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Bexarotene.
[No authors listed] [No authors listed] 2017 Sep 26. LiverTox: Clinical and Research Information on Drug-Induced Liver Injury [Internet]. Bethesda (MD): National Institute of Diabetes and Digestive and Kidney Diseases; 2012–. 2017 Sep 26. LiverTox: Clinical and Research Information on Drug-Induced Liver Injury [Internet]. Bethesda (MD): National Institute of Diabetes and Digestive and Kidney Diseases; 2012–. PMID: 31643658 Free Books & Documents. Review.
Bexarotene is a retinoid analogue that is used to treat the skin manifestations of cutaneous T cell lymphoma (CTCL). Bexarotene therapy is associated with a high rate of serum enzyme elevations and rare instances of clinically apparent acute liver injury....
Bexarotene is a retinoid analogue that is used to treat the skin manifestations of cutaneous T cell lymphoma (CTCL). Bexarotene …
Bexarotene.
Lowe MN, Plosker GL. Lowe MN, et al. Am J Clin Dermatol. 2000 Jul-Aug;1(4):245-50; discussion 251-2. doi: 10.2165/00128071-200001040-00006. Am J Clin Dermatol. 2000. PMID: 11702369 Review.
An overall response rate of 63% was reported after topical bexarotene 0.1 to 1% twice daily in patients with early stage CTCL. ...At clinically relevant oral dosages, bexarotene significantly decreases levels of serum thyrotropin and free thyroxine. ...
An overall response rate of 63% was reported after topical bexarotene 0.1 to 1% twice daily in patients with early stage CTCL. ...At …
The novel function of bexarotene for neurological diseases.
Liu Y, Wang P, Jin G, Shi P, Zhao Y, Guo J, Yin Y, Shao Q, Li P, Yang P. Liu Y, et al. Ageing Res Rev. 2023 Sep;90:102021. doi: 10.1016/j.arr.2023.102021. Epub 2023 Jul 24. Ageing Res Rev. 2023. PMID: 37495118 Review.
Bexarotene, a retinoid X receptor (RXR) agonist, is approved by FDA to treat cutaneous T-cell lymphoma. ...Here, we briefly discuss the characteristics, applications, and adverse effects of bexarotene, summarize its pharmacological mechanisms and therapeutic results …
Bexarotene, a retinoid X receptor (RXR) agonist, is approved by FDA to treat cutaneous T-cell lymphoma. ...Here, we briefly discuss t …
Bexarotene-induced cell death in ovarian cancer cells through Caspase-4-gasdermin E mediated pyroptosis.
Kobayashi T, Mitsuhashi A, Hongying P, Shioya M, Kojima K, Nishikimi K, Yahiro K, Shozu M. Kobayashi T, et al. Sci Rep. 2022 Jul 1;12(1):11123. doi: 10.1038/s41598-022-15348-7. Sci Rep. 2022. PMID: 35778597 Free PMC article.
Bexarotene reduced cell proliferation in all concentrations in both the cells. ...Thus, bexarotene may serve as a novel therapeutic agent for ovarian cancer....
Bexarotene reduced cell proliferation in all concentrations in both the cells. ...Thus, bexarotene may serve as a novel therap …
Bexarotene: a clinical review.
Farol LT, Hymes KB. Farol LT, et al. Expert Rev Anticancer Ther. 2004 Apr;4(2):180-8. doi: 10.1586/14737140.4.2.180. Expert Rev Anticancer Ther. 2004. PMID: 15056048 Review.
Bexarotene (Targretin, Ligand Pharmaceuticals Inc.) is a synthetic retinoid analog with specific affinity for the retinoid X receptor and belongs to a group of compounds called rexinoids. ...Subsequent Phase II/III trials have demonstrated a greater than 50% response rate …
Bexarotene (Targretin, Ligand Pharmaceuticals Inc.) is a synthetic retinoid analog with specific affinity for the retinoid X receptor …
Bexarotene improves motor function after spinal cord injury in mice.
Wang X, Shen Z, Zhang H, Zhang HJ, Li F, Yu L, Chen H, Zhou K, Xu H, Sheng S. Wang X, et al. Neural Regen Res. 2023 Dec;18(12):2733-2742. doi: 10.4103/1673-5374.373676. Neural Regen Res. 2023. PMID: 37449638 Free PMC article.
Bexarotene has been proven to promote autophagy, but it has not been used in the treatment of spinal cord injury. To investigate the effects of bexarotene on spinal cord injury, we established a mouse model of T11-T12 spinal cord contusion and performed daily intrap …
Bexarotene has been proven to promote autophagy, but it has not been used in the treatment of spinal cord injury. To investigate the …
Photodegradation of Bexarotene and Its Implication for Cytotoxicity.
Kryczyk-Poprawa A, Zupkó I, Bérdi P, Żmudzki P, Piotrowska J, Pękala E, Berdys A, Muszyńska B, Opoka W. Kryczyk-Poprawa A, et al. Pharmaceutics. 2021 Aug 7;13(8):1220. doi: 10.3390/pharmaceutics13081220. Pharmaceutics. 2021. PMID: 34452181 Free PMC article.
The bexarotene photostability testing was performed in ethanol solutions and in formulations applied on PMMA plates. ...The presence of photocatalysts such as TiO(2) or ZnO, as well as the organic UV filters avobenzone, benzophenone-3, meradimate, and homosalate, could con …
The bexarotene photostability testing was performed in ethanol solutions and in formulations applied on PMMA plates. ...The presence …
Emerging roles of bexarotene in the prevention, treatment and anti-drug resistance of cancers.
Shen D, Yu X, Wu Y, Chen Y, Li G, Cheng F, Xia L. Shen D, et al. Expert Rev Anticancer Ther. 2018 May;18(5):487-499. doi: 10.1080/14737140.2018.1449648. Epub 2018 Mar 20. Expert Rev Anticancer Ther. 2018. PMID: 29521139 Review.
However, only a subpopulation of bexarotene treated patients benefited from bexarotene administration in most cases. ...Further identification and verification of bexarotene response biomarkers may finally lead to the personalized clinical application of b …
However, only a subpopulation of bexarotene treated patients benefited from bexarotene administration in most cases. ...Furthe …
Bexarotene: a promising anticancer agent.
Qu L, Tang X. Qu L, et al. Cancer Chemother Pharmacol. 2010 Jan;65(2):201-5. doi: 10.1007/s00280-009-1140-4. Epub 2009 Sep 24. Cancer Chemother Pharmacol. 2010. PMID: 19777233 Review.
The biologic effects of retinoids are mediated by two distinct families of intracellular receptors: retinoid acid receptors (RARs)-alpha, -beta and -gamma and retinoid X receptors (RXR)-alpha, -beta and -gamma. Bexarotene is a selective RXR agonist, which exerts its effect …
The biologic effects of retinoids are mediated by two distinct families of intracellular receptors: retinoid acid receptors (RARs)-alpha, -b …
Bexarotene-induced hypothyroidism: Characteristics and therapeutic strategies.
Makita N, Manaka K, Sato J, Mitani K, Nangaku M, Iiri T. Makita N, et al. Clin Endocrinol (Oxf). 2019 Jul;91(1):195-200. doi: 10.1111/cen.13975. Epub 2019 Apr 11. Clin Endocrinol (Oxf). 2019. PMID: 30903705
This study aimed to characterize the kinetics and dose dependency of bexarotene-induced CH in Japanese patients. DESIGN AND PATIENTS: Sixty-six Japanese patients with CTCL were retrospectively investigated by evaluating thyroid function during the early phase of bexarot …
This study aimed to characterize the kinetics and dose dependency of bexarotene-induced CH in Japanese patients. DESIGN AND PATIENTS: …
941 results