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Neonatal Survival After Serial Amnioinfusions for Bilateral Renal Agenesis: The Renal Anhydramnios Fetal Therapy Trial.
Miller JL, Baschat AA, Rosner M, Blumenfeld YJ, Moldenhauer JS, Johnson A, Schenone MH, Zaretsky MV, Chmait RH, Gonzalez JM, Miller RS, Moon-Grady AJ, Bendel-Stenzel E, Keiser AM, Avadhani R, Jelin AC, Davis JM, Warren DS, Hanley DF, Watkins JA, Samuels J, Sugarman J, Atkinson MA. Miller JL, et al. JAMA. 2023 Dec 5;330(21):2096-2105. doi: 10.1001/jama.2023.21153. JAMA. 2023. PMID: 38051327 Free PMC article. Clinical Trial.
IMPORTANCE: Early anhydramnios during pregnancy, resulting from fetal bilateral renal agenesis, causes lethal pulmonary hypoplasia in neonates. ...Outcomes are reported for 21 maternal-fetal pairs with confirmed anhydramnios due to isolated fetal bilateral …
IMPORTANCE: Early anhydramnios during pregnancy, resulting from fetal bilateral renal agenesis, causes lethal pulmonary …
Design and Protocol of the Renal Anhydramnios Fetal Therapy (RAFT) Trial.
Atkinson MA, Jelin EB, Baschat A, Blumenfeld YJ, Chmait RH, O'Hare E, Moldenhauer JS, Zaretsky MV, Miller RS, Ruano R, Gonzalez JM, Johnson A, Mould WA, Davis JM, Hanley DF, Keiser AM, Rosner M, Miller JL. Atkinson MA, et al. Clin Ther. 2022 Aug;44(8):1161-1171. doi: 10.1016/j.clinthera.2022.07.001. Epub 2022 Jul 30. Clin Ther. 2022. PMID: 35918190 Free PMC article. Clinical Trial.
PURPOSE: Anhydramnios secondary to anuria before 22 weeks of gestational age and congenital bilateral renal agenesis before 26 weeks of gestational age are collectively referred to as early-pregnancy renal anhydramnios. Early-pregnancy renal anhydramnios occu …
PURPOSE: Anhydramnios secondary to anuria before 22 weeks of gestational age and congenital bilateral renal agenesis be …
Etiology and management of early pregnancy renal anhydramnios: Is there a place for serial amnioinfusions?
Jelin AC, Sagaser KG, Forster KR, Ibekwe T, Norton ME, Jelin EB. Jelin AC, et al. Prenat Diagn. 2020 Apr;40(5):528-537. doi: 10.1002/pd.5658. Epub 2020 Feb 19. Prenat Diagn. 2020. PMID: 32003482 Free PMC article. Review.
There are several etiologies of fetal renal failure that result in EPRA including bilateral renal agenesis, cystic kidney disease, and lower urinary tract obstruction. ...Preliminary data from case reports demonstrate an association between serial amnioinfusi …
There are several etiologies of fetal renal failure that result in EPRA including bilateral renal agenesis, cystic kidn …
Angiotensin-II Use for Refractory Hypotension in an Infant With Bilateral Renal Agenesis.
Razdan S, Davis AS, Tidmarsh G, Hintz SR, Grimm PC, Chock VY. Razdan S, et al. Pediatrics. 2024 Jan 1;153(1):e2023062128. doi: 10.1542/peds.2023-062128. Pediatrics. 2024. PMID: 38098437
Infants with bilateral renal agenesis may episodically develop severe hypotension that can be refractory to traditional vasopressors. ...This case demonstrates that angiotensin-II may be a helpful agent to treat refractory hypotension in infants with bilat …
Infants with bilateral renal agenesis may episodically develop severe hypotension that can be refractory to traditional …
Monoamniotic twin discordant for bilateral renal agenesis with normal pulmonary function.
Perez-Brayfield MR, Kirsch AJ, Smith EA. Perez-Brayfield MR, et al. Urology. 2004 Sep;64(3):589. doi: 10.1016/j.urology.2003.10.053. Urology. 2004. PMID: 15351606 Review.
We describe the unusual case of a monoamniotic twin discordant for bilateral renal agenesis with normal pulmonary function. This case shows the importance of normal renal function in the production of amniotic fluid and its relationship to the proper developm …
We describe the unusual case of a monoamniotic twin discordant for bilateral renal agenesis with normal pulmonary funct …
Assessment of fluid status in neonatal dialysis: the need for new tools.
Nourbakhsh N, Benador N. Nourbakhsh N, et al. Pediatr Nephrol. 2023 Apr;38(4):1373-1379. doi: 10.1007/s00467-022-05829-2. Epub 2022 Dec 2. Pediatr Nephrol. 2023. PMID: 36459242 Free PMC article.
BACKGROUND: Assessment of fluid status in neonatal dialysis has largely focused on traditional tools including clinical assessment, serial weights, and blood pressure (BP) measurements. However, in infants on kidney replacement therapy, the assessment of fluid overload is …
BACKGROUND: Assessment of fluid status in neonatal dialysis has largely focused on traditional tools including clinical assessment, s …
Maternal body mass index and lifestyle exposures and the risk of bilateral renal agenesis or hypoplasia: the National Birth Defects Prevention Study.
Slickers JE, Olshan AF, Siega-Riz AM, Honein MA, Aylsworth AS; National Birth Defects Prevention Study. Slickers JE, et al. Am J Epidemiol. 2008 Dec 1;168(11):1259-67. doi: 10.1093/aje/kwn248. Epub 2008 Oct 3. Am J Epidemiol. 2008. PMID: 18835865
Increased maternal body mass index, maternal smoking, and alcohol exposure during pregnancy have been inconsistently reported as potential risk factors for renal birth defects. The low incidence of the most severe renal anomaly, bilateral renal agenesis or hy …
Increased maternal body mass index, maternal smoking, and alcohol exposure during pregnancy have been inconsistently reported as potential r …
Outcomes and management strategies in pregnancies with early onset oligohydramnios.
Ulkumen BA, Pala HG, Baytur YB, Koyuncu FM. Ulkumen BA, et al. Clin Exp Obstet Gynecol. 2015;42(3):355-7. Clin Exp Obstet Gynecol. 2015. PMID: 26152010
Thirty-seven pregnancies were anhydramniotic, 13 fetuses had associated anomalies, five of them had multicyctic dysplastic kidney, five had bilateral renal agenesis, one had hypoplastic right heart syndrome, one had clubfoot, and one had ventricular septal de …
Thirty-seven pregnancies were anhydramniotic, 13 fetuses had associated anomalies, five of them had multicyctic dysplastic kidney, five had …
The use of saline solution as a contrast medium in suspected diaphragmatic hernia and renal agenesis.
Haeusler MC, Ryan G, Robson SC, Lipitz S, Rodeck CH. Haeusler MC, et al. Am J Obstet Gynecol. 1993 May;168(5):1486-92. doi: 10.1016/s0002-9378(11)90786-8. Am J Obstet Gynecol. 1993. PMID: 8498432
In the cases with suspected renal agenesis, amnioinfusion led to recognition of a previously unsuspected sirenomelia, and intraperitoneal instillation demonstrated empty renal fossae in four cases. The final fetus with bilateral renal agenesis was thought ant …
In the cases with suspected renal agenesis, amnioinfusion led to recognition of a previously unsuspected sirenomelia, and intraperitoneal in …
Associations between maternal periconceptional exposure to secondhand tobacco smoke and major birth defects.
Hoyt AT, Canfield MA, Romitti PA, Botto LD, Anderka MT, Krikov SV, Tarpey MK, Feldkamp ML. Hoyt AT, et al. Am J Obstet Gynecol. 2016 Nov;215(5):613.e1-613.e11. doi: 10.1016/j.ajog.2016.07.022. Epub 2016 Jul 18. Am J Obstet Gynecol. 2016. PMID: 27443814
The adjusted odds ratios for any vs no secondhand smoke exposure in the household or workplace/school and isolated birth defects were significantly elevated for neural tube defects (anencephaly: adjusted odds ratio, 1.66; 95% confidence interval, 1.22-2.25; and spina bifida: adju …
The adjusted odds ratios for any vs no secondhand smoke exposure in the household or workplace/school and isolated birth defects were signif …