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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
2003 1
2008 1
2009 1
2010 1
2011 1
2012 1
2013 1
2014 1
2015 1
2017 4
2018 1
2019 1
2020 1
2021 1
2024 1

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15 results

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Page 1
Expectations, validity, and reality in pharmacogenetics.
Limdi NA, Veenstra DL. Limdi NA, et al. J Clin Epidemiol. 2010 Sep;63(9):960-9. doi: 10.1016/j.jclinepi.2009.09.006. Epub 2009 Dec 7. J Clin Epidemiol. 2010. PMID: 19995676 Free PMC article. Review.
In this review, we discuss the potential expectations, validity, predictive ability, and reality of pharmacogenetics in (1) titration of medication dose, (2) prediction of intended (efficacy) drug response, and (3) dose prediction of unintended (adverse …
In this review, we discuss the potential expectations, validity, predictive ability, and reality of pharmacogenetics in (1) titration …
Reverse Translational Research of ABCG2 (BCRP) in Human Disease and Drug Response.
Brackman DJ, Giacomini KM. Brackman DJ, et al. Clin Pharmacol Ther. 2018 Feb;103(2):233-242. doi: 10.1002/cpt.903. Epub 2017 Nov 28. Clin Pharmacol Ther. 2018. PMID: 29023674 Free PMC article. Review.
Reverse translational research takes a bedside-to-bench approach, using sophisticated basic research to explain the biological mechanisms behind observed clinical data. For transporters, which play a role in human disease and drug response, this approach offers a distinct …
Reverse translational research takes a bedside-to-bench approach, using sophisticated basic research to explain the biological mechanisms be …
Advances in human cytochrome p450 and personalized medicine.
Chen Q, Zhang T, Wang JF, Wei DQ. Chen Q, et al. Curr Drug Metab. 2011 Jun;12(5):436-44. doi: 10.2174/138920011795495259. Curr Drug Metab. 2011. PMID: 21453272 Review.
As variations of Single Nucleotide Polymorphism (SNPs) in human CYP450 genes will cause different drug effects and even adverse effects, studies on SNPs of human CYP450 genes can be used for indicating the most possible genes associated with human diseases and relevant therapeuti …
As variations of Single Nucleotide Polymorphism (SNPs) in human CYP450 genes will cause different drug effects and even adverse effects, stu …
Drug Metabolites Potently Inhibit Renal Organic Anion Transporters, OAT1 and OAT3.
Zou L, Matsson P, Stecula A, Ngo HX, Zur AA, Giacomini KM. Zou L, et al. J Pharm Sci. 2021 Jan;110(1):347-353. doi: 10.1016/j.xphs.2020.09.004. Epub 2020 Sep 7. J Pharm Sci. 2021. PMID: 32910949 Free PMC article.
Seven drug metabolites were potent inhibitors of either or both OAT1 and OAT3 with K(i) values less than 1 muM. 22 metabolites were more potent inhibitors of OAT3 than OAT1. Importantly, one drug and four metabolites were predicted to inhibit OAT3 at unbound plasma concent …
Seven drug metabolites were potent inhibitors of either or both OAT1 and OAT3 with K(i) values less than 1 muM. 22 metabolites were more pot …
Understanding drug-induced torsades de pointes: a genetic stance.
Kannankeril PJ. Kannankeril PJ. Expert Opin Drug Saf. 2008 May;7(3):231-9. doi: 10.1517/14740338.7.3.231. Expert Opin Drug Saf. 2008. PMID: 18462182 Review.
The wide array of drugs with potential for QT prolongation, the correspondingly large number of patients exposed to such drugs, the difficulty in predicting an individual's risk, and the potentially fatal outcome, make drug-induced long QT syndrome an important public heal …
The wide array of drugs with potential for QT prolongation, the correspondingly large number of patients exposed to such drugs, the difficul …
Evaluation of Batch Variations in Induced Pluripotent Stem Cell-Derived Human Cardiomyocytes from 2 Major Suppliers.
Huo J, Kamalakar A, Yang X, Word B, Stockbridge N, Lyn-Cook B, Pang L. Huo J, et al. Toxicol Sci. 2017 Mar 1;156(1):25-38. doi: 10.1093/toxsci/kfw235. Toxicol Sci. 2017. PMID: 28031415
Drug-induced proarrhythmia is a major safety issue in drug development. Developing sensitive in vitro assays that can predict drug-induced cardiotoxicity in humans has been a challenge of toxicology research for decades. ...Patient-specific iPSC-hCMs have been proposed for …
Drug-induced proarrhythmia is a major safety issue in drug development. Developing sensitive in vitro assays that can predict drug-in …
Human cytochrome P450 and personalized medicine.
Chen Q, Wei D. Chen Q, et al. Adv Exp Med Biol. 2015;827:341-51. doi: 10.1007/978-94-017-9245-5_20. Adv Exp Med Biol. 2015. PMID: 25387974
Thus bioinformatics studies on SNPs of human CYP450 genes will contribute to indicate the most possible genes that are associated with human diseases and relevant therapeutic targets, identify and predict the drug efficacy and adverse drug response, in …
Thus bioinformatics studies on SNPs of human CYP450 genes will contribute to indicate the most possible genes that are associated with human …
OCT1 genetic variants are associated with postoperative morphine-related adverse effects in children.
Balyan R, Zhang X, Chidambaran V, Martin LJ, Mizuno T, Fukuda T, Vinks AA, Sadhasivam S. Balyan R, et al. Pharmacogenomics. 2017 May;18(7):621-629. doi: 10.2217/pgs-2017-0002. Epub 2017 May 4. Pharmacogenomics. 2017. PMID: 28470102 Free PMC article.
Respiratory depression (RD) and postoperative nausea and vomiting (PONV) are significant adverse drug response of intravenous morphine in the perioperative setting limiting its efficacy in achieving adequate surgical pain relief. ...There were incidences of p …
Respiratory depression (RD) and postoperative nausea and vomiting (PONV) are significant adverse drug response of intra …
The IKr drug response is modulated by KCR1 in transfected cardiac and noncardiac cell lines.
Kupershmidt S, Yang IC, Hayashi K, Wei J, Chanthaphaychith S, Petersen CI, Johns DC, George AL Jr, Roden DM, Balser JR. Kupershmidt S, et al. FASEB J. 2003 Dec;17(15):2263-5. doi: 10.1096/fj.02-1057fje. Epub 2003 Oct 2. FASEB J. 2003. PMID: 14525949
Even transient exposure to such agents may provoke the life-threatening cardiac arrhythmia torsades de pointes in some, but not all, individuals. Although the molecular and genetic factors predicting such wide variability in drug response remain unclear, known sequence var …
Even transient exposure to such agents may provoke the life-threatening cardiac arrhythmia torsades de pointes in some, but not all, individ …
Genetic variants influencing fluoropyrimidine based-therapy and available methods to detect them.
Di Francia R, Cimino L, Berretta M. Di Francia R, et al. Eur Rev Med Pharmacol Sci. 2012 Mar;16(3):285-98. Eur Rev Med Pharmacol Sci. 2012. PMID: 22530343 Review.
A multitude of methods has been applied to assess the mutational status of these genes, without defining a golden standard for the daily diagnostic routine, so far. AIMS: Some adverse drug response due to the administration of 5-FU can be predicted thr …
A multitude of methods has been applied to assess the mutational status of these genes, without defining a golden standard for the daily dia …
15 results