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Page 1
Mouse Population-Based Approaches to Investigate Adverse Drug Reactions.
Mosedale M. Mosedale M. Drug Metab Dispos. 2018 Nov;46(11):1787-1795. doi: 10.1124/dmd.118.082834. Epub 2018 Jul 25. Drug Metab Dispos. 2018. PMID: 30045843 Review.
This review describes genetically diverse mouse populations and provides examples of their utility in investigating adverse drug response. It also explores recent efforts to adapt mouse population-based approaches to in vitro platforms, thereby enabling the i …
This review describes genetically diverse mouse populations and provides examples of their utility in investigating adverse drug …
Reverse Translational Research of ABCG2 (BCRP) in Human Disease and Drug Response.
Brackman DJ, Giacomini KM. Brackman DJ, et al. Clin Pharmacol Ther. 2018 Feb;103(2):233-242. doi: 10.1002/cpt.903. Epub 2017 Nov 28. Clin Pharmacol Ther. 2018. PMID: 29023674 Free PMC article. Review.
Research on ABCG2, which encodes the Breast Cancer Resistance Protein, has benefited immensely from a reverse translational approach due to its broad implications for disease susceptibility and both therapeutic and adverse drug response. In this review, we de …
Research on ABCG2, which encodes the Breast Cancer Resistance Protein, has benefited immensely from a reverse translational approach due to …
Regulation of drug metabolism and disposition during inflammation and infection.
Renton KW. Renton KW. Expert Opin Drug Metab Toxicol. 2005 Dec;1(4):629-40. doi: 10.1517/17425255.1.4.629. Expert Opin Drug Metab Toxicol. 2005. PMID: 16863429 Review.
For any drug that is metabolised by CYP and has a narrow therapeutic index, there is a significant risk in placing patients in a position where an infection or inflammatory response might lead to aberrant drug handling and an adverse drug response....
For any drug that is metabolised by CYP and has a narrow therapeutic index, there is a significant risk in placing patients in a position wh …
Understanding drug-induced torsades de pointes: a genetic stance.
Kannankeril PJ. Kannankeril PJ. Expert Opin Drug Saf. 2008 May;7(3):231-9. doi: 10.1517/14740338.7.3.231. Expert Opin Drug Saf. 2008. PMID: 18462182 Review.
The post-genomic era hints at an improved understanding (and prediction) of how the gene-environment interaction produces this particular adverse drug response....
The post-genomic era hints at an improved understanding (and prediction) of how the gene-environment interaction produces this particular …
OCT1 genetic variants are associated with postoperative morphine-related adverse effects in children.
Balyan R, Zhang X, Chidambaran V, Martin LJ, Mizuno T, Fukuda T, Vinks AA, Sadhasivam S. Balyan R, et al. Pharmacogenomics. 2017 May;18(7):621-629. doi: 10.2217/pgs-2017-0002. Epub 2017 May 4. Pharmacogenomics. 2017. PMID: 28470102 Free PMC article.
Respiratory depression (RD) and postoperative nausea and vomiting (PONV) are significant adverse drug response of intravenous morphine in the perioperative setting limiting its efficacy in achieving adequate surgical pain relief. ...
Respiratory depression (RD) and postoperative nausea and vomiting (PONV) are significant adverse drug response of intra …
Predictors of gastrointestinal bleeding in older persons taking nonsteroidal anti-inflammatory drugs: Results from the FDA adverse events reporting system.
McDonald DD. McDonald DD. J Am Assoc Nurse Pract. 2019 Mar;31(3):206-213. doi: 10.1097/JXX.0000000000000130. J Am Assoc Nurse Pract. 2019. PMID: 30589757
Data included age, sex, NSAID, multiple NSAID use, rivaroxaban, warfarin, clopidogrel, cardiovascular drug (proxy for cardiovascular disease), diabetes drug (proxy for diabetes mellitus), and primary adverse drug response. CONCLUSIONS: Aspirin was the primary …
Data included age, sex, NSAID, multiple NSAID use, rivaroxaban, warfarin, clopidogrel, cardiovascular drug (proxy for cardiovascular disease …
In Vivo Functional Effects of CYP2C9 M1L, a Novel and Common Variant in the Yup'ik Alaska Native Population.
Henderson LM, Hopkins SE, Boyer BB, Thornton TA, Rettie AE, Thummel KE. Henderson LM, et al. Drug Metab Dispos. 2021 May;49(5):345-352. doi: 10.1124/dmd.120.000301. Epub 2021 Feb 25. Drug Metab Dispos. 2021. PMID: 33632714 Free PMC article.
M1L is present at a minor allele frequency of 6.3% in Yup'ik Alaska Native people and thus can contribute to the risk of an adverse drug response from narrow-therapeutic-index CYP2C9 substrates such as (S)-warfarin. ...
M1L is present at a minor allele frequency of 6.3% in Yup'ik Alaska Native people and thus can contribute to the risk of an adverse …
Enhancement of hepatic 4-hydroxylation of 25-hydroxyvitamin D3 through CYP3A4 induction in vitro and in vivo: implications for drug-induced osteomalacia.
Wang Z, Lin YS, Dickmann LJ, Poulton EJ, Eaton DL, Lampe JW, Shen DD, Davis CL, Shuhart MC, Thummel KE. Wang Z, et al. J Bone Miner Res. 2013 May;28(5):1101-16. doi: 10.1002/jbmr.1839. J Bone Miner Res. 2013. PMID: 23212742 Free PMC article.
Human CYP24A1, CYP3A4, and CYP27B1 catalyze the inactivation and activation of vitamin D and have been implicated in the adverse drug response. In this study, the inducibility of these enzymes and monohydroxylation of 25-hydroxyvitamin D3 (25OHD3) were evalua …
Human CYP24A1, CYP3A4, and CYP27B1 catalyze the inactivation and activation of vitamin D and have been implicated in the adverse d …