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GM-CSF contributes to aortic aneurysms resulting from SMAD3 deficiency.
Ye P, Chen W, Wu J, Huang X, Li J, Wang S, Liu Z, Wang G, Yang X, Zhang P, Lv Q, Xia J. Ye P, et al. J Clin Invest. 2013 May;123(5):2317-31. doi: 10.1172/JCI67356. Epub 2013 Apr 15. J Clin Invest. 2013. PMID: 23585475 Free PMC article.
Heterozygous loss-of-function SMAD3 (Mothers against decapentaplegic homolog 3) mutations lead to aneurysm-osteoarthritis syndrome (AOS). In the present study, we found that mice lacking Smad3 had a vascular phenotype similar to AOS, marked by the progressive …
Heterozygous loss-of-function SMAD3 (Mothers against decapentaplegic homolog 3) mutations lead to aneurysm-osteoarthritis s …
SMAD3 is associated with the total burden of radiographic osteoarthritis: the Chingford study.
Aref-Eshghi E, Zhang Y, Hart D, Valdes AM, Furey A, Martin G, Sun G, Rahman P, Arden N, Spector TD, Zhai G. Aref-Eshghi E, et al. PLoS One. 2014 May 22;9(5):e97786. doi: 10.1371/journal.pone.0097786. eCollection 2014. PLoS One. 2014. PMID: 24852296 Free PMC article.
BACKGROUND: A newly-described syndrome called Aneurysm-Osteoarthritis Syndrome (AOS) was recently reported. AOS presents with early onset osteoarthritis (OA) in multiple joints, together with aneurysms in major arteries, and is caused by rare mutations in SMA …
BACKGROUND: A newly-described syndrome called Aneurysm-Osteoarthritis Syndrome (AOS) was recently reported. AOS present …