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164 results

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Quoted phrase not found in phrase index: "Breast-ovarian cancer, familial, susceptibility to, 4"
Page 1
Frequency of Germline Mutations in 25 Cancer Susceptibility Genes in a Sequential Series of Patients With Breast Cancer.
Tung N, Lin NU, Kidd J, Allen BA, Singh N, Wenstrup RJ, Hartman AR, Winer EP, Garber JE. Tung N, et al. J Clin Oncol. 2016 May 1;34(13):1460-8. doi: 10.1200/JCO.2015.65.0747. Epub 2016 Mar 14. J Clin Oncol. 2016. PMID: 26976419 Free PMC article.

Whereas young age (P < .01), Ashkenazi Jewish ancestry (P < .01), triple-negative breast cancer (P = .01), and family history of breast/ovarian cancer (P = .01) predicted for BRCA1/2 mutations, no factors predicted for mutations in other b

…

Whereas young age (P < .01), Ashkenazi Jewish ancestry (P < .01), triple-negative breast cancer (P = .01), and family hi

…
Comparison of BRCA versus non-BRCA germline mutations and associated somatic mutation profiles in patients with unselected breast cancer.
Chen B, Zhang G, Li X, Ren C, Wang Y, Li K, Mok H, Cao L, Wen L, Jia M, Li C, Guo L, Wei G, Lin J, Li Y, Zhang Y, Han-Zhang H, Liu J, Lizaso A, Liao N. Chen B, et al. Aging (Albany NY). 2020 Feb 24;12(4):3140-3155. doi: 10.18632/aging.102783. Epub 2020 Feb 24. Aging (Albany NY). 2020. PMID: 32091409 Free PMC article.
We interrogated the germline and somatic mutational profile of 524 Chinese breast cancer patients with various stages unselected for predisposing factors using a panel consisting of 520 cancer-related genes including 62 cancer susceptibility genes. ... …
We interrogated the germline and somatic mutational profile of 524 Chinese breast cancer patients with various stages unselected for …
Multigene panel testing beyond BRCA1/2 in breast/ovarian cancer Spanish families and clinical actionability of findings.
Bonache S, Esteban I, Moles-Fernández A, Tenés A, Duran-Lozano L, Montalban G, Bach V, Carrasco E, Gadea N, López-Fernández A, Torres-Esquius S, Mancuso F, Caratú G, Vivancos A, Tuset N, Balmaña J, Gutiérrez-Enríquez S, Diez O. Bonache S, et al. J Cancer Res Clin Oncol. 2018 Dec;144(12):2495-2513. doi: 10.1007/s00432-018-2763-9. Epub 2018 Oct 10. J Cancer Res Clin Oncol. 2018. PMID: 30306255
PURPOSE: Few and small studies have been reported about multigene testing usage by massively parallel sequencing in European cancer families. There is an open debate about what genes should be tested, and the actionability of some included genes is under research. M …
PURPOSE: Few and small studies have been reported about multigene testing usage by massively parallel sequencing in European cancer …
Familial pancreatic cancer: Concept, management and issues.
Matsubayashi H, Takaori K, Morizane C, Maguchi H, Mizuma M, Takahashi H, Wada K, Hosoi H, Yachida S, Suzuki M, Usui R, Furukawa T, Furuse J, Sato T, Ueno M, Kiyozumi Y, Hijioka S, Mizuno N, Terashima T, Mizumoto M, Kodama Y, Torishima M, Kawaguchi T, Ashida R, Kitano M, Hanada K, Furukawa M, Kawabe K, Majima Y, Shimosegawa T. Matsubayashi H, et al. World J Gastroenterol. 2017 Feb 14;23(6):935-948. doi: 10.3748/wjg.v23.i6.935. World J Gastroenterol. 2017. PMID: 28246467 Free PMC article. Review.
Familial pancreatic cancer (FPC) is broadly defined as two first-degree-relatives with pancreatic cancer (PC) and accounts for 4%-10% of PC. Several genetic syndromes, including Peutz-Jeghers syndrome, hereditary pancreatitis, hereditary breast- …
Familial pancreatic cancer (FPC) is broadly defined as two first-degree-relatives with pancreatic cancer (PC) and accou …
Genetic testing and familial implications in breast-ovarian cancer families.
Oosterwijk JC, de Vries J, Mourits MJ, de Bock GH. Oosterwijk JC, et al. Maturitas. 2014 Aug;78(4):252-7. doi: 10.1016/j.maturitas.2014.05.002. Epub 2014 May 9. Maturitas. 2014. PMID: 24894332 Review.
For the patient and family the main determinator still is whether a mutation is found or not. ...Surveillance for both index cases and relatives is based of the family history of cancer. Next generation genetic testing may help to elucidate genetic causes in …
For the patient and family the main determinator still is whether a mutation is found or not. ...Surveillance for both index cases an …
Familial pancreatic cancer.
Klein AP, Hruban RH, Brune KA, Petersen GM, Goggins M. Klein AP, et al. Cancer J. 2001 Jul-Aug;7(4):266-73. Cancer J. 2001. PMID: 11561603 Review.
Relatively little is known of its etiology, and the only well-established risk factor is cigarette smoking. Studies over the past 3 decades have shown that 4%-16% of patients with pancreatic cancer have a family history of the disease. A small fraction …
Relatively little is known of its etiology, and the only well-established risk factor is cigarette smoking. Studies over the past 3 decades …
Genetic susceptibility for breast cancer--risk assessment and counseling.
Ang P, Garber JE. Ang P, et al. Semin Oncol. 2001 Aug;28(4):419-33. doi: 10.1016/s0093-7754(01)90134-4. Semin Oncol. 2001. PMID: 11498834 Review.
Although most cancers do have a hereditary component, recognizing individuals who are at unusually high risk is important for planning their surveillance practices and considering options for risk management over a lifetime, and because of implications for their family …
Although most cancers do have a hereditary component, recognizing individuals who are at unusually high risk is important for plannin …
NCCN Guidelines Insights: Genetic/Familial High-Risk Assessment: Breast, Ovarian, and Pancreatic, Version 1.2020.
Daly MB, Pilarski R, Yurgelun MB, Berry MP, Buys SS, Dickson P, Domchek SM, Elkhanany A, Friedman S, Garber JE, Goggins M, Hutton ML, Khan S, Klein C, Kohlmann W, Kurian AW, Laronga C, Litton JK, Mak JS, Menendez CS, Merajver SD, Norquist BS, Offit K, Pal T, Pederson HJ, Reiser G, Shannon KM, Visvanathan K, Weitzel JN, Wick MJ, Wisinski KB, Dwyer MA, Darlow SD. Daly MB, et al. J Natl Compr Canc Netw. 2020 Apr;18(4):380-391. doi: 10.6004/jnccn.2020.0017. J Natl Compr Canc Netw. 2020. PMID: 32259785
The NCCN Guidelines for Genetic/Familial High-Risk Assessment: Breast, Ovarian, and Pancreatic provide recommendations for genetic testing and counseling for hereditary cancer syndromes, and risk management recommendations for patients who are diagnose …
The NCCN Guidelines for Genetic/Familial High-Risk Assessment: Breast, Ovarian, and Pancreatic provide recommendations …
Hereditary ovarian carcinoma.
Gallion HH, Smith SA. Gallion HH, et al. Semin Surg Oncol. 1994 Jul-Aug;10(4):249-54. doi: 10.1002/ssu.2980100404. Semin Surg Oncol. 1994. PMID: 8091066 Review.
More recently, genetic predisposition has been recognized as a strong risk factor for ovarian cancer. Three distinct hereditary syndromes have been identified: (1) breast-ovarian cancer syndrome, (2) hereditary nonpolyposis colon cancer, and (3) …
More recently, genetic predisposition has been recognized as a strong risk factor for ovarian cancer. Three distinct hereditary syndr …
High-risk epithelial ovarian cancer patients for hereditary ovarian cancer.
Chirasophon S, Manchana T, Teerapakpinyo C. Chirasophon S, et al. J Obstet Gynaecol Res. 2017 May;43(5):929-934. doi: 10.1111/jog.13287. Epub 2017 Feb 11. J Obstet Gynaecol Res. 2017. PMID: 28188963
High-risk patients were defined as patients who had: (i) significant family history of breast/ovarian/colorectal/endometrial cancers; (ii) synchronous breast/endometrial/colorectal cancer; or (iii) high-grade serous carcinoma. ...RESULTS: A tota …
High-risk patients were defined as patients who had: (i) significant family history of breast/ovarian/colorectal/endome …
164 results