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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
2004 1
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2014 3
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17 results

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Filters applied: Meta-Analysis, Review, Systematic Review, in the last 10 years. Clear all
Quoted phrase not found in phrase index: "Androgen backdoor pathway"
Page 1
Roles for the backdoor pathway of androgen metabolism in prostate cancer response to castration and drug treatment.
Fiandalo MV, Wilton J, Mohler JL. Fiandalo MV, et al. Int J Biol Sci. 2014 Jun 3;10(6):596-601. doi: 10.7150/ijbs.8780. eCollection 2014. Int J Biol Sci. 2014. PMID: 24948872 Free PMC article. Review.
Almost all men who present with advanced prostate cancer (CaP) and many men who fail potentially curative therapy are treated with androgen deprivation therapy (ADT). ADT is not curative and CaP recurs as the lethal phenotype. The goal of this review is to describe the evo …
Almost all men who present with advanced prostate cancer (CaP) and many men who fail potentially curative therapy are treated with androg …
Non-Classic Disorder of Adrenal Steroidogenesis and Clinical Dilemmas in 21-Hydroxylase Deficiency Combined with Backdoor Androgen Pathway. Mini-Review and Case Report.
Sumińska M, Bogusz-Górna K, Wegner D, Fichna M. Sumińska M, et al. Int J Mol Sci. 2020 Jun 29;21(13):4622. doi: 10.3390/ijms21134622. Int J Mol Sci. 2020. PMID: 32610579 Free PMC article. Review.
Up to 95% cases of CAH are due to mutations in CYP21A2 gene and subsequent 21alpha-hydroxylase deficiency, characterized by impaired cortisol synthesis and adrenal androgen excess. In the past two decades an alternative ("backdoor") pathway of androgens …
Up to 95% cases of CAH are due to mutations in CYP21A2 gene and subsequent 21alpha-hydroxylase deficiency, characterized by impaired cortiso …
Update on adrenarche.
Witchel SF, Pinto B, Burghard AC, Oberfield SE. Witchel SF, et al. Curr Opin Pediatr. 2020 Aug;32(4):574-581. doi: 10.1097/MOP.0000000000000928. Curr Opin Pediatr. 2020. PMID: 32692055 Free PMC article. Review.
RECENT FINDINGS: The complexity of adrenal steroidogenesis has increased with recognition of the alternative 'backdoor pathway' and the 11-oxo-androgens pathways. Traditionally, sulfated steroids such as DHEAS have been considered to be inactive metabo …
RECENT FINDINGS: The complexity of adrenal steroidogenesis has increased with recognition of the alternative 'backdoor pathway …
Steroidogenesis in castration-resistant prostate cancer.
Shiota M, Endo S, Blas L, Fujimoto N, Eto M. Shiota M, et al. Urol Oncol. 2023 May;41(5):240-251. doi: 10.1016/j.urolonc.2022.10.018. Epub 2022 Nov 11. Urol Oncol. 2023. PMID: 36376200 Review.
In addition to the classical pathway to produce potent androgens such as testosterone and dihydrotestosterone, the alternative pathway and the backdoor pathway which bypasses testosterone to produce dihydrotestosterone have been shown to play a …
In addition to the classical pathway to produce potent androgens such as testosterone and dihydrotestosterone, the alternative …
Concept and viability of androgen annihilation for advanced prostate cancer.
Mohler JL. Mohler JL. Cancer. 2014 Sep 1;120(17):2628-37. doi: 10.1002/cncr.28675. Epub 2014 Apr 25. Cancer. 2014. PMID: 24771515 Free PMC article. Review.
ADT may be more effective when initiated for minimal disease burden, which can be detected using PSA after radical prostatectomy or radiotherapy, and if more complete disruption of the androgen axis using newer agents decreases the chance that androgen-sensitive cel …
ADT may be more effective when initiated for minimal disease burden, which can be detected using PSA after radical prostatectomy or radiothe …
Androgens in Congenital Adrenal Hyperplasia.
Pignatelli D, Pereira SS, Pasquali R. Pignatelli D, et al. Front Horm Res. 2019;53:65-76. doi: 10.1159/000494903. Epub 2019 Sep 9. Front Horm Res. 2019. PMID: 31499506 Review.
This disease is generally associated with elevated secretion of androgens, sometimes resulting in virilizing syndromes, including genital ambiguity, precocious puberty in both sexes, or milder syndromes of androgen excess like precocious pubarche or the occurrence o …
This disease is generally associated with elevated secretion of androgens, sometimes resulting in virilizing syndromes, including gen …
Androgens and the masculinization programming window: human-rodent differences.
Sharpe RM. Sharpe RM. Biochem Soc Trans. 2020 Aug 28;48(4):1725-1735. doi: 10.1042/BST20200200. Biochem Soc Trans. 2020. PMID: 32779695 Free PMC article. Review.
AGD thus provides a lifelong, calibrated readout of MPW androgen exposure and predicts likelihood of reproductive dysfunction. ...In fetal human testis culture/xenografts, DEHP/DBP do not reduce testosterone production, whereas therapeutic paracetamol exposure does. In hum …
AGD thus provides a lifelong, calibrated readout of MPW androgen exposure and predicts likelihood of reproductive dysfunction. ...In …
Canonical and Noncanonical Androgen Metabolism and Activity.
Storbeck KH, Mostaghel EA. Storbeck KH, et al. Adv Exp Med Biol. 2019;1210:239-277. doi: 10.1007/978-3-030-32656-2_11. Adv Exp Med Biol. 2019. PMID: 31900912 Review.
Androgens are critical drivers of prostate cancer. In this chapter we first discuss the canonical pathways of androgen metabolism and their alterations in prostate cancer progression, including the classical, backdoor and 5alpha-dione pathways, …
Androgens are critical drivers of prostate cancer. In this chapter we first discuss the canonical pathways of androgen …
Potential impact of combined inhibition of 3α-oxidoreductases and 5α-reductases on prostate cancer.
Fiandalo MV, Gewirth DT, Mohler JL. Fiandalo MV, et al. Asian J Urol. 2019 Jan;6(1):50-56. doi: 10.1016/j.ajur.2018.09.002. Epub 2018 Sep 26. Asian J Urol. 2019. PMID: 30775248 Free PMC article. Review.
One mechanism for PCa recurrence relies on intratumoral synthesis of DHT, which can be synthesized using the frontdoor or primary or secondary backdoor pathway. Androgen metabolism inhibitors, such as those targeting 5alpha-reductase, aldo-keto-reductase fami …
One mechanism for PCa recurrence relies on intratumoral synthesis of DHT, which can be synthesized using the frontdoor or primary or seconda …
Regulation of human (adrenal) androgen biosynthesis-New insights from novel throughput technology studies.
Udhane SS, Flück CE. Udhane SS, et al. Biochem Pharmacol. 2016 Feb 15;102:20-33. doi: 10.1016/j.bcp.2015.10.010. Epub 2015 Oct 20. Biochem Pharmacol. 2016. PMID: 26498719 Review.
Here, the knowledge on human androgen biosynthesis and regulation is reviewed with a special focus on human adrenal androgen production and the hyperandrogenic disorder of polycystic ovary syndrome (PCOS). ...Similarly, transcriptome analysis of human adrenal NCI-H2 …
Here, the knowledge on human androgen biosynthesis and regulation is reviewed with a special focus on human adrenal androgen p …
17 results