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1975 1
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1979 4
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1985 3
1986 2
1987 2
1988 3
1989 5
1990 1
1991 2
1993 5
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Page 1
Anordrin Eliminates Tamoxifen Side Effects without Changing Its Antitumor Activity.
Gu W, Xu W, Sun X, Zeng B, Wang S, Dong N, Zhang X, Chen C, Yang L, Chen G, Xin A, Ni Z, Wang J, Yang J. Gu W, et al. Sci Rep. 2017 Mar 7;7:43940. doi: 10.1038/srep43940. Sci Rep. 2017. PMID: 28266626 Free PMC article.
Additionally, compared with tamoxifen, anordiol, the active metabolite of anordrin, weakly bound to the ligand binding domain of ER-alpha. Anordrin did not regulate the classic estrogen nuclear pathway; thus, it did not affect the anti-tumor activity of tamoxifen in …
Additionally, compared with tamoxifen, anordiol, the active metabolite of anordrin, weakly bound to the ligand binding domain of ER-a …
Effects of anordrin and its analogue on antifertility.
Liu CQ, Chen BL, Shen SR, Zhang GZ, Dai MZ. Liu CQ, et al. Contraception. 1985 Sep;32(3):301-9. doi: 10.1016/0010-7824(85)90053-8. Contraception. 1985. PMID: 3841308
Anordrin has been used as an effective postcoital contraceptive in China. ...This study warrants that anordrin should been evaluated further....
Anordrin has been used as an effective postcoital contraceptive in China. ...This study warrants that anordrin should been eva …
Pharmacokinetics and pharmacodynamics of anordrin (2 alpha, 17 alpha-diethynyl-A-nor-5 alpha-androstane-2 beta, 17 beta-diol diproprionate).
Chatterton RT Jr, Kowalski W, Lu YC, Peters AJ. Chatterton RT Jr, et al. Steroids. 1994 Mar;59(3):217-23. doi: 10.1016/0039-128x(94)90031-0. Steroids. 1994. PMID: 8048155
In order to determine the pharmacokinetics of anordrin a dose of 0.2 mg/kg of [3-14 C]anordrin was administered i.v. to 5 cynomolgus monkeys; the same monkeys received the same dose i.m. at a later date. ...After i.v. administration, anordrin had a mean resid …
In order to determine the pharmacokinetics of anordrin a dose of 0.2 mg/kg of [3-14 C]anordrin was administered i.v. to 5 cyno …
Predominant contributions of carboxylesterase 1 and 2 in hydrolysis of anordrin in humans.
Jiang J, Chen X, Zhong D. Jiang J, et al. Xenobiotica. 2018 May;48(5):533-540. doi: 10.1080/00498254.2017.1333658. Epub 2017 Jun 7. Xenobiotica. 2018. PMID: 28532270
This study aims to elucidate enzymes involved in anordrin hydrolysis, and to evaluate the significant role of carboxylesterases in anordrin hydrolysis in humans. 2. ...The present study investigated for the first time hydrolytic enzyme phenotypes of anordrin. …
This study aims to elucidate enzymes involved in anordrin hydrolysis, and to evaluate the significant role of carboxylesterases in …
Postcoital contraception.
[No authors listed] [No authors listed] Lancet. 1983 Apr 16;1(8329):855-6. Lancet. 1983. PMID: 6132182
Quingestanol has been used as a continuing postcoital agent in Latin America but proved unacceptable owing to nausea and irregular bleeding. In China "visiting pills" have been devised containing anordrin. In the West regimens of this sort have been superseded by the Yuzpe …
Quingestanol has been used as a continuing postcoital agent in Latin America but proved unacceptable owing to nausea and irregular bleeding. …
Additive effect of RU 486 and anordrin on pregnancy interruption in the mouse.
Forcelledo ML, Cardenas H, Croxatto HB. Forcelledo ML, et al. Contraception. 1993 Mar;47(3):317-23. doi: 10.1016/0010-7824(93)90048-c. Contraception. 1993. PMID: 8462321
Serum P was normal at 24 h but fell significantly 48 h after treatment with anordrin (0.05 mg). Doses of 0.05 or 0.2 mg anordrin were effective in interrupting pregnancy in 30% and 70% of pregnant mice, respectively. ...The combination of small doses of anordrin …
Serum P was normal at 24 h but fell significantly 48 h after treatment with anordrin (0.05 mg). Doses of 0.05 or 0.2 mg anordrin …
Termination of early pregnancy in the rat, rabbit, and hamster with RU 486 and anordrin.
Chang CC, Wang WC, Bardin CW. Chang CC, et al. Contraception. 1993 Jun;47(6):597-608. doi: 10.1016/0010-7824(93)90027-5. Contraception. 1993. PMID: 8334894
The effectiveness of oral RU 486 and anordrin given alone and in combination for terminating early pregnancy was tested in the rat, rabbit, and hamster. ...A non-effective dose of RU 486 combined with a non-effective or a sub-effective dose of anordrin, or a low eff …
The effectiveness of oral RU 486 and anordrin given alone and in combination for terminating early pregnancy was tested in the rat, r …
Anordiol is more potent than anordrin for terminating pregnancy when administered with RU 486.
Wang WC, Chang CC, Bardin CW. Wang WC, et al. Contraception. 1993 Jun;47(6):609-16. doi: 10.1016/0010-7824(93)90028-6. Contraception. 1993. PMID: 8334895
In view of the unexpected ability of anordrin to synergize with RU 486 in terminating pregnancy, it was pertinent to examine the actions of the dihydroxylated metabolite of anordrin, anordiol, alone and in combination with RU 486. ...This anordrin metabolite …
In view of the unexpected ability of anordrin to synergize with RU 486 in terminating pregnancy, it was pertinent to examine the acti …
Effects of anordrin, droloxifene, nomegestrol, and mifepristone on cultured rat luteal cell apoptosis.
Leng Y, Yang B, Cao L, Gu ZP. Leng Y, et al. Zhongguo Yao Li Xue Bao. 1999 May;20(5):400-4. Zhongguo Yao Li Xue Bao. 1999. PMID: 10678084 Free article.
AIM: To study the effect of four kinds of antifertility agents anordrin(Ano), droloxifene(Dro), nomegestrol (Nom), and mifepristone (Mif) on luteal cell apoptosis. ...
AIM: To study the effect of four kinds of antifertility agents anordrin(Ano), droloxifene(Dro), nomegestrol (Nom), and mifepristone ( …
Antiangiogenic effect of alpha-anordrin in vitro and in vivo.
Ma ZC, Lou LG, Zhang Z, Xu B. Ma ZC, et al. Acta Pharmacol Sin. 2000 Oct;21(10):939-44. Acta Pharmacol Sin. 2000. PMID: 11501049 Free article.
AIM: To study the antiangiogenic effect of alpha-anordrin (alpha-Ano), a partial antagonist of estrogen receptor. METHODS: The in vivo inhibitory effect of alpha-Ano on angiogenesis was determined by microvascular density (MVD) in tumors and the chicken chorioallantoic mem …
AIM: To study the antiangiogenic effect of alpha-anordrin (alpha-Ano), a partial antagonist of estrogen receptor. METHODS: The in viv …
57 results