Unique mutations in the filaggrin gene in Japanese patients with ichthyosis vulgaris and atopic dermatitis.
Nomura T, Sandilands A, Akiyama M, Liao H, Evans AT, Sakai K, Ota M, Sugiura H, Yamamoto K, Sato H, Palmer CN, Smith FJ, McLean WH, Shimizu H.
Nomura T, et al.
J Allergy Clin Immunol. 2007 Feb;119(2):434-40. doi: 10.1016/j.jaci.2006.12.646.
J Allergy Clin Immunol. 2007.
PMID: 17291859
Immunohistologic and ultrastructural observations indicated that both truncation mutations lead to a striking reduction of keratohyalin granules in the epidermis. ...CLINICAL IMPLICATIONS: Filaggrin null variants are also significant predisposing factors for …
Immunohistologic and ultrastructural observations indicated that both truncation mutations lead to a striking reduction of keratoh …