5):1133. doi: 10.3390/cells9051133. Cells. 2020. PMID: 32375405 Free PMC article. Review.
Peroxisome proliferator-activated receptors (PPARs) belong to the nuclear hormone receptor family. ...They all form heterodimers with retinoic X receptors to activate or repress downstream target genes dependent on the presence/absence of ligands and coactivators or …
Peroxisome proliferator-activated receptors (PPARs) belong to the nuclear hormone receptor family. ...They all form heterodimers with …
X-linked adrenoleukodystrophy and primary adrenal insufficiency.
Cappa M, Todisco T, Bizzarri C. Cappa M, et al. Front Endocrinol (Lausanne). 2023 Nov 16;14:1309053. doi: 10.3389/fendo.2023.1309053. eCollection 2023. Front Endocrinol (Lausanne). 2023. PMID: 38034003 Free PMC article. Review.
According to population studies, X-ALD has an estimated birth prevalence of 1 in 17.000 subjects (considering both hemizygous males and heterozygous females), and there is no evidence that this prevalence varies among regions or ethnic groups. ALDP deficiency results in a defecti …
According to population studies, X-ALD has an estimated birth prevalence of 1 in 17.000 subjects (considering both hemizygous males and hete …
Emerging small molecule drugs.
Colin S, Chinetti-Gbaguidi G, Kuivenhoven JA, Staels B. Colin S, et al. Handb Exp Pharmacol. 2015;224:617-30. doi: 10.1007/978-3-319-09665-0_20. Handb Exp Pharmacol. 2015. PMID: 25523004 Review.
However, until now most therapies targeting HDL-C levels failed in clinical trials because of side effects or absence of clinical benefits. This chapter will highlight the emerging small molecules currently developed and tested in clinical trials to pharmacologically modul …
However, until now most therapies targeting HDL-C levels failed in clinical trials because of side effects or absence of clinical ben …
Bisphenol A substitutes and obesity: a review of the epidemiology and pathophysiology.
Varghese SV, Hall JM. Varghese SV, et al. Front Endocrinol (Lausanne). 2023 Jul 17;14:1155694. doi: 10.3389/fendo.2023.1155694. eCollection 2023. Front Endocrinol (Lausanne). 2023. PMID: 37529602 Free PMC article. Review.
Additional studies were assessed to explore the potential mechanisms by which these compounds act as obesogens. For BPS, these mechanisms include Peroxisome proliferator-activated receptor gamma (PPARgamma) activation, potentiation of high-fat diet induced weight-gain, and …
Additional studies were assessed to explore the potential mechanisms by which these compounds act as obesogens. For BPS, these mechanisms in …
Human peroxisomal disorders.
Depreter M, Espeel M, Roels F. Depreter M, et al. Microsc Res Tech. 2003 Jun 1;61(2):203-23. doi: 10.1002/jemt.10330. Microsc Res Tech. 2003. PMID: 12740827 Review.
Peroxisomes are single membrane-bound cell organelles performing numerous metabolic functions. ...Together with other laboratory investigations and clinical data, this approach continues to contribute to the diagnosis and further characterization of peroxisomal diso …
Peroxisomes are single membrane-bound cell organelles performing numerous metabolic functions. ...Together with other laboratory inve …
163 results