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Page 1
Asfotase Alfa (Strensiq).
[No authors listed] [No authors listed] Ottawa (ON): Canadian Agency for Drugs and Technologies in Health; 2017 Apr. Ottawa (ON): Canadian Agency for Drugs and Technologies in Health; 2017 Apr. PMID: 29356465 Free Books & Documents. Review.
The incidence is much higher within the Canadian Mennonite population; it has been reported to be one in every 2,500 births in Manitoba.(,) Currently, except for asfotase alfa (Strensiq), there are no approved treatments for HPP. The main stream of therapy focuses o …
The incidence is much higher within the Canadian Mennonite population; it has been reported to be one in every 2,500 births in Manitoba.(,) …
Asfotase alfa for hypophosphatasia.
[No authors listed] [No authors listed] Aust Prescr. 2018 Dec;41(6):196-197. doi: 10.18773/austprescr.2018.064. Epub 2018 Oct 18. Aust Prescr. 2018. PMID: 30670890 Free PMC article. Review. No abstract available.
Asfotase Alfa: A Review in Paediatric-Onset Hypophosphatasia.
Scott LJ. Scott LJ. Drugs. 2016 Feb;76(2):255-62. doi: 10.1007/s40265-015-0535-2. Drugs. 2016. PMID: 26744272 Review.
Furthermore, patients typically experienced improvements in respiratory function, gross motor function, fine motor function, cognitive development, muscle strength (normalization) and ability to perform activities of daily living, and catch-up height-gain. In life-threatening per …
Furthermore, patients typically experienced improvements in respiratory function, gross motor function, fine motor function, cognitive devel …
Asfotase alfa: enzyme replacement for the treatment of bone disease in hypophosphatasia.
Hofmann C, Seefried L, Jakob F. Hofmann C, et al. Drugs Today (Barc). 2016 May;52(5):271-85. doi: 10.1358/dot.2016.52.5.2482878. Drugs Today (Barc). 2016. PMID: 27376160 Review.
In childhood HPP, asfotase alfa improved growth, gross motor function, strength and agility and decreased pain. ...Further studies to evaluate risks and benefits of enzyme replacement therapy with asfotase alfa in adults are in progress and are also st …
In childhood HPP, asfotase alfa improved growth, gross motor function, strength and agility and decreased pain. ...Further stu …
Effect of Asfotase Alfa in the Treatment of Hypophosphatasia- A Systematic Review.
Jaswanthi N, Sindhu R, Nimmy P, Prabu D, RajMohan M, Bharathwaj VV, Dhamodhar D, Sathiyapriya S. Jaswanthi N, et al. J Pharm Bioallied Sci. 2023 Jul;15(Suppl 1):S101-S104. doi: 10.4103/jpbs.jpbs_662_22. Epub 2023 Jul 5. J Pharm Bioallied Sci. 2023. PMID: 37654393 Free PMC article.
Therefore, the only effective treatment for HPP is enzyme replacement therapy using the drug asfotase alfa which increases the patient's life span. The aim of the study is to evaluate the effectiveness and safety of asfotase alfa (enzyme replacement th …
Therefore, the only effective treatment for HPP is enzyme replacement therapy using the drug asfotase alfa which increases the …
Asfotase Alfa in Perinatal/Infantile-Onset and Juvenile-Onset Hypophosphatasia: A Guide to Its Use in the USA.
Scott LJ. Scott LJ. BioDrugs. 2016 Feb;30(1):41-8. doi: 10.1007/s40259-016-0161-x. BioDrugs. 2016. PMID: 26832358 Review.
In clinical trials, asfotase alfa was an effective and generally well tolerated treatment for perinatal/infantile- and juvenile onset-HPP through at least 3 and 5 years' treatment, respectively. Relative to untreated age-matched, juvenile-onset-HPP historical contro …
In clinical trials, asfotase alfa was an effective and generally well tolerated treatment for perinatal/infantile- and juvenil …
Monitoring guidance for patients with hypophosphatasia treated with asfotase alfa.
Kishnani PS, Rush ET, Arundel P, Bishop N, Dahir K, Fraser W, Harmatz P, Linglart A, Munns CF, Nunes ME, Saal HM, Seefried L, Ozono K. Kishnani PS, et al. Mol Genet Metab. 2017 Sep;122(1-2):4-17. doi: 10.1016/j.ymgme.2017.07.010. Epub 2017 Jul 25. Mol Genet Metab. 2017. PMID: 28888853 Free article. Review.
To address the unmet need for guidance in the monitoring of patients receiving asfotase alfa, an international panel of physicians with experience in diagnosing and managing HPP convened in May 2016 to discuss treatment monitoring parameters. The panel discussions f …
To address the unmet need for guidance in the monitoring of patients receiving asfotase alfa, an international panel of physic …
Interference of Asfotase Alfa in Immunoassays Employing Alkaline Phosphatase Technology.
Piec ID, Tompkins B, Fraser WD. Piec ID, et al. J Appl Lab Med. 2020 Mar 1;5(2):290-299. doi: 10.1093/jalm/jfz007. J Appl Lab Med. 2020. PMID: 32445383
RESULTS: Asfotase alfa was detected in all ALP assays but ALKP1 (RayBiotech). We observed no changes in normetanephrine and noradrenaline (IBL) at any asfotase alfa concentration. However, asfotase alfa notably interfered in an oxytocin ( …
RESULTS: Asfotase alfa was detected in all ALP assays but ALKP1 (RayBiotech). We observed no changes in normetanephrine and no …
Hypophosphatasia.
Tournis S, Yavropoulou MP, Polyzos SA, Doulgeraki A. Tournis S, et al. J Clin Med. 2021 Dec 1;10(23):5676. doi: 10.3390/jcm10235676. J Clin Med. 2021. PMID: 34884378 Free PMC article. Review.
Severe cases, with life-threating or debilitating complications, can be successfully treated with enzyme replacement therapy with asfotase alfa....
Severe cases, with life-threating or debilitating complications, can be successfully treated with enzyme replacement therapy with asfotas …
Pharmacodynamics of asfotase alfa in adults with pediatric-onset hypophosphatasia.
Seefried L, Kishnani PS, Moseley S, Denker AE, Watsky E, Whyte MP, Dahir KM. Seefried L, et al. Bone. 2021 Jan;142:115664. doi: 10.1016/j.bone.2020.115664. Epub 2020 Sep 26. Bone. 2021. PMID: 32987199 Free article. Clinical Trial.
However, there is limited information concerning the appropriate dose of asfotase alfa for adult patients with pediatric-onset HPP. Thus, we evaluated the pharmacodynamics and safety/tolerability of different doses of asfotase alfa in such patients. .. …
However, there is limited information concerning the appropriate dose of asfotase alfa for adult patients with pediatric-onset …
163 results