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Quoted phrase not found in phrase index: "Amyotrophic lateral sclerosis type 15"
Page 1
ISG15 and ISGylation in Human Diseases.
Mirzalieva O, Juncker M, Schwartzenburg J, Desai S. Mirzalieva O, et al. Cells. 2022 Feb 4;11(3):538. doi: 10.3390/cells11030538. Cells. 2022. PMID: 35159348 Free PMC article. Review.
Type I Interferons (IFNs) induce the expression of >500 genes, which are collectively called ISGs (IFN-stimulated genes). ...However, its IFN-dependent expression is aberrantly elevated or compromised in various human diseases, including multiple types of cancer, neurod …
Type I Interferons (IFNs) induce the expression of >500 genes, which are collectively called ISGs (IFN-stimulated genes). ...Howev …
Multisite chronic pain and the risk of autoimmune diseases: A Mendelian randomization study.
Tang Y, Liu W, Kong W, Zhang S, Zhu T. Tang Y, et al. Front Immunol. 2023 Feb 9;14:1077088. doi: 10.3389/fimmu.2023.1077088. eCollection 2023. Front Immunol. 2023. PMID: 36845101 Free PMC article.
METHODS: We assessed genome-wide association study (GWAS) summary statistics for chronic pain [multisite chronic pain (MCP) and chronic widespread pain (CWP)], and eight common AIDs, namely, amyotrophic lateral sclerosis (ALS), celiac disease (CeD), inflammat …
METHODS: We assessed genome-wide association study (GWAS) summary statistics for chronic pain [multisite chronic pain (MCP) and chronic wide …
Long-Term Mechanical Insufflation-Exsufflation Cough Assistance in Neuromuscular Disease: Patterns of Use and Lessons for Application.
Chatwin M, Simonds AK. Chatwin M, et al. Respir Care. 2020 Feb;65(2):135-143. doi: 10.4187/respcare.06882. Epub 2019 Nov 5. Respir Care. 2020. PMID: 31690614 Free article.
Duchenne muscular dystrophy (DMD), spinal muscular atrophy (SMA), and amyotrophic lateral sclerosis (ALS) were the 3 most common diagnoses. ...Median (IQR) usage for the group was 60% (13.5-100%) of days for the total days. Subjects with tracheostomies or SMA …
Duchenne muscular dystrophy (DMD), spinal muscular atrophy (SMA), and amyotrophic lateral sclerosis (ALS) were the 3 mo …
Biomarkers in Neurodegenerative Diseases.
Jeromin A, Bowser R. Jeromin A, et al. Adv Neurobiol. 2017;15:491-528. doi: 10.1007/978-3-319-57193-5_20. Adv Neurobiol. 2017. PMID: 28674995 Review.
The past decade has seen tremendous efforts in biomarker discovery and validation for neurodegenerative diseases. The source and type of biomarkers has continued to grow for central nervous system diseases, from biofluid-based biomarkers (blood or cerebrospinal fluid (CSF) …
The past decade has seen tremendous efforts in biomarker discovery and validation for neurodegenerative diseases. The source and type …
Altered perivascular fibroblast activity precedes ALS disease onset.
Månberg A, Skene N, Sanders F, Trusohamn M, Remnestål J, Szczepińska A, Aksoylu IS, Lönnerberg P, Ebarasi L, Wouters S, Lehmann M, Olofsson J, von Gohren Antequera I, Domaniku A, De Schaepdryver M, De Vocht J, Poesen K, Uhlén M, Anink J, Mijnsbergen C, Vergunst-Bosch H, Hübers A, Kläppe U, Rodriguez-Vieitez E, Gilthorpe JD, Hedlund E, Harris RA, Aronica E, Van Damme P, Ludolph A, Veldink J, Ingre C, Nilsson P, Lewandowski SA. Månberg A, et al. Nat Med. 2021 Apr;27(4):640-646. doi: 10.1038/s41591-021-01295-9. Epub 2021 Apr 15. Nat Med. 2021. PMID: 33859435 Free PMC article.
Apart from well-defined factors in neuronal cells(1), only a few reports consider that the variability of sporadic amyotrophic lateral sclerosis (ALS) progression can depend on less-defined contributions from glia(2,3) and blood vessels(4). In this study we u …
Apart from well-defined factors in neuronal cells(1), only a few reports consider that the variability of sporadic amyotrophic lat …
Myofiber Type Shift in Extraocular Muscles in Amyotrophic Lateral Sclerosis.
Behzadi A, Tjust AE, Liu JX, Andersen PM, Brännström T, Pedrosa Domellöf F. Behzadi A, et al. Invest Ophthalmol Vis Sci. 2023 May 1;64(5):15. doi: 10.1167/iovs.64.5.15. Invest Ophthalmol Vis Sci. 2023. PMID: 37200039 Free PMC article.
PURPOSE: To investigate changes in myofiber composition in the global layer (GL) and orbital layer (OL) of extraocular muscles (EOMs) from terminal amyotrophic lateral sclerosis (ALS) donors. METHODS: Medial recti muscles collected postmortem from spinal-onse …
PURPOSE: To investigate changes in myofiber composition in the global layer (GL) and orbital layer (OL) of extraocular muscles (EOMs) from t …
Antisense oligonucleotide targeting DMPK in patients with myotonic dystrophy type 1: a multicentre, randomised, dose-escalation, placebo-controlled, phase 1/2a trial.
Thornton CA, Moxley RT 3rd, Eichinger K, Heatwole C, Mignon L, Arnold WD, Ashizawa T, Day JW, Dent G, Tanner MK, Duong T, Greene EP, Herbelin L, Johnson NE, King W, Kissel JT, Leung DG, Lott DJ, Norris DA, Pucillo EM, Schell W, Statland JM, Stinson N, Subramony SH, Xia S, Bishop KM, Bennett CF. Thornton CA, et al. Lancet Neurol. 2023 Mar;22(3):218-228. doi: 10.1016/S1474-4422(23)00001-7. Lancet Neurol. 2023. PMID: 36804094 Clinical Trial.
BACKGROUND: Myotonic dystrophy type 1 results from an RNA gain-of-function mutation, in which DM1 protein kinase (DMPK) transcripts carrying expanded trinucleotide repeats exert deleterious effects. ...However, skeletal muscle drug concentrations were below levels predi …
BACKGROUND: Myotonic dystrophy type 1 results from an RNA gain-of-function mutation, in which DM1 protein kinase (DMPK) transcripts c …
Clinical and Genetic Aspects of Juvenile Amyotrophic Lateral Sclerosis: A Promising Era Emerges.
Souza PVS, Serrano PL, Farias IB, Machado RIL, Badia BML, Oliveira HB, Barbosa AS, Pereira CA, Moreira VF, Chieia MAT, Barbosa AR, Braga VL, Pinto WBVR, Oliveira ASB. Souza PVS, et al. Genes (Basel). 2024 Feb 28;15(3):311. doi: 10.3390/genes15030311. Genes (Basel). 2024. PMID: 38540369 Free PMC article. Review.
More than 20 different genetic loci have been associated with both sporadic and familial juvenile Amyotrophic Lateral Sclerosis. Currently, almost 40% of cases have an identifiable monogenic basis; type 6, associated with FUS gene variants, is the most …
More than 20 different genetic loci have been associated with both sporadic and familial juvenile Amyotrophic Lateral Scler …
Malnutrition at diagnosis in amyotrophic lateral sclerosis (als) and its influence on survival: Using glim criteria.
López-Gómez JJ, Ballesteros-Pomar MD, Torres-Torres B, De la Maza BP, Penacho-Lázaro MÁ, Palacio-Mures JM, Abreu-Padín C, López-Guzmán A, De Luis-Román DA. López-Gómez JJ, et al. Clin Nutr. 2021 Jan;40(1):237-244. doi: 10.1016/j.clnu.2020.05.014. Epub 2020 May 21. Clin Nutr. 2021. PMID: 32507583
BACKGROUND: Malnutrition is a prognostic factor in Amyotrophic Lateral Sclerosis (ALS). Sometimes, this condition is underdiagnosed, and it might influence on disease progression. AIMS: To evaluate a) nutritional status at the beginning of specialized …
BACKGROUND: Malnutrition is a prognostic factor in Amyotrophic Lateral Sclerosis (ALS). Sometimes, this conditio …
Studies of Genetic and Proteomic Risk Factors of Amyotrophic Lateral Sclerosis Inspire Biomarker Development and Gene Therapy.
Bagyinszky E, Hulme J, An SSA. Bagyinszky E, et al. Cells. 2023 Jul 27;12(15):1948. doi: 10.3390/cells12151948. Cells. 2023. PMID: 37566027 Free PMC article. Review.
Amyotrophic lateral sclerosis (ALS) is an incurable neurodegenerative disease affecting the upper and lower motor neurons, leading to muscle weakness, motor impairments, disabilities and death. ...So far, there is no effective therapy against ALS. Thus, early …
Amyotrophic lateral sclerosis (ALS) is an incurable neurodegenerative disease affecting the upper and lower motor neuro …
43 results