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Common genetic variation in alcohol-related hepatocellular carcinoma: a case-control genome-wide association study.
Trépo E, Caruso S, Yang J, Imbeaud S, Couchy G, Bayard Q, Letouzé E, Ganne-Carrié N, Moreno C, Oussalah A, Féray C, Blanc JF, Clément B, Hillon P, Boursier J, Paradis V, Calderaro J, Gnemmi V, Nault JC, Guéant JL, Devière J, Archambeaud I, Vitellius C, Turlin B, Bronowicki JP, Gustot T, Sutton A; GENTHEP Consortium; Ziol M, Nahon P, Zucman-Rossi J. Trépo E, et al. Lancet Oncol. 2022 Jan;23(1):161-171. doi: 10.1016/S1470-2045(21)00603-3. Epub 2021 Dec 11. Lancet Oncol. 2022. PMID: 34902334 Free article.
Cases were patients with alcohol-related hepatocellular carcinoma diagnosed by imaging or histology. ...Adjustment for clinical covariates yielded similar results. We observed an additive effect of at-risk alleles on alcohol-related …
Cases were patients with alcohol-related hepatocellular carcinoma diagnosed by imaging or histology. ...Adjustme …
Constitutional and functional genetics of human alcohol-related hepatocellular carcinoma.
Nahon P, Nault JC. Nahon P, et al. Liver Int. 2017 Nov;37(11):1591-1601. doi: 10.1111/liv.13419. Epub 2017 Apr 11. Liver Int. 2017. PMID: 28296015 Review.
Specific patterns of gene mutations including CTNNB1, TERT, ARID1A and SMARCA2 exist in alcohol-related HCC. Moreover, a specific mutational process observed at the nucleotide level by next generation sequencing has revealed cooperation between alcohol and tobacco in the d …
Specific patterns of gene mutations including CTNNB1, TERT, ARID1A and SMARCA2 exist in alcohol-related HCC. Moreover, a specific mutational …
Comparisons between non-alcoholic steatohepatitis and alcohol-related hepatocellular carcinoma.
Kumar R, Goh BG, Kam JW, Chang PE, Tan CK. Kumar R, et al. Clin Mol Hepatol. 2020 Apr;26(2):196-208. doi: 10.3350/cmh.2019.0012. Epub 2020 Jan 9. Clin Mol Hepatol. 2020. PMID: 31914720 Free PMC article.
Prevalence of diabetes mellitus (78% vs. 36%, P<0.001) and hypertension (80% vs. 58%, P<0.001) were significantly higher in the NASH-HCC group. Liver function tests and Child-Pugh scores were similar. There were no differences in alpha-fetoprotein level, lesions foun …
Prevalence of diabetes mellitus (78% vs. 36%, P<0.001) and hypertension (80% vs. 58%, P<0.001) were significantly higher in the NASH-H …
Long non-coding RNA-based risk scoring system predicts prognosis of alcohol-related hepatocellular carcinoma.
Luo Y, Ye J, Wei J, Zhang J, Li Y. Luo Y, et al. Mol Med Rep. 2020 Aug;22(2):997-1007. doi: 10.3892/mmr.2020.11179. Epub 2020 May 22. Mol Med Rep. 2020. PMID: 32468063 Free PMC article.
Cox regression analysis was performed to identify prognosis-associated lncRNAs and select the optimal lncRNA model. A risk scoring system was established to calculate the risk score for each patient. ...The area under the receiver operating characteristic (RO …
Cox regression analysis was performed to identify prognosis-associated lncRNAs and select the optimal lncRNA model. A risk scoring …
Comparison of survival outcomes of alcohol-related hepatocellular carcinoma with or without liver cirrhosis; a ten-year experience.
Shin J, Yu JH, Jin YJ, Chae MH, Yoon CH, Lee JW. Shin J, et al. Medicine (Baltimore). 2019 Nov;98(47):e18020. doi: 10.1097/MD.0000000000018020. Medicine (Baltimore). 2019. PMID: 31764818 Free PMC article.
We evaluated overall survivals (OSs) of alcohol-related hepatocellular carcinoma (HCC) patients without LC compared to those with LC.Between 2005 and 2015, 1343 patients were initially diagnosed as having HCC in our hospital. ...Multivariate analyses r …
We evaluated overall survivals (OSs) of alcohol-related hepatocellular carcinoma (HCC) patients without LC compa …
Mass-selected site-specific core-fucosylation of ceruloplasmin in alcohol-related hepatocellular carcinoma.
Yin H, Lin Z, Nie S, Wu J, Tan Z, Zhu J, Dai J, Feng Z, Marrero J, Lubman DM. Yin H, et al. J Proteome Res. 2014 Jun 6;13(6):2887-96. doi: 10.1021/pr500043k. Epub 2014 May 15. J Proteome Res. 2014. PMID: 24799124 Free PMC article.
However, in HBV- or HCV-related liver diseases, no significant site-specific change in core-fucosylation of ceruloplasmin was observed between HCC and cirrhosis....
However, in HBV- or HCV-related liver diseases, no significant site-specific change in core-fucosylation of ceruloplasmin was observed …
Hepatocellular carcinoma: comparison of clinical features among ethnic groups in an area of low prevalence.
Poenaru D, Szilagyi A, Zabad F, Lamoureux E, Lough JO. Poenaru D, et al. Am J Gastroenterol. 1991 Apr;86(4):487-94. Am J Gastroenterol. 1991. PMID: 1849345
In this fashion, differences in clinical presentation were observed. Asians (N = 12) were younger, invariably presented with pain; 82% had markers of hepatitis B and did not have features of chronic liver disease. ...A logistic regression model clinically separated patient …
In this fashion, differences in clinical presentation were observed. Asians (N = 12) were younger, invariably presented with pain; 82 …