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Hand size and growth in untreated and IGF-I treated patients with Laron syndrome.
Konen O, Silbergeld A, Lilos P, Kornreich L, Laron Z. Konen O, et al. J Pediatr Endocrinol Metab. 2009 Mar;22(3):235-9. doi: 10.1515/jpem.2009.22.3.235. J Pediatr Endocrinol Metab. 2009. PMID: 19492579
CONCLUSION: Congenital IGF-I deficiency, as in Laron syndrome, profoundly affects the size and growth of the hand as part of its growth retardation characteristics, resulting in acromicria....
CONCLUSION: Congenital IGF-I deficiency, as in Laron syndrome, profoundly affects the size and growth of the hand as part of its growth reta …
IGF-I replacement therapy in children with congenital IGF-I deficiency (Laron syndrome) maintains heart dimension and function.
Scheinowitz M, Feinberg MS, Laron Z. Scheinowitz M, et al. Growth Horm IGF Res. 2009 Jun;19(3):280-2. doi: 10.1016/j.ghir.2008.11.004. Epub 2008 Dec 30. Growth Horm IGF Res. 2009. PMID: 19117781
OBJECTIVE: Untreated patients with congenital growth hormone deficiency (GHD) and IGF-I deficiency are characterized not only by dwarfism but also by acromicria and organomicria, such as the heart. We assessed cardiac dimensions and function in very young patients with Lar …
OBJECTIVE: Untreated patients with congenital growth hormone deficiency (GHD) and IGF-I deficiency are characterized not only by dwarfism bu …
Consequences of not treating children with laron syndrome (primary growth hormone insensitivity).
Laron Z. Laron Z. J Pediatr Endocrinol Metab. 2001;14 Suppl 5:1243-8; discussion 1261-2. J Pediatr Endocrinol Metab. 2001. PMID: 11964019
We found that early and continuous IGF-I deficiency (the anabolic effector of growth hormone) causes dwarfism, acromicria, organomicria, marked obesity, insulin resistance, retardation of skeletal maturation and osteoporosis, as well as muscular and central nervous tissue …
We found that early and continuous IGF-I deficiency (the anabolic effector of growth hormone) causes dwarfism, acromicria, organomicr …