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73 results

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Page 1
Single-cell multiomic analysis identifies regulatory programs in mixed-phenotype acute leukemia.
Granja JM, Klemm S, McGinnis LM, Kathiria AS, Mezger A, Corces MR, Parks B, Gars E, Liedtke M, Zheng GXY, Chang HY, Majeti R, Greenleaf WJ. Granja JM, et al. Nat Biotechnol. 2019 Dec;37(12):1458-1465. doi: 10.1038/s41587-019-0332-7. Epub 2019 Dec 2. Nat Biotechnol. 2019. PMID: 31792411 Free PMC article.
Despite widespread epigenetic heterogeneity within the patient cohort, we observe common malignant signatures across patients as well as patient-specific regulatory features that are shared across phenotypic compartments of individual patients. ...
Despite widespread epigenetic heterogeneity within the patient cohort, we observe common malignant signatures across patients as well …
The Intrinsically Disordered Proteins MLLT3 (AF9) and MLLT1 (ENL) - Multimodal Transcriptional Switches With Roles in Normal Hematopoiesis, MLL Fusion Leukemia, and Kidney Cancer.
Kabra A, Bushweller J. Kabra A, et al. J Mol Biol. 2022 Jan 15;434(1):167117. doi: 10.1016/j.jmb.2021.167117. Epub 2021 Jun 23. J Mol Biol. 2022. PMID: 34174329 Free PMC article. Review.
In the context of MLL fusion patients with AML and ALL, MLL-AF9 and MLL-ENL fusions are observed in 34 and 31% of the patients, respectively. The intrinsically disordered C-terminal domain of MLLT3 (AHD, ANC1 homology domain) undergoes coupled binding and folding upon inte …
In the context of MLL fusion patients with AML and ALL, MLL-AF9 and MLL-ENL fusions are observed in 34 and 31% of the patients, respe …
Definition of acute biphenotypic leukemia.
Matutes E, Morilla R, Farahat N, Carbonell F, Swansbury J, Dyer M, Catovsky D. Matutes E, et al. Haematologica. 1997 Jan-Feb;82(1):64-6. Haematologica. 1997. PMID: 9107085 Review.
METHODS: We describe the features of 26 patients (19 adults and 7 children) with BAL diagnosed at the Royal Marsden Hospital. BAL was defined according to a scoring system devised by our group and the European Group for the Immunological Classification of Leukemia ( …
METHODS: We describe the features of 26 patients (19 adults and 7 children) with BAL diagnosed at the Royal Marsden Hospital. BAL was define …
B- and T-cell acute lymphoblastic leukemias evade chemotherapy at distinct sites in the bone marrow.
Barz MJ, Behrmann L, Capron D, Zuchtriegel G, Steffen FD, Kunz L, Zhang Y, Vermeerbergen IJ, Marovca B, Kirschmann M, Zech A, Nombela-Arrieta C, Ziegler U, Schroeder T, Bornhauser B, Bourquin JP. Barz MJ, et al. Haematologica. 2023 May 1;108(5):1244-1258. doi: 10.3324/haematol.2021.280451. Haematologica. 2023. PMID: 36325888 Free PMC article.
Persistence of residual disease after induction chemotherapy is a strong predictor of relapse in acute lymphoblastic leukemia (ALL). The bone marrow microenvironment may support escape from treatment. ...
Persistence of residual disease after induction chemotherapy is a strong predictor of relapse in acute lymphoblastic leukemia (ALL). …
Clinical characteristics and outcome of children with biphenotypic acute leukemia.
Al-Seraihy AS, Owaidah TM, Ayas M, El-Solh H, Al-Mahr M, Al-Ahmari A, Belgaumi AF. Al-Seraihy AS, et al. Haematologica. 2009 Dec;94(12):1682-90. doi: 10.3324/haematol.2009.009282. Epub 2009 Aug 27. Haematologica. 2009. PMID: 19713227 Free PMC article.
DESIGN AND METHODS: This retrospective review analyzes the clinical features and outcome of children with biphenotypic acute leukemia diagnosed and treated over an 8-year period. According to the EGIL scoring system 24 (3.7%) of 633 patients with acute leukemia were …
DESIGN AND METHODS: This retrospective review analyzes the clinical features and outcome of children with biphenotypic acute leukemia diagno …
Mixed Phenotype Acute Leukemia, B/Myeloid (Bilineal and Biphenotypic), With t(2;22)(q35;q12);EWSR1-FEV.
Montgomery-Goecker C, Koduru P, Botten G, Xu J, Ghisoli M, Goldman SC, Krueger J, Bhushan V, Fuda F, Chen W. Montgomery-Goecker C, et al. J Pediatr Hematol Oncol. 2021 Apr 1;43(3):e388-e394. doi: 10.1097/MPH.0000000000001934. J Pediatr Hematol Oncol. 2021. PMID: 32925408
BACKGROUND: Ewing sarcoma breakpoint region 1 gene (EWSR1) rearrangements are largely associated with the Ewing sarcoma family of tumors. OBSERVATIONS: We report the first case of infantile, mixed phenotype acute leukemia, B/myeloid (bilineal and biphenotypic [B-lymphoid a …
BACKGROUND: Ewing sarcoma breakpoint region 1 gene (EWSR1) rearrangements are largely associated with the Ewing sarcoma family of tumors. …
Clinical characteristics, biological profile, and outcome of biphenotypic acute leukemia: a case series.
Zhang Y, Wu D, Sun A, Qiu H, He G, Jin Z, Tang X, Miao M, Fu Z, Han Y. Zhang Y, et al. Acta Haematol. 2011;125(4):210-8. doi: 10.1159/000322594. Epub 2011 Jan 25. Acta Haematol. 2011. PMID: 21266800
METHODS: We identified 51 cases (3%) of BAL from 1,693 newly diagnosed acute leukemia patients according to the EGIL scoring system. The immunophenotyping, cytogenetics, treatment, and outcome of 39 BAL patients were retrospectively analyzed. ...
METHODS: We identified 51 cases (3%) of BAL from 1,693 newly diagnosed acute leukemia patients according to the EGIL scoring syste …
Biological features and outcome of biphenotypic acute leukemia: a case series.
Mikulic M, Batinic D, Sucic M, Davidovic-Mrsic S, Dubravcic K, Nemet D, Serventi-Seiwerth R, Sertic D, Labar B. Mikulic M, et al. Hematol Oncol Stem Cell Ther. 2008 Oct-Dec;1(4):225-30. doi: 10.1016/s1658-3876(08)50009-4. Hematol Oncol Stem Cell Ther. 2008. PMID: 20058478 Free article.
BACKGROUND: Biphenotypic acute leukemia (BAL) is a distinct entity that is immunophenotypically defined by the European Group for the Immunological Classification of Leukemia (EGIL) scoring system and accounts for less than 5% of all acute leukemia cases. ...
BACKGROUND: Biphenotypic acute leukemia (BAL) is a distinct entity that is immunophenotypically defined by the European Group for the Immuno …
Mixed Phenotype Acute Leukemia with t(12;17)(p13;q21)/TAF15-ZNF384 and Other Chromosome Abnormalities.
Yamamoto K, Kawamoto S, Mizutani Y, Yakushijin K, Yamashita T, Nakamachi Y, Kawano S, Hayashi Y, Matsuoka H, Minami H. Yamamoto K, et al. Cytogenet Genome Res. 2016;149(3):165-170. doi: 10.1159/000448447. Epub 2016 Sep 9. Cytogenet Genome Res. 2016. PMID: 27607436 Review.
The t(12;17)(p13;q1121) translocation is a very rare but recurrent cytogenetic aberration observed predominantly in early pre-B acute lymphoblastic leukemia (ALL) with CD19+CD10-CD33+ phenotype. ...
The t(12;17)(p13;q1121) translocation is a very rare but recurrent cytogenetic aberration observed predominantly in early pre-B acute …
A Case of Acute Mixed Cell Leukemia Resembling AML1-ETO Positive Acute Myeloid Leukemia.
Li R, Wu Y, Zhang X, Wang L, Zhang Y, Xiao H. Li R, et al. Clin Lab. 2023 Apr 1;69(4). doi: 10.7754/Clin.Lab.2022.220723. Clin Lab. 2023. PMID: 37057942
Typical Auer bodies, pseudo Chadiak-Higashi granules and phagocytic erythroid substances were observed. The nuclei are irregular in shape, distorted and depressed, with fine chromatin and prominent large nucleoli. ...
Typical Auer bodies, pseudo Chadiak-Higashi granules and phagocytic erythroid substances were observed. The nuclei are irregular in s …
73 results