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Page 1
Clomiphene citrate for men with hypogonadism: a systematic review and meta-analysis.
Huijben M, Lock MTWT, de Kemp VF, de Kort LMO, van Breda HMK. Huijben M, et al. Andrology. 2022 Mar;10(3):451-469. doi: 10.1111/andr.13146. Epub 2022 Jan 8. Andrology. 2022. PMID: 34933414 Free article. Review.
BACKGROUND: Male hypogonadism is a clinical and biochemical androgen insufficiency syndrome, becoming more prevalent with age. ...RESULTS: We included 19 studies, comprising four randomized controlled trials and 15 observational studies, resulting in 1642 pat …
BACKGROUND: Male hypogonadism is a clinical and biochemical androgen insufficiency syndrome, becoming more prevalent with age. …
Androgen in postmenopausal women.
Yasui T, Matsui S, Tani A, Kunimi K, Yamamoto S, Irahara M. Yasui T, et al. J Med Invest. 2012;59(1-2):12-27. doi: 10.2152/jmi.59.12. J Med Invest. 2012. PMID: 22449989 Free article. Review.
Circulating levels of testosterone and dehydroepiandrosterone sulfate (DHEA-S) gradually decrease with age in postmenopausal women, although transient increases have been observed during the menopausal transition. High testosterone level has been suggested to be associated …
Circulating levels of testosterone and dehydroepiandrosterone sulfate (DHEA-S) gradually decrease with age in postmenopausal women, although …
Are androgens critical for penile erections in humans? Examining the clinical and preclinical evidence.
Traish AM, Guay AT. Traish AM, et al. J Sex Med. 2006 May;3(3):382-404; discussion 404-7. doi: 10.1111/j.1743-6109.2006.00245.x. J Sex Med. 2006. PMID: 16681465 Review.
In contrast to animals, especially rodents in which the adrenal cortex does not synthesize androgens, the human adrenal is a source of peripherally circulating androgen precursors, thus, complete androgen insufficiency may not be observed in men at a younger …
In contrast to animals, especially rodents in which the adrenal cortex does not synthesize androgens, the human adrenal is a source of perip …
Osteoporosis: diagnosis and management today and tomorrow.
Christiansen C. Christiansen C. Bone. 1995 Nov;17(5 Suppl):513S-516S. doi: 10.1016/8756-3282(95)00345-0. Bone. 1995. PMID: 8573429 Review.
The major cause of osteoporosis is estrogen withdrawal in women, most commonly associated with the menopause, but also with other causes of ovarian failure. Androgen insufficiency in men, although much less common, can also lead to osteoporosis. Measurements of bone …
The major cause of osteoporosis is estrogen withdrawal in women, most commonly associated with the menopause, but also with other causes of …
Turbulent times for hormone replacement therapy: is there a way out?
Verhaeghe J. Verhaeghe J. Gynecol Obstet Invest. 2003;56(1):43-50. doi: 10.1159/000072483. Epub 2003 Jul 22. Gynecol Obstet Invest. 2003. PMID: 12876424 Free article. Review.
The long-awaited results of the large Women's Health Initiative (WHI) trial on the effects of combined estrogen-progestin hormone replacement therapy (HRT) in postmenopausal women show that the overall benefits are smaller than the risks. Herein I argue that many of the findings …
The long-awaited results of the large Women's Health Initiative (WHI) trial on the effects of combined estrogen-progestin hormone replacemen …
The Association of Reproductive Hormone Levels and All-Cause, Cancer, and Cardiovascular Disease Mortality in Men.
Holmboe SA, Vradi E, Jensen TK, Linneberg A, Husemoen LL, Scheike T, Skakkebæk NE, Juul A, Andersson AM. Holmboe SA, et al. J Clin Endocrinol Metab. 2015 Dec;100(12):4472-80. doi: 10.1210/jc.2015-2460. Epub 2015 Oct 21. J Clin Endocrinol Metab. 2015. PMID: 26488309
Furthermore, negative trends were seen for SHBG and free T in relation to CVD mortality, however insignificant. CONCLUSION: The observed positive association of LH and LH/T, but not T, with all-cause mortality suggests that a compensated impaired Leydig cell function may b …
Furthermore, negative trends were seen for SHBG and free T in relation to CVD mortality, however insignificant. CONCLUSION: The observed
Age-dependent differences in androgen binding affinity in a family with spinal and bulbar muscular atrophy.
MacLean HE, Gonzales M, Greenland KJ, Warne GL, Zajac JD. MacLean HE, et al. Neurol Res. 2005 Jul;27(5):548-51. doi: 10.1179/016164105X39851. Neurol Res. 2005. PMID: 15978183
Post-mortem analysis in one subject confirmed the signs of androgen insufficiency in the testis, with marked seminiferous tubule atrophy, and the absence of germinal cells. The characteristic neuronal depletion in the anterior horn gray matter was also observed
Post-mortem analysis in one subject confirmed the signs of androgen insufficiency in the testis, with marked seminiferous tubu …
Comparative effects of oral esterified estrogens with and without methyltestosterone on endocrine profiles and dimensions of sexual function in postmenopausal women with hypoactive sexual desire.
Lobo RA, Rosen RC, Yang HM, Block B, Van Der Hoop RG. Lobo RA, et al. Fertil Steril. 2003 Jun;79(6):1341-52. doi: 10.1016/s0015-0282(03)00358-3. Fertil Steril. 2003. PMID: 12798881 Free article. Clinical Trial.
OBJECTIVE: In some women, a decline in sexual interest accompanies a relative androgen insufficiency after menopause. We sought to characterize the hormonal effects of the combination of oral esterified estrogens and methyltestosterone and to investigate whether thi …
OBJECTIVE: In some women, a decline in sexual interest accompanies a relative androgen insufficiency after menopause. We sough …