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Year Number of Results
2000 1
2001 1
2002 4
2003 1
2005 1
2006 7
2007 1
2008 4
2009 3
2010 6
2011 6
2012 8
2013 6
2014 2
2015 1
2018 2
2019 6
2020 3
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2024 6

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69 results

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Page 1
Adult Leukodystrophies: A Step-by-Step Diagnostic Approach.
Resende LL, de Paiva ARB, Kok F, da Costa Leite C, Lucato LT. Resende LL, et al. Radiographics. 2019 Jan-Feb;39(1):153-168. doi: 10.1148/rg.2019180081. Radiographics. 2019. PMID: 30620693 Review.
The first step is to identify symmetric white matter involvement, which is more commonly observed in these patients. The next step is to fit the symmetric white matter involvement into one of the proposed patterns. ...
The first step is to identify symmetric white matter involvement, which is more commonly observed in these patients. The next step is …
Alexander disease: The story behind an eponym.
Anderson NE, Alexander HS, Messing A. Anderson NE, et al. J Hist Neurosci. 2023 Oct-Dec;32(4):399-422. doi: 10.1080/0964704X.2023.2190354. Epub 2023 Mar 31. J Hist Neurosci. 2023. PMID: 37000960
Although the clinical, imaging, and pathological manifestations of Alexander disease are now well known, few people are familiar with Alexander's career. Although he did not make a further contribution to the literature on Alexander disease, his obs …
Although the clinical, imaging, and pathological manifestations of Alexander disease are now well known, few people are famili …
Epilepsy in children with leukodystrophies.
Zhang J, Ban T, Zhou L, Ji H, Yan H, Shi Z, Cao B, Jiang Y, Wang J, Wu Y. Zhang J, et al. J Neurol. 2020 Sep;267(9):2612-2618. doi: 10.1007/s00415-020-09889-y. Epub 2020 May 9. J Neurol. 2020. PMID: 32388833
RESULTS: A total of 333 patients were included. The overall incidence of epilepsy was 30.6% (102/333). Alexander disease had the highest incidence (77.3%, 51/66), followed by vanishing white matter disease (41.2%, 21/51), Canavan disease (33.3%, 1/3), megalencephali …
RESULTS: A total of 333 patients were included. The overall incidence of epilepsy was 30.6% (102/333). Alexander disease had t …
Clinical aspects and pathology of Alexander disease, and morphological and functional alteration of astrocytes induced by GFAP mutation.
Yoshida T, Nakagawa M. Yoshida T, et al. Neuropathology. 2012 Aug;32(4):440-6. doi: 10.1111/j.1440-1789.2011.01268.x. Epub 2011 Nov 28. Neuropathology. 2012. PMID: 22118268 Review.
Alexander disease (AxD) is pathologically characterized by the presence of Rosenthal fibers (RF), which are made up of GFAP, alphaB-crystallin and heat shock protein 27, in the cytoplasm of perivascular and subpial astrocyte endfeet. ...We conducted a nationwide sur …
Alexander disease (AxD) is pathologically characterized by the presence of Rosenthal fibers (RF), which are made up of GFAP, a …
Alexander's disease: reassessment of a neonatal form.
Singh N, Bixby C, Etienne D, Tubbs RS, Loukas M. Singh N, et al. Childs Nerv Syst. 2012 Dec;28(12):2029-31. doi: 10.1007/s00381-012-1868-8. Epub 2012 Aug 14. Childs Nerv Syst. 2012. PMID: 22890470 Review.
INTRODUCTION: Alexander disease is a disorder caused by a mutation and accumulation of the glial fibrillary acidic protein. ...While the infantile form presents with ataxia, hyperreflexia, and other upper motor neuron symptoms, none of these has been observed …
INTRODUCTION: Alexander disease is a disorder caused by a mutation and accumulation of the glial fibrillary acidic protein. .. …
Prediction of clinical progression in nervous system diseases: plasma glial fibrillary acidic protein (GFAP).
Zheng X, Yang J, Hou Y, Shi X, Liu K. Zheng X, et al. Eur J Med Res. 2024 Jan 12;29(1):51. doi: 10.1186/s40001-023-01631-4. Eur J Med Res. 2024. PMID: 38216970 Free PMC article. Review.
Recently, observational studies revealed that cerebrospinal fluid (CSF) GFAP, as a valuable potential diagnostic biomarker for neurosyphilis, had a sensitivity of 76.60% and specificity of 85.56%. The reason plasma GFAP could serve as a promising biomarker for diagnosis an …
Recently, observational studies revealed that cerebrospinal fluid (CSF) GFAP, as a valuable potential diagnostic biomarker for neuros …
GFAP mutations in Alexander disease.
Li R, Messing A, Goldman JE, Brenner M. Li R, et al. Int J Dev Neurosci. 2002 Jun-Aug;20(3-5):259-68. doi: 10.1016/s0736-5748(02)00019-9. Int J Dev Neurosci. 2002. PMID: 12175861 Review.
Alexander disease is a rare but often fatal disease of the central nervous system. ...Thus, Alexander disease likely results from a dominant gain of function. ...
Alexander disease is a rare but often fatal disease of the central nervous system. ...Thus, Alexander disease li …
Effects of Alexander disease-associated mutations on the assembly and organization of GFAP intermediate filaments.
Yang AW, Lin NH, Yeh TH, Snider N, Perng MD. Yang AW, et al. Mol Biol Cell. 2022 Jul 1;33(8):ar69. doi: 10.1091/mbc.E22-01-0013. Epub 2022 May 5. Mol Biol Cell. 2022. PMID: 35511821 Free PMC article.
Alexander disease is a primary genetic disorder of astrocytes caused by dominant mutations in the gene encoding glial fibrillary acidic protein (GFAP). ...When transduced into primary astrocytes, GFAP mutants with in vitro assembly defects usually formed cytoplasmic …
Alexander disease is a primary genetic disorder of astrocytes caused by dominant mutations in the gene encoding glial fibrilla …
Acquisition and Loss of Developmental Milestones and Time to Disease-Related Outcomes in Cerebral Alexander Disease.
Joung J, Gallison K, Sollee JJ, Vigilante N, Cooper H, Liu GW, Ballester L, Faig W, Waldman AT. Joung J, et al. J Child Neurol. 2023 Dec;38(13-14):672-678. doi: 10.1177/08830738231210040. Epub 2023 Nov 3. J Child Neurol. 2023. PMID: 37920915
Objective: To determine the ages at acquisition of developmental milestones, loss of motor function, and clinical symptoms in Alexander disease. Methods: Patients with confirmed cerebral Alexander disease were included. ...Clinicians should have a high …
Objective: To determine the ages at acquisition of developmental milestones, loss of motor function, and clinical symptoms in Alexander …
Adult-onset Alexander disease: a series of eleven unrelated cases with review of the literature.
Pareyson D, Fancellu R, Mariotti C, Romano S, Salmaggi A, Carella F, Girotti F, Gattellaro G, Carriero MR, Farina L, Ceccherini I, Savoiardo M. Pareyson D, et al. Brain. 2008 Sep;131(Pt 9):2321-31. doi: 10.1093/brain/awn178. Epub 2008 Aug 6. Brain. 2008. PMID: 18684770 Review.
Alexander disease (AD) in its typical form is an infantile lethal leucodystrophy, characterized pathologically by Rosenthal fibre accumulation. ...We report detailed clinical and genetic data of 11 cases of AOAD, observed over a 4-year period, and a review of …
Alexander disease (AD) in its typical form is an infantile lethal leucodystrophy, characterized pathologically by Rosenthal fi …
69 results