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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1981 1
1983 2
1984 1
1986 4
1987 1
1988 1
1989 3
1990 1
1991 1
1992 2
1993 2
1994 1
1995 2
1998 1
2001 2
2003 1
2004 1
2006 3
2008 2
2009 1
2010 1
2011 2
2012 3
2013 5
2014 1
2015 1
2016 4
2017 5
2018 5
2019 1
2020 4
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2022 1
2023 2
2024 1

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67 results

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Page 1
BLM overexpression as a predictive biomarker for CHK1 inhibitor response in PARP inhibitor-resistant BRCA-mutant ovarian cancer.
Gupta N, Huang TT, Nair JR, An D, Zurcher G, Lampert EJ, McCoy A, Cimino-Mathews A, Swisher EM, Radke MR, Lockwood CM, Reichel JB, Chiang CY, Wilson KM, Cheng KC, Nousome D, Lee JM. Gupta N, et al. Sci Transl Med. 2023 Jun 21;15(701):eadd7872. doi: 10.1126/scitranslmed.add7872. Epub 2023 Jun 21. Sci Transl Med. 2023. PMID: 37343085 Free PMC article. Clinical Trial.
Exploratory biomarker analyses revealed that replication stress and fork stabilization were associated with clinical benefit to CHK1i. In particular, overexpression of Bloom syndrome RecQ helicase (BLM) and cyclin E1 (CCNE1) overexpression or copy number gain …
Exploratory biomarker analyses revealed that replication stress and fork stabilization were associated with clinical benefit to CHK1i …
Progeroid syndromes and UV-induced oxidative DNA damage.
Kamenisch Y, Berneburg M. Kamenisch Y, et al. J Investig Dermatol Symp Proc. 2009 Aug;14(1):8-14. doi: 10.1038/jidsymp.2009.6. J Investig Dermatol Symp Proc. 2009. PMID: 19675546 Free article. Review.
Progeroid syndromes are a group of diseases characterized by signs of premature aging. These syndromes comprise diseases such as Werner syndrome, Bloom syndrome, Rothmund-Thomson syndrome, Hutchinson-Gilford syndrome, Fanconi anemia, and ataxia-telangiectasia, as we …
Progeroid syndromes are a group of diseases characterized by signs of premature aging. These syndromes comprise diseases such as Werner synd …
Understanding photodermatoses associated with defective DNA repair: Syndromes with cancer predisposition.
Giordano CN, Yew YW, Spivak G, Lim HW. Giordano CN, et al. J Am Acad Dermatol. 2016 Nov;75(5):855-870. doi: 10.1016/j.jaad.2016.03.045. J Am Acad Dermatol. 2016. PMID: 27745641 Review.
This review will focus specifically on the syndromes with malignant potential, including xeroderma pigmentosum, Bloom syndrome, and Rothmund-Thomson syndrome. The typical phenotypic findings of each disorder will be examined and contrasted, including noncutaneous id …
This review will focus specifically on the syndromes with malignant potential, including xeroderma pigmentosum, Bloom syndrome …
Bloom syndrome does not always present with sun-sensitive facial erythema.
Bouman A, van Koningsbruggen S, Karakullukcu MB, Schreuder WH, Lakeman P. Bouman A, et al. Eur J Med Genet. 2018 Feb;61(2):94-97. doi: 10.1016/j.ejmg.2017.10.010. Epub 2017 Oct 19. Eur J Med Genet. 2018. PMID: 29056561
It has been previously reported that in some individuals with Bloom syndrome these sun-sensitive lesions are less prominent or even absent. ...We would like to underline that phenotypic variation regarding this "hallmark" feature of Bloom syndrome exis …
It has been previously reported that in some individuals with Bloom syndrome these sun-sensitive lesions are less prominent or …
PARP1 negatively regulates transcription of BLM through its interaction with HSP90AB1 in prostate cancer.
Huang M, Chen L, Guo Y, Ruan Y, Xu H. Huang M, et al. J Transl Med. 2023 Jul 6;21(1):445. doi: 10.1186/s12967-023-04288-z. J Transl Med. 2023. PMID: 37415147 Free PMC article.
Increased BLM expression showed significant correlations with advanced clinical stage (P = 0.022) and Gleason grade (P = 0.006). In vitro experiments demonstrated that BLM knockdown exerted inhibitory effects on cell proliferation, clone formation, invasion, and migration. …
Increased BLM expression showed significant correlations with advanced clinical stage (P = 0.022) and Gleason grade (P = 0.006). In v …
Bloom syndrome radials are predominantly non-homologous and are suppressed by phosphorylated BLM.
Owen N, Hejna J, Rennie S, Mitchell A, Newell AH, Ziaie N, Moses RE, Olson SB. Owen N, et al. Cytogenet Genome Res. 2014;144(4):255-263. doi: 10.1159/000375247. Epub 2015 Feb 28. Cytogenet Genome Res. 2014. PMID: 25766002 Free PMC article.
Biallelic mutations in BLM cause Bloom syndrome (BS), a genome instability disorder characterized by growth retardation, sun sensitivity and a predisposition to cancer. ...However, we find that radials in BS cells occur over 95% between non-homologous chromosomes, a …
Biallelic mutations in BLM cause Bloom syndrome (BS), a genome instability disorder characterized by growth retardation, sun s …
Human RecQL4 helicase plays multifaceted roles in the genomic stability of normal and cancer cells.
Mo D, Zhao Y, Balajee AS. Mo D, et al. Cancer Lett. 2018 Jan 28;413:1-10. doi: 10.1016/j.canlet.2017.10.021. Epub 2017 Nov 7. Cancer Lett. 2018. PMID: 29080750 Review.
Mutational inactivation of Werner (WRN) and Bloom (BLM) genes results in Werner syndrome (WS) and Bloom syndrome (BS) respectively. However, mutations in RecQL4 result in three human disorders: (I) Rothmund-Thomson syndrome (RTS), (II) RAPADILINO and (III) Baller-Ge …
Mutational inactivation of Werner (WRN) and Bloom (BLM) genes results in Werner syndrome (WS) and Bloom syndrome (BS) respecti …
Infantile fibrosarcoma with TPM3-NTRK1 fusion in a boy with Bloom syndrome.
Huson SM, Staab T, Pereira M, Ward H, Paredes R, Evans DG, Baumhoer D, O'Sullivan J, Cheesman E, Schindler D, Meyer S. Huson SM, et al. Fam Cancer. 2022 Jan;21(1):85-90. doi: 10.1007/s10689-020-00221-1. Epub 2020 Nov 21. Fam Cancer. 2022. PMID: 33219493 Free PMC article.
Bloom syndrome (BS) is a genomic and chromosomal instability disorder with prodigious cancer predisposition caused by pathogenic variants in BLM. We report the clinical and genetic details of a boy who first presented with infantile fibrosarcoma (IFS) at the …
Bloom syndrome (BS) is a genomic and chromosomal instability disorder with prodigious cancer predisposition caused by pathogen …
67 results