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Aromatase and gynecomastia.
Braunstein GD. Braunstein GD. Endocr Relat Cancer. 1999 Jun;6(2):315-24. doi: 10.1677/erc.0.0060315. Endocr Relat Cancer. 1999. PMID: 10731125 Review.
Klinefelter's syndrome, and neoplasms of the testes, adrenals and liver. A primary aromatase excess syndrome with exuberant gynecomastia had been found both sporadically and in a familial setting. ...
Klinefelter's syndrome, and neoplasms of the testes, adrenals and liver. A primary aromatase excess syndrome with exube …
Aromatase inhibitors in pediatrics.
Wit JM, Hero M, Nunez SB. Wit JM, et al. Nat Rev Endocrinol. 2011 Oct 25;8(3):135-47. doi: 10.1038/nrendo.2011.161. Nat Rev Endocrinol. 2011. PMID: 22024975 Review.
The availability of the selective aromatase inhibitors letrozole and anastrozole--currently approved as adjuvant therapy for breast cancer--have stimulated off-label use of aromatase inhibitors in pediatrics for the following conditions: hyperestrogenism, such as aromatase …
The availability of the selective aromatase inhibitors letrozole and anastrozole--currently approved as adjuvant therapy for breast cancer-- …
Long-term Effect of Aromatase Inhibition in Aromatase Excess Syndrome.
Binder G, Nakamura A, Schweizer R, Ogata T, Fukami M, Nagasaki K. Binder G, et al. J Clin Endocrinol Metab. 2021 Apr 23;106(5):1491-1500. doi: 10.1210/clinem/dgab054. J Clin Endocrinol Metab. 2021. PMID: 33513243
CONTEXT: Aromatase excess syndrome (AEXS) is a very rare disorder characterized by prepubertal gynecomastia, bone age acceleration, and early growth arrest. ...
CONTEXT: Aromatase excess syndrome (AEXS) is a very rare disorder characterized by prepubertal gynecomastia, bone age a …
Aromatase excess syndrome: a rare autosomal dominant disorder leading to pre- or peri-pubertal onset gynecomastia.
Fukami M, Miyado M, Nagasaki K, Shozu M, Ogata T. Fukami M, et al. Pediatr Endocrinol Rev. 2014 Mar;11(3):298-305. Pediatr Endocrinol Rev. 2014. PMID: 24716396 Review.
Overexpression of CYP19A1 encoding aromatase results in a rare genetic disorder referred to as aromatase excess syndrome (AEXS). Male patients with AEXS manifest pre- or peri-pubertal onset gynecomastia, gonadotropin deficiency, and advanced bone age, while f …
Overexpression of CYP19A1 encoding aromatase results in a rare genetic disorder referred to as aromatase excess syndrome …
Aromatase excess syndrome in a Chinese boy due to a novel duplication at 15q21.2.
Tan X, Wu X, Chen J, Wu Y, Li S, Chen X, Zhang X. Tan X, et al. J Pediatr Endocrinol Metab. 2019 Jan 28;32(1):85-88. doi: 10.1515/jpem-2018-0266. J Pediatr Endocrinol Metab. 2019. PMID: 30530883
Background Aromatase excess syndrome (AEXS) is a rare autosomal dominant disorder caused by CYP19A1 overexpression. Clinical manifestations of AEXS include pre- or peri-pubertal gynecomastia, advanced bone age and compromised adult height. ...
Background Aromatase excess syndrome (AEXS) is a rare autosomal dominant disorder caused by CYP19A1 overexpression. …
Dominant transmission of prepubertal gynecomastia due to serum estrone excess: hormonal, biochemical, and genetic analysis in a large kindred.
Binder G, Iliev DI, Dufke A, Wabitsch M, Schweizer R, Ranke MB, Schmidt M. Binder G, et al. J Clin Endocrinol Metab. 2005 Jan;90(1):484-92. doi: 10.1210/jc.2004-1566. Epub 2004 Oct 13. J Clin Endocrinol Metab. 2005. PMID: 15483104
Excess of serum estrone in the presence of normal 17beta-estradiol levels may be the only indicative serum parameter of this mild manifestation of aromatase excess syndrome, which includes prepubertal gynecomastia and moderate hypogonadism in men but not nece …
Excess of serum estrone in the presence of normal 17beta-estradiol levels may be the only indicative serum parameter of this mild manifestat …