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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1993 3
1994 1
1995 1
1996 2
1997 2
1999 1
2000 1
2002 2
2008 4
2009 2
2010 1
2011 1
2018 1
2019 1
2024 0

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22 results

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Page 1
Aminoglycoside-induced deafness during treatment of acute leukaemia.
Bitner-Glindzicz M, Osei-Lah V, Colvin I, Sirimanna T, Lucas D, Mac Ardle B, Webb D, Shankar A, Kingston J, Jenkins L, Rahman S. Bitner-Glindzicz M, et al. Arch Dis Child. 2010 Feb;95(2):153-5. doi: 10.1136/adc.2009.158220. Arch Dis Child. 2010. PMID: 20172897
Mitochondrial ribosomal RNA mutation associated with both antibiotic-induced and non-syndromic deafness.
Prezant TR, Agapian JV, Bohlman MC, Bu X, Oztas S, Qiu WQ, Arnos KS, Cortopassi GA, Jaber L, Rotter JI, et al. Prezant TR, et al. Nat Genet. 1993 Jul;4(3):289-94. doi: 10.1038/ng0793-289. Nat Genet. 1993. PMID: 7689389
Because of the known action of aminoglycosides on bacterial ribosomes, we analysed the sequence of the mitochondrial rRNA genes of three unrelated patients with familial aminoglycoside-induced deafness. We also sequenced the complete mitochondrial genome of t …
Because of the known action of aminoglycosides on bacterial ribosomes, we analysed the sequence of the mitochondrial rRNA genes of three unr …
Mitochondrial tRNAThr G15927A mutation may modulate the phenotypic manifestation of ototoxic 12S rRNA A1555G mutation in four Chinese families.
Wang X, Lu J, Zhu Y, Yang A, Yang L, Li R, Chen B, Qian Y, Tang X, Wang J, Zhang X, Guan MX. Wang X, et al. Pharmacogenet Genomics. 2008 Dec;18(12):1059-70. doi: 10.1097/FPC.0b013e3283131661. Pharmacogenet Genomics. 2008. PMID: 18820594 Free PMC article.
OBJECTIVE: To investigate the role of mitochondrial modifiers in the development of deafness associated with 12S rRNA A1555G mutation. METHODS: Four Chinese families with nonsyndromic and aminoglycoside-induced deafness were studied by clinical and gen …
OBJECTIVE: To investigate the role of mitochondrial modifiers in the development of deafness associated with 12S rRNA A1555G mutation. METHO …
Audiological and genetic features of the mtDNA mutations.
Liu XZ, Angeli S, Ouyang XM, Liu W, Ke XM, Liu YH, Liu SX, Du LL, Deng XW, Yuan H, Yan D. Liu XZ, et al. Acta Otolaryngol. 2008 Jul;128(7):732-8. doi: 10.1080/00016480701719011. Acta Otolaryngol. 2008. PMID: 18568513 Free PMC article.
The identification of the mtDNA A1555G mutation in a large proportion of Chinese probands with nonsyndromic sensorineural hearing loss (NSHL) provides a molecular explanation for the high prevalence of aminoglycoside-induced deafness in China. OBJECTIVE: The …
The identification of the mtDNA A1555G mutation in a large proportion of Chinese probands with nonsyndromic sensorineural hearing loss (NSHL …
A molecular basis for human hypersensitivity to aminoglycoside antibiotics.
Hutchin T, Haworth I, Higashi K, Fischel-Ghodsian N, Stoneking M, Saha N, Arnos C, Cortopassi G. Hutchin T, et al. Nucleic Acids Res. 1993 Sep 11;21(18):4174-9. doi: 10.1093/nar/21.18.4174. Nucleic Acids Res. 1993. PMID: 8414970 Free PMC article.
We have investigated the distribution of mitochondrial DNA polymorphisms in a rare maternally transmitted genetic trait that causes hypersensitivity to aminoglycoside antibiotics, in the hope that a characterization of its molecular basis might provide a molecular and cellular un …
We have investigated the distribution of mitochondrial DNA polymorphisms in a rare maternally transmitted genetic trait that causes hypersen …
Mitochondrial gene mutation is a significant predisposing factor in aminoglycoside ototoxicity.
Fischel-Ghodsian N, Prezant TR, Chaltraw WE, Wendt KA, Nelson RA, Arnos KS, Falk RE. Fischel-Ghodsian N, et al. Am J Otolaryngol. 1997 May-Jun;18(3):173-8. doi: 10.1016/s0196-0709(97)90078-8. Am J Otolaryngol. 1997. PMID: 9164619
PURPOSE: Aminoglycoside-induced deafness caused by mutations in the mitochondrial 12S ribosomal RNA gene has been described in a number of Asian patients. The purpose of the current study is to analyze ethnically diverse patients in the United States with hea …
PURPOSE: Aminoglycoside-induced deafness caused by mutations in the mitochondrial 12S ribosomal RNA gene has been descr …
Genetic analysis of interactions with eukaryotic rRNA identify the mitoribosome as target in aminoglycoside ototoxicity.
Hobbie SN, Akshay S, Kalapala SK, Bruell CM, Shcherbakov D, Böttger EC. Hobbie SN, et al. Proc Natl Acad Sci U S A. 2008 Dec 30;105(52):20888-93. doi: 10.1073/pnas.0811258106. Epub 2008 Dec 22. Proc Natl Acad Sci U S A. 2008. PMID: 19104050 Free PMC article.
We propose a pathogenic mechanism in which interference of aminoglycosides with mitochondrial protein synthesis exacerbates the drugs' cochlear toxicity, playing a key role in sporadic dose-dependent and genetically inherited, aminoglycoside-induced deafness. …
We propose a pathogenic mechanism in which interference of aminoglycosides with mitochondrial protein synthesis exacerbates the drugs' cochl …
22 results