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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1990 1
1991 3
1992 2
1994 3
1995 1
1996 2
1997 1
1998 4
2000 4
2002 1
2003 1
2004 2
2005 1
2006 4
2007 2
2008 4
2009 9
2010 1
2011 5
2012 10
2013 10
2014 9
2015 7
2016 8
2017 9
2018 5
2019 7
2020 9
2021 7
2022 3
2023 1
2024 2

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126 results

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Page 1
Mixed-phenotype acute leukemia: state-of-the-art of the diagnosis, classification and treatment.
Cernan M, Szotkowski T, Pikalova Z. Cernan M, et al. Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2017 Sep;161(3):234-241. doi: 10.5507/bp.2017.013. Epub 2017 Apr 18. Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2017. PMID: 28422191 Free article. Review.
Because adverse cytogenetic abnormalities are frequently present, MPAL is generally considered a disease with a poor prognosis. Knowledge of its treatment is limited to retrospective analyses of small patient cohorts. ...This review summarizes current knowledge on the diag …
Because adverse cytogenetic abnormalities are frequently present, MPAL is generally considered a disease with a poor prognosis. Knowl …
Genetic Testing in the Diagnosis and Biology of Acute Leukemia.
Harris MH, Czuchlewski DR, Arber DA, Czader M. Harris MH, et al. Am J Clin Pathol. 2019 Aug 1;152(3):322-346. doi: 10.1093/ajcp/aqz093. Am J Clin Pathol. 2019. PMID: 31367767 Review.
Many cases demonstrated genetic alterations of known diagnostic, prognostic, and/or therapeutic significance, while others exhibited alterations that illuminated disease biology. ...
Many cases demonstrated genetic alterations of known diagnostic, prognostic, and/or therapeutic significance, while others exhibited …
Mixed phenotype acute leukemia.
Ye Z, Wang S. Ye Z, et al. Chin Med J (Engl). 2014;127(16):2999-3003. Chin Med J (Engl). 2014. PMID: 25131241 Review.
The lack of effective treatment contributes to an undesirable prognosis. CONCLUSION: Our understanding about MPAL is still limited. The diagnostic criteria have not been unified. The treatment of MPAL remains to be investigated. The prognostic factor is largely uncl …
The lack of effective treatment contributes to an undesirable prognosis. CONCLUSION: Our understanding about MPAL is still limited. T …
Acute Leukemias of Ambiguous Lineage: Clarification on Lineage Specificity.
Kurzer JH, Weinberg OK. Kurzer JH, et al. Surg Pathol Clin. 2019 Sep;12(3):687-697. doi: 10.1016/j.path.2019.03.008. Surg Pathol Clin. 2019. PMID: 31352981 Review.
In addition, the currently known molecular data are reviewed, which show that MPAL-associated gene mutations, methylation signatures, and expression profiles are a mixture of those seen in both acute myeloid leukemia and acute lymphoblastic leukemia. Finally, the prognosis …
In addition, the currently known molecular data are reviewed, which show that MPAL-associated gene mutations, methylation signatures, and ex …
An update on classification, genetics, and clinical approach to mixed phenotype acute leukemia (MPAL).
Khan M, Siddiqi R, Naqvi K. Khan M, et al. Ann Hematol. 2018 Jun;97(6):945-953. doi: 10.1007/s00277-018-3297-6. Epub 2018 Mar 15. Ann Hematol. 2018. PMID: 29546454 Review.
Based on the 2008 and 2016 World Health Organization classifications, myeloid lineage is best determined by presence of myeloperoxidase, while B and T lymphoid lineages are demonstrated by CD19 and cytoplasmic CD3 expression. MPAL typically carries a worse prognosis than e …
Based on the 2008 and 2016 World Health Organization classifications, myeloid lineage is best determined by presence of myeloperoxidase, whi …
Definition of acute biphenotypic leukemia.
Matutes E, Morilla R, Farahat N, Carbonell F, Swansbury J, Dyer M, Catovsky D. Matutes E, et al. Haematologica. 1997 Jan-Feb;82(1):64-6. Haematologica. 1997. PMID: 9107085 Review.
BAL has a high incidence of clonal chromosomal abnormalities, the most common being the t(9;22) (q34;q11) (Ph chromosome) and structural abnormalities involving 11q23. Data are emerging that BAL has a negative prognosis in both children and adults and this may be related t …
BAL has a high incidence of clonal chromosomal abnormalities, the most common being the t(9;22) (q34;q11) (Ph chromosome) and structural abn …
Acute leukemias of ambiguous lineage.
Béné MC, Porwit A. Béné MC, et al. Semin Diagn Pathol. 2012 Feb;29(1):12-8. doi: 10.1053/j.semdp.2011.08.004. Semin Diagn Pathol. 2012. PMID: 22372202 Review.
Other MPAL are divided into B/myeloid NOS, T/myeloid NOS, B/T NOS, and B/T/myeloid NOS. MPAL are usually of dire prognosis, respond variably to chemotherapy of acute lymphoblastic or acute myeloblastic type, and benefit most from rapid allogeneic hematopoietic stem cell tr …
Other MPAL are divided into B/myeloid NOS, T/myeloid NOS, B/T NOS, and B/T/myeloid NOS. MPAL are usually of dire prognosis, respond v …
B- and T-cell acute lymphoblastic leukemias evade chemotherapy at distinct sites in the bone marrow.
Barz MJ, Behrmann L, Capron D, Zuchtriegel G, Steffen FD, Kunz L, Zhang Y, Vermeerbergen IJ, Marovca B, Kirschmann M, Zech A, Nombela-Arrieta C, Ziegler U, Schroeder T, Bornhauser B, Bourquin JP. Barz MJ, et al. Haematologica. 2023 May 1;108(5):1244-1258. doi: 10.3324/haematol.2021.280451. Haematologica. 2023. PMID: 36325888 Free PMC article.
Persistence of residual disease after induction chemotherapy is a strong predictor of relapse in acute lymphoblastic leukemia (ALL). The bone marrow microenvironment may support escape from treatment. ...
Persistence of residual disease after induction chemotherapy is a strong predictor of relapse in acute lymphoblastic leukemia (ALL). …
Multiparameter flow cytometry applications in the diagnosis of mixed phenotype acute leukemia.
Porwit A, Béné MC. Porwit A, et al. Cytometry B Clin Cytom. 2019 May;96(3):183-194. doi: 10.1002/cyto.b.21783. Epub 2019 Apr 29. Cytometry B Clin Cytom. 2019. PMID: 31033213 Free article. Review.
Mixed phenotype acute leukemias (MPALs) represent a rare subgroup of acute leukemias with a poor prognosis. Proper diagnosis and classification of MPAL is extremely important for patients' outcome. ...
Mixed phenotype acute leukemias (MPALs) represent a rare subgroup of acute leukemias with a poor prognosis. Proper diagnosis and clas …
126 results