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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1965 1
1969 1
1970 1
1975 3
1976 7
1977 3
1978 6
1979 9
1980 1
1981 9
1982 6
1983 14
1984 11
1985 15
1986 16
1987 26
1988 19
1989 32
1990 25
1991 29
1992 23
1993 42
1994 32
1995 30
1996 37
1997 29
1998 25
1999 27
2000 23
2001 34
2002 58
2003 61
2004 44
2005 30
2006 46
2007 43
2008 46
2009 52
2010 42
2011 41
2012 37
2013 31
2014 33
2015 38
2016 44
2017 43
2018 45
2019 24
2020 39
2021 34
2022 31
2023 22
2024 8

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1,327 results

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Quoted phrase not found in phrase index: "Blast phase chronic myelogenous leukemia, BCR-ABL1 positive"
Page 1
Ponatinib and blinatumomab for Philadelphia chromosome-positive acute lymphoblastic leukaemia: a US, single-centre, single-arm, phase 2 trial.
Jabbour E, Short NJ, Jain N, Huang X, Montalban-Bravo G, Banerjee P, Rezvani K, Jiang X, Kim KH, Kanagal-Shamanna R, Khoury JD, Patel K, Kadia TM, Daver N, Chien K, Alvarado Y, Garcia-Manero G, Issa GC, Haddad FG, Kwari M, Thankachan J, Delumpa R, Macaron W, Garris R, Konopleva M, Ravandi F, Kantarjian H. Jabbour E, et al. Lancet Haematol. 2023 Jan;10(1):e24-e34. doi: 10.1016/S2352-3026(22)00319-2. Epub 2022 Nov 16. Lancet Haematol. 2023. PMID: 36402146 Clinical Trial.
The primary endpoints were complete molecular response (defined as absence of a detectable BCR-ABL1 transcript by PCR at a sensitivity of 0.01%) in patients with newly diagnosed disease and overall response in patients with relapsed or refractory disease or chron …
The primary endpoints were complete molecular response (defined as absence of a detectable BCR-ABL1 transcript by PCR at a sen …
Pathogenesis and management of accelerated and blast phases of chronic myeloid leukemia.
Senapati J, Jabbour E, Kantarjian H, Short NJ. Senapati J, et al. Leukemia. 2023 Jan;37(1):5-17. doi: 10.1038/s41375-022-01736-5. Epub 2022 Oct 29. Leukemia. 2023. PMID: 36309558 Review.
The treatment of chronic myeloid leukemia (CML) with tyrosine kinase inhibitors (TKIs) has been a model for cancer therapy development. Though most patients with CML have a normal quality and duration of life with TKI therapy, some patients progress to accelerated …
The treatment of chronic myeloid leukemia (CML) with tyrosine kinase inhibitors (TKIs) has been a model for cancer therapy dev …
Treatment of blast phase chronic myeloid leukaemia: A rare and challenging entity.
Copland M. Copland M. Br J Haematol. 2022 Dec;199(5):665-678. doi: 10.1111/bjh.18370. Epub 2022 Jul 22. Br J Haematol. 2022. PMID: 35866251 Free PMC article. Review.
Despite the success of BCR-ABL-specific tyrosine kinase inhibitors (TKIs) such as imatinib in chronic phase (CP) chronic myeloid leukaemia (CML), patients with blast phase (BP)-CML continue to have a dismal outcome with median survival of …
Despite the success of BCR-ABL-specific tyrosine kinase inhibitors (TKIs) such as imatinib in chronic phase (CP) chr …
Genetic landscape of chronic myeloid leukemia.
Ochi Y. Ochi Y. Int J Hematol. 2023 Jan;117(1):30-36. doi: 10.1007/s12185-022-03510-w. Epub 2022 Dec 7. Int J Hematol. 2023. PMID: 36477676 Review.
Chronic myeloid leukemia (CML) is a myeloproliferative neoplasm caused by the BCR::ABL1 fusion gene, which aberrantly activates ABL1 kinase and promotes the overproduction of leukemic cells. CML typically develops in the chronic phase …
Chronic myeloid leukemia (CML) is a myeloproliferative neoplasm caused by the BCR::ABL1 fusion gene, which aberr …
B-Lymphoid Blast Phase-Chronic Myeloid Leukemia: Current Therapeutics.
Yohannan B, George B. Yohannan B, et al. Int J Mol Sci. 2022 Oct 5;23(19):11836. doi: 10.3390/ijms231911836. Int J Mol Sci. 2022. PMID: 36233138 Free PMC article. Review.
Blast crisis (BC) is one of the most dreaded complications of chronic myeloid leukemia (CML). Fortunately, the incidence of BC has diminished markedly in the BCR-ABL tyrosine kinase inhibitor (TKI) era. The primary objective of initial treatment …
Blast crisis (BC) is one of the most dreaded complications of chronic myeloid leukemia (CML). Fortunately, the i …
Management and Outcomes of Blast Transformed Chronic Myelomonocytic Leukemia.
Hammond D, Montalban-Bravo G. Hammond D, et al. Curr Hematol Malig Rep. 2021 Oct;16(5):405-417. doi: 10.1007/s11899-021-00643-3. Epub 2021 Sep 9. Curr Hematol Malig Rep. 2021. PMID: 34499330 Review.
PURPOSE OF REVIEW: Despite recent advances in the treatment of de novo acute myeloid leukemia (AML), AML arising from antecedent chronic myelomonocytic leukemia (CMML) continues to have dismal outcomes. ...Here, we review these biologic drivers, outcomes with …
PURPOSE OF REVIEW: Despite recent advances in the treatment of de novo acute myeloid leukemia (AML), AML arising from antecedent c …
An Update on the Management of Advanced Phase Chronic Myeloid Leukemia.
Short NJ, Senapati J, Jabbour E. Short NJ, et al. Curr Hematol Malig Rep. 2023 Dec;18(6):234-242. doi: 10.1007/s11899-023-00709-4. Epub 2023 Aug 31. Curr Hematol Malig Rep. 2023. PMID: 37651057 Review.
PURPOSE OF REVIEW: While most patients with chronic myeloid leukemia (CML) present in a chronic phase and are expected to have a normal life expectancy, some patients present with or progress to a more aggressive accelerated phase (AP) or bla …
PURPOSE OF REVIEW: While most patients with chronic myeloid leukemia (CML) present in a chronic phase and are ex …
International phase 3 study of azacitidine vs conventional care regimens in older patients with newly diagnosed AML with >30% blasts.
Dombret H, Seymour JF, Butrym A, Wierzbowska A, Selleslag D, Jang JH, Kumar R, Cavenagh J, Schuh AC, Candoni A, Récher C, Sandhu I, Bernal del Castillo T, Al-Ali HK, Martinelli G, Falantes J, Noppeney R, Stone RM, Minden MD, McIntyre H, Songer S, Lucy LM, Beach CL, Döhner H. Dombret H, et al. Blood. 2015 Jul 16;126(3):291-9. doi: 10.1182/blood-2015-01-621664. Epub 2015 May 18. Blood. 2015. PMID: 25987659 Free PMC article. Clinical Trial.
This multicenter, randomized, open-label, phase 3 trial evaluated azacitidine efficacy and safety vs conventional care regimens (CCRs) in 488 patients age 65 years with newly diagnosed acute myeloid leukemia (AML) with >30% bone marrow blasts. Befor …
This multicenter, randomized, open-label, phase 3 trial evaluated azacitidine efficacy and safety vs conventional care …
New routes to eradicating chronic myelogenous leukemia stem cells by targeting metabolism.
Naka K. Naka K. Int J Hematol. 2021 May;113(5):648-655. doi: 10.1007/s12185-021-03112-y. Epub 2021 Mar 5. Int J Hematol. 2021. PMID: 33666817 Review.
Chronic myelogenous leukemia (CML) stem cells are the cellular source of the vast majority of mature CML cells and responsible for relapse of CML disease post-tyrosine kinase inhibitor (TKI) therapy. ...With respect to glucose metabolism, CML stem cells eleva …
Chronic myelogenous leukemia (CML) stem cells are the cellular source of the vast majority of mature CML cells and resp …
Advanced-phase chronic myeloid leukemia.
Cortes J, Kantarjian H. Cortes J, et al. Semin Hematol. 2003 Jan;40(1):79-86. doi: 10.1053/shem.2003.50005. Semin Hematol. 2003. PMID: 12563614 Review.
Chronic myeloid leukemia (CML) typically runs a biphasic or triphasic course, with diagnoses usually made in the chronic phase (CP). Without effective treatment, patients eventually progress to a blastic phase (BP), frequently through an interme …
Chronic myeloid leukemia (CML) typically runs a biphasic or triphasic course, with diagnoses usually made in the chronic …
1,327 results