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Page 1
Full-exon pyrosequencing screening of BRCA germline mutations in Mexican women with inherited breast and ovarian cancer.
Vaca-Paniagua F, Alvarez-Gomez RM, Fragoso-Ontiveros V, Vidal-Millan S, Herrera LA, Cantú D, Bargallo-Rocha E, Mohar A, López-Camarillo C, Pérez-Plasencia C. Vaca-Paniagua F, et al. PLoS One. 2012;7(5):e37432. doi: 10.1371/journal.pone.0037432. Epub 2012 May 24. PLoS One. 2012. PMID: 22655046 Free PMC article.
The most prevalent genes causing this pathology are BRCA1 and BRCA2 (breast cancer early onset 1 and 2), which also predispose to other cancers. ...Moreover, we discovered 16 variants with unknown clinical significance (11 in exons and 5 in introns); 4 …
The most prevalent genes causing this pathology are BRCA1 and BRCA2 (breast cancer early onset 1 and 2), which a …
DNA damage among thyroid cancer and multiple cancer cases, controls, and long-lived individuals.
Sigurdson AJ, Hauptmann M, Alexander BH, Doody MM, Thomas CB, Struewing JP, Jones IM. Sigurdson AJ, et al. Mutat Res. 2005 Oct 3;586(2):173-88. doi: 10.1016/j.mrgentox.2005.07.001. Mutat Res. 2005. PMID: 16099702
To assess capacity to modulate endogenous DNA damage among radiologic technologists who had been diagnosed with breast cancer and another malignancy (breast-other, n=42), early-onset breast cancer (early-onset, age <or=35; n=38), thyroid cancer (n=6 …
To assess capacity to modulate endogenous DNA damage among radiologic technologists who had been diagnosed with breast cancer and another ma …
Higher incidence of isolated brain metastases in ovarian cancer patients with previous early breast cancer.
Faluyi OO, Gourley C, Smyth JF, Faratian D, Williams AR, Rye T, Rye R, Stewart M, Mackean MJ. Faluyi OO, et al. Int J Gynecol Cancer. 2010 Dec;20(9):1511-7. Int J Gynecol Cancer. 2010. PMID: 21370594
BACKGROUND: The pathogenesis of brain metastasis as a relatively rare complication of epithelial ovarian cancer is poorly understood. Some observations suggest that brain metastases from ovarian cancer are becoming more common and that ovarian cancers, which metastasize to …
BACKGROUND: The pathogenesis of brain metastasis as a relatively rare complication of epithelial ovarian cancer is poorly understood. Some …
Poly (ADP) ribose polymerase inhibition: A potential treatment of malignant peripheral nerve sheath tumor.
Kivlin CM, Watson KL, Al Sannaa GA, Belousov R, Ingram DR, Huang KL, May CD, Bolshakov S, Landers SM, Kalam AA, Slopis JM, McCutcheon IE, Pollock RE, Lev D, Lazar AJ, Torres KE. Kivlin CM, et al. Cancer Biol Ther. 2016;17(2):129-38. doi: 10.1080/15384047.2015.1108486. Epub 2015 Dec 9. Cancer Biol Ther. 2016. PMID: 26650448 Free PMC article.
Poly (ADP) ribose polymerase (PARP) inhibitors, first evaluated nearly a decade ago, are primarily used in malignancies with known defects in DNA repair genes, such as alterations in breast cancer, early onset 1/2 (BRCA1/2). While no specific mutations …
Poly (ADP) ribose polymerase (PARP) inhibitors, first evaluated nearly a decade ago, are primarily used in malignancies with known defects i …
Association of BRCA1 with the inactive X chromosome and XIST RNA.
Ganesan S, Silver DP, Drapkin R, Greenberg R, Feunteun J, Livingston DM. Ganesan S, et al. Philos Trans R Soc Lond B Biol Sci. 2004 Jan 29;359(1441):123-8. doi: 10.1098/rstb.2003.1371. Philos Trans R Soc Lond B Biol Sci. 2004. PMID: 15065664 Free PMC article.
Breast cancer, early onset 1 (BRCA1) encodes a nuclear protein that participates in breast and ovarian cancer suppression. The molecular basis for the gender and tissue specificity of the BRCA1 cancer syndrome is unknown. Recently, we observed t …
Breast cancer, early onset 1 (BRCA1) encodes a nuclear protein that participates in breast and ovarian cancer su …
Association of EGFR mutation or ALK rearrangement with expression of DNA repair and synthesis genes in never-smoker women with pulmonary adenocarcinoma.
Ren S, Chen X, Kuang P, Zheng L, Su C, Li J, Li B, Wang Y, Liu L, Hu Q, Zhang J, Tang L, Li X, Zhou C, Schmid-Bindert G. Ren S, et al. Cancer. 2012 Nov 15;118(22):5588-94. doi: 10.1002/cncr.27603. Epub 2012 May 8. Cancer. 2012. PMID: 22569898 Free article.
BACKGROUND: Epidermal growth factor receptor (EGFR) mutation and anaplastic lymphoma kinase (ALK) rearrangement may predict the outcome of targeted drug therapy and also are associated with the efficacy of chemotherapy in patients with nonsmall cell lung cancer (NSCLC). Th …
BACKGROUND: Epidermal growth factor receptor (EGFR) mutation and anaplastic lymphoma kinase (ALK) rearrangement may predict the outco …