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Page 1
Expectations, validity, and reality in pharmacogenetics.
Limdi NA, Veenstra DL. Limdi NA, et al. J Clin Epidemiol. 2010 Sep;63(9):960-9. doi: 10.1016/j.jclinepi.2009.09.006. Epub 2009 Dec 7. J Clin Epidemiol. 2010. PMID: 19995676 Free PMC article. Review.
In this review, we discuss the potential expectations, validity, predictive ability, and reality of pharmacogenetics in (1) titration of medication dose, (2) prediction of intended (efficacy) drug response, and (3) dose prediction of unintended (adverse) drug …
In this review, we discuss the potential expectations, validity, predictive ability, and reality of pharmacogenetics in (1) titration …
Advances in human cytochrome p450 and personalized medicine.
Chen Q, Zhang T, Wang JF, Wei DQ. Chen Q, et al. Curr Drug Metab. 2011 Jun;12(5):436-44. doi: 10.2174/138920011795495259. Curr Drug Metab. 2011. PMID: 21453272 Review.
As variations of Single Nucleotide Polymorphism (SNPs) in human CYP450 genes will cause different drug effects and even adverse effects, studies on SNPs of human CYP450 genes can be used for indicating the most possible genes associated with human diseases and relevant therapeuti …
As variations of Single Nucleotide Polymorphism (SNPs) in human CYP450 genes will cause different drug effects and even adverse effects, stu …
Drug Metabolites Potently Inhibit Renal Organic Anion Transporters, OAT1 and OAT3.
Zou L, Matsson P, Stecula A, Ngo HX, Zur AA, Giacomini KM. Zou L, et al. J Pharm Sci. 2021 Jan;110(1):347-353. doi: 10.1016/j.xphs.2020.09.004. Epub 2020 Sep 7. J Pharm Sci. 2021. PMID: 32910949 Free PMC article.
Seven drug metabolites were potent inhibitors of either or both OAT1 and OAT3 with K(i) values less than 1 muM. 22 metabolites were more potent inhibitors of OAT3 than OAT1. Importantly, one drug and four metabolites were predicted to inhibit OAT3 at unbound plasma concent …
Seven drug metabolites were potent inhibitors of either or both OAT1 and OAT3 with K(i) values less than 1 muM. 22 metabolites were more pot …
Understanding drug-induced torsades de pointes: a genetic stance.
Kannankeril PJ. Kannankeril PJ. Expert Opin Drug Saf. 2008 May;7(3):231-9. doi: 10.1517/14740338.7.3.231. Expert Opin Drug Saf. 2008. PMID: 18462182 Review.
The wide array of drugs with potential for QT prolongation, the correspondingly large number of patients exposed to such drugs, the difficulty in predicting an individual's risk, and the potentially fatal outcome, make drug-induced long QT syndrome an important public heal …
The wide array of drugs with potential for QT prolongation, the correspondingly large number of patients exposed to such drugs, the difficul …
Human cytochrome P450 and personalized medicine.
Chen Q, Wei D. Chen Q, et al. Adv Exp Med Biol. 2015;827:341-51. doi: 10.1007/978-94-017-9245-5_20. Adv Exp Med Biol. 2015. PMID: 25387974
Thus bioinformatics studies on SNPs of human CYP450 genes will contribute to indicate the most possible genes that are associated with human diseases and relevant therapeutic targets, identify and predict the drug efficacy and adverse drug response, investigate individual …
Thus bioinformatics studies on SNPs of human CYP450 genes will contribute to indicate the most possible genes that are associated with human …
Evaluation of Batch Variations in Induced Pluripotent Stem Cell-Derived Human Cardiomyocytes from 2 Major Suppliers.
Huo J, Kamalakar A, Yang X, Word B, Stockbridge N, Lyn-Cook B, Pang L. Huo J, et al. Toxicol Sci. 2017 Mar 1;156(1):25-38. doi: 10.1093/toxsci/kfw235. Toxicol Sci. 2017. PMID: 28031415
Drug-induced proarrhythmia is a major safety issue in drug development. Developing sensitive in vitro assays that can predict drug-induced cardiotoxicity in humans has been a challenge of toxicology research for decades. ...Patient-specific iPSC-hCMs have been proposed for …
Drug-induced proarrhythmia is a major safety issue in drug development. Developing sensitive in vitro assays that can predict drug-in …
The IKr drug response is modulated by KCR1 in transfected cardiac and noncardiac cell lines.
Kupershmidt S, Yang IC, Hayashi K, Wei J, Chanthaphaychith S, Petersen CI, Johns DC, George AL Jr, Roden DM, Balser JR. Kupershmidt S, et al. FASEB J. 2003 Dec;17(15):2263-5. doi: 10.1096/fj.02-1057fje. Epub 2003 Oct 2. FASEB J. 2003. PMID: 14525949
Even transient exposure to such agents may provoke the life-threatening cardiac arrhythmia torsades de pointes in some, but not all, individuals. Although the molecular and genetic factors predicting such wide variability in drug response remain unclear, known sequence var …
Even transient exposure to such agents may provoke the life-threatening cardiac arrhythmia torsades de pointes in some, but not all, individ …
Genetic variants influencing fluoropyrimidine based-therapy and available methods to detect them.
Di Francia R, Cimino L, Berretta M. Di Francia R, et al. Eur Rev Med Pharmacol Sci. 2012 Mar;16(3):285-98. Eur Rev Med Pharmacol Sci. 2012. PMID: 22530343 Review.
AIMS: Some adverse drug response due to the administration of 5-FU can be predicted through pharmacogenomics testing tools. This report reviews the recent findings on the polymorphism for genes that are involved in the biotransformation of the drug and its association with …
AIMS: Some adverse drug response due to the administration of 5-FU can be predicted through pharmacogenomics testing tools. This repo …
APF2: an improved ensemble method for pharmacogenomic variant effect prediction.
Zhou Y, Pirmann S, Lauschke VM. Zhou Y, et al. Pharmacogenomics J. 2024 May 27;24(3):17. doi: 10.1038/s41397-024-00338-x. Pharmacogenomics J. 2024. PMID: 38802404 Free PMC article.
To overcome this limitation, we previously developed an ensemble classifier, termed APF, specifically designed for pharmacogenomic variant prediction. Here, we aimed to further improve predictions by leveraging recent key advances in the prediction of protein …
To overcome this limitation, we previously developed an ensemble classifier, termed APF, specifically designed for pharmacogenomic variant …
Predictors of gastrointestinal bleeding in older persons taking nonsteroidal anti-inflammatory drugs: Results from the FDA adverse events reporting system.
McDonald DD. McDonald DD. J Am Assoc Nurse Pract. 2019 Mar;31(3):206-213. doi: 10.1097/JXX.0000000000000130. J Am Assoc Nurse Pract. 2019. PMID: 30589757
BACKGROUND AND PURPOSE: Older adults continue to take nonsteroidal anti-inflammatory drugs (NSAIDs) to manage chronic pain. The study's purpose was to identify predictors of gastrointestinal (GI) bleeding in older adults taking NSAIDs. ...Rivaroxaban was taken in 67.9% of …
BACKGROUND AND PURPOSE: Older adults continue to take nonsteroidal anti-inflammatory drugs (NSAIDs) to manage chronic pain. The study's purp …
12 results