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Blood CD62Llow inflammatory eosinophils are related to the severity of asthma and reduced by mepolizumab.
Vultaggio A, Accinno M, Vivarelli E, Mecheri V, Maggiore G, Cosmi L, Parronchi P, Rossi O, Maggi E, Gallo O, Matucci A. Vultaggio A, et al. Allergy. 2023 Dec;78(12):3154-3165. doi: 10.1111/all.15909. Epub 2023 Oct 4. Allergy. 2023. PMID: 37792721
Blood eosinophils were analyzed by FACS and correlated with clinical scores. In vitro effect of IL-5 and mepolizumab on CD62L expression was assessed. RESULTS: A significant correlation between blood CD62L(low) cells and clinical scores of asthma and
Blood eosinophils were analyzed by FACS and correlated with clinical scores. In vitro effect of IL-5 and mepolizumab on CD62L express …
Improvement in eosinophilic esophagitis when using dupilumab for other indications or compassionate use.
Spergel BL, Ruffner MA, Godwin BC, Liacouras CA, Cianferoni A, Gober L, Hill DA, Brown-Whitehorn TF, Chaiboonma K, Aceves SA, Muir AM, Spergel JM. Spergel BL, et al. Ann Allergy Asthma Immunol. 2022 May;128(5):589-593. doi: 10.1016/j.anai.2022.01.019. Epub 2022 Jan 25. Ann Allergy Asthma Immunol. 2022. PMID: 35085819
BACKGROUND: Dupilumab has been approved to treat atopic dermatitis, asthma, and nasal polyps and is in active clinical trials for the treatment of eosinophilic esophagitis (EoE). ...METHODS: We completed a retrospective chart review of all patients at …
BACKGROUND: Dupilumab has been approved to treat atopic dermatitis, asthma, and nasal polyps and is in active cl …
Characterization and treatment of patients with chronic rhinosinusitis and nasal polyps.
Fountain CR, Mudd PA, Ramakrishnan VR, Sillau SH, Kingdom TT, Katial RK. Fountain CR, et al. Ann Allergy Asthma Immunol. 2013 Nov;111(5):337-41. doi: 10.1016/j.anai.2013.07.017. Epub 2013 Aug 20. Ann Allergy Asthma Immunol. 2013. PMID: 24125137
Data included patient demographics, asthma severity, peripheral eosinophilia, Lund-Mackay computed tomographic score, symptomatic dysosmia, and therapeutic interventions. RESULTS: Of the 182 patients included, 81 had aspirin sensitivity (45%) and 101 had aspirin tolerance …
Data included patient demographics, asthma severity, peripheral eosinophilia, Lund-Mackay computed tomographic score, symptomatic dys …
The clinical relationship of nasal polyps to asthma.
Larsen K. Larsen K. Allergy Asthma Proc. 1996 Sep-Oct;17(5):243-9. doi: 10.2500/108854196778662255. Allergy Asthma Proc. 1996. PMID: 8922143
From a meta-analysis on the clinical related literature on asthma and nasal polyps, it was found that patients with asthma had polyps in 7 to 15% with the highest frequency in the age group above 50 years. ...Most patients showed improvement or at the …
From a meta-analysis on the clinical related literature on asthma and nasal polyps, it was found that patients w …
Relationships of indoleamine 2,3-dioxygenase activity and cofactors with asthma and nasal polyps.
Luukkainen A, Karjalainen J, Hurme M, Paavonen T, Huhtala H, Toppila-Salmi S. Luukkainen A, et al. Am J Rhinol Allergy. 2014 Jan-Feb;28(1):e5-10. doi: 10.2500/ajra.2014.28.4013. Am J Rhinol Allergy. 2014. PMID: 24717869
Indoleamine 2,3-dioxygenase (IDO) is an enzyme involved in the catabolism of the essential amino acid tryptophan (Trp) to kynurenine (Kyn). Low IDO activity has been previously observed in atopy and asthma. The objective was to investigate the relationships of IDO activity …
Indoleamine 2,3-dioxygenase (IDO) is an enzyme involved in the catabolism of the essential amino acid tryptophan (Trp) to kynurenine (Kyn). …
Quality of life improvement from sinus surgery in chronic rhinosinusitis patients with asthma and nasal polyps.
Zhang Z, Adappa ND, Doghramji LJ, Chiu AG, Lautenbach E, Cohen NA, Palmer JN. Zhang Z, et al. Int Forum Allergy Rhinol. 2014 Nov;4(11):885-92. doi: 10.1002/alr.21406. Epub 2014 Sep 25. Int Forum Allergy Rhinol. 2014. PMID: 25256422
BACKGROUND: It is unclear whether chronic rhinosinusitis (CRS) patients with both nasal polyps and asthma have different quality of life (QOL) improvement after functional endoscopic sinus surgery (FESS). We aimed to determine whether CRS patients with asthma and
BACKGROUND: It is unclear whether chronic rhinosinusitis (CRS) patients with both nasal polyps and asthma have different quality of life (QO …
Effect of Subcutaneous Dupilumab on Nasal Polyp Burden in Patients With Chronic Sinusitis and Nasal Polyposis: A Randomized Clinical Trial.
Bachert C, Mannent L, Naclerio RM, Mullol J, Ferguson BJ, Gevaert P, Hellings P, Jiao L, Wang L, Evans RR, Pirozzi G, Graham NM, Swanson B, Hamilton JD, Radin A, Gandhi NA, Stahl N, Yancopoulos GD, Sutherland ER. Bachert C, et al. JAMA. 2016 Feb 2;315(5):469-79. doi: 10.1001/jama.2015.19330. JAMA. 2016. PMID: 26836729 Clinical Trial.
MAIN OUTCOMES AND MEASURES: Change in endoscopic nasal polyp score (range, 0-8; higher scores indicate worse status) at 16 weeks (primary end point). Secondary end points included Lund-Mackay computed tomography (CT) score (range, 0-24; higher scores i …
MAIN OUTCOMES AND MEASURES: Change in endoscopic nasal polyp score (range, 0-8; higher scores indicate worse status) at 16 wee …
Anti-inflammatory properties of montelukast, a leukotriene receptor antagonist in patients with asthma and nasal polyposis.
Schäper C, Noga O, Koch B, Ewert R, Felix SB, Gläser S, Kunkel G, Gustavus B. Schäper C, et al. J Investig Allergol Clin Immunol. 2011;21(1):51-8. J Investig Allergol Clin Immunol. 2011. PMID: 21370724 Free article. Clinical Trial.
OBJECTIVE: To examine the influence of the cysteinyl-leukotriene receptor antagonist montelukast on clinical symptoms and inflammatory markers in nasal lavage fluid in patients with bronchial asthma and nasal polyps, and determine its dependency on asp …
OBJECTIVE: To examine the influence of the cysteinyl-leukotriene receptor antagonist montelukast on clinical symptoms and inflammatory marke …
Longitudinal improvement and stability of olfactory function in the evaluation of surgical management for chronic rhinosinusitis.
Levy JM, Mace JC, Sansoni ER, Soler ZM, Smith TL. Levy JM, et al. Int Forum Allergy Rhinol. 2016 Nov;6(11):1188-1195. doi: 10.1002/alr.21800. Epub 2016 May 24. Int Forum Allergy Rhinol. 2016. PMID: 27218483 Free PMC article.
METHODS: Adult participants with medically recalcitrant CRS were prospectively enrolled into a multi-institutional cohort study and observed for 18 months after ESS. Olfaction was operationalized using BSIT scores collected at baseline, 6 months, 12 months, and 18 m …
METHODS: Adult participants with medically recalcitrant CRS were prospectively enrolled into a multi-institutional cohort study and obser
Churg-Strauss syndrome: a new endotype of severe asthma? Results of 14 Turkish patients.
Yılmaz İ, Çelik G, Aydın Ö, Özdemir SK, Soyyiğit Ş, Sözener Z, Özgüçlü S, Atasoy Ç, Düzgün N, Mungan D, Sin B, Demirel YS, Mısırlıgil Z. Yılmaz İ, et al. Clin Respir J. 2015 Jul;9(3):350-8. doi: 10.1111/crj.12154. Epub 2014 May 19. Clin Respir J. 2015. PMID: 24761830
Initial symptoms were worsening asthma (n = 14; 100%) and skin lesions (n = 6; 43%). All patients had a diagnosis of asthma and nasal polyps, whereas 57.1% had aspirin hypersensitivity at the time of diagnosis. ...None of the cases were able to stop th …
Initial symptoms were worsening asthma (n = 14; 100%) and skin lesions (n = 6; 43%). All patients had a diagnosis of asthma and
14 results